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Study of the defense mechanism against infection of dental epithelial cell

Research Project

Project/Area Number 22592225
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionKagoshima University

Principal Investigator

ISHIHATA Kiyohide  鹿児島大学, 医学部・歯学部附属病院, 助教 (10437957)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Norifumi  鹿児島大学, 医学部・歯学部附属病院, 教授 (60217875)
KOMATSUZAWA Hitoshi  鹿児島大学, 医歯学総合研究科, 教授 (90253088)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords歯原性上皮細胞 / 抗菌ペプチド / 口腔外科 / 感染 / 細胞増殖 / E-cadherin / 感染防御メカニズム / 細菌感染 / 歯根嚢胞 / E-カドヘリン
Research Abstract

Radicular cyst is one of the periapical lesion, their formation is associated with the proliferation of epithelial cell rests of Malassez. However, little is currently known about the precise mechanisms of formation and enlargement of radicular cysts. The purpose of this study is to examine the levels of antimicrobial activities of periapical lesions, therefore, we evaluate the levels of antimicrobial peptide (AMP) and E-cadherin in periapical lesion and dental epithelial cell lines. These observations suggest that dental epithelial cells can secrete AMPs and consolidate epithelial intercellular junctions when stimulated by bacterial infection,and radicular cysts may play an important role in defense mechanisms.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2013 2012 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (4 results) Remarks (1 results)

  • [Journal Article] Expression of antimicrobial peptides and E-cadherin in periapical lesions2013

    • Author(s)
      Kiyohide Ishihata, Kenichi Kume, Hiroshi Hijioka, Toshiro Kibe, Shoko Tanaka, Hitoshi Komatsuzawa, Hidemitsu Harada, Norifumi Nakamura
    • Journal Title

      Oral Science International

      Volume: (in press)

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Analysis of expression of anti-microbial peptides and E-cadherin in radicular cysts and established dental epithelial cells2012

    • Author(s)
      石畑清秀
    • Organizer
      2nd International Joint Symposium on Oral and Dental Sciences
    • Place of Presentation
      インドネシア,ジョグジャカルタ
    • Year and Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯根嚢胞および歯原性上皮株における抗菌ペプチドならびに E-カドヘリンの発現解析2012

    • Author(s)
      石畑清秀,吉田裕真,久米健一,小松澤均,原田英光,宮脇昭彦,中村典史
    • Organizer
      第66回日本口腔科学会総会
    • Place of Presentation
      広島
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of expression of anti-microbial peptides and E-cadherin in radicular cysts and established dental epithelial cells2012

    • Author(s)
      Kiyohide Ishihata, Yuuma Yoshida, Kenichi Kume, Akihiko Miyawaki, Hitoshi Komatsuzawa, Hidemitsu Harada, Norifumi Nakamura
    • Organizer
      The second international joint symposium on oral and dental sciences
    • Place of Presentation
      Yogyakarta, Indonesia
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯根嚢胞および歯原性上皮細胞株における抗菌ペプチドならびにE-カドヘリン発現の解析2012

    • Author(s)
      石畑清秀,吉田裕真,久米健一,宮脇昭彦,小松澤均,原田英光,中村典史
    • Organizer
      第66回日本口腔科学会総会・学術大会
    • Place of Presentation
      広島
    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.hal.kagoshima-u.ac.jp/Omfs2/r_ishihata.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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