| Project/Area Number |
22592232
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
|
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| Research Institution | Tsurumi University (2011-2012)
Kanagawa Dental College (2010) |
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Principal Investigator |
ITO Yumi 鶴見大学, 歯学部, 講師 (00176372)
|
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| Co-Investigator(Kenkyū-buntansha) |
BHAWAL Ujjal 日本大学, 松戸歯学部, 助教 (50433339)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
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| Keywords | 炎症 / 低酸素関連遺伝子 / 時計遺伝子 / シグナル伝達 / ＤＥＣ / 時計遺 / 歯周病 / 糖尿病 / 時計遺伝子DEC / 炎症性サイトカイン |
|---|
| Research Abstract |
The aim of this study was to examine the expression of hypoxia responsive gene and clock gene DEC1 in gingival inflammation. We demonstrate that the pro-inflammatory cytokine interleukin-1β (IL-1β) up-regulated DEC1 and hypoxia-inducible factor-1α (HIF-1α) protein and elevated the HIF-1α-responsive gene vascular endothelial growth factor (VEGF) expression in human primary gingival cells. Furthermore, we clarify the signaling pathways (NF-kB, COX-2, and PI-3K-Akt) involved in the regulation of IL-1β-mediated DEC1 protein expression.
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