Signaling pathway analysis of hypoxia-related gene and clock geneDEC in gingival inflammation

• Project/Area Number: 22592232
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Tsurumi University (2011-2012); Kanagawa Dental College (2010)
• Principal Investigator: ITO Yumi 鶴見大学, 歯学部, 講師 (00176372)
• Co-Investigator(Kenkyū-buntansha): BHAWAL Ujjal 日本大学, 松戸歯学部, 助教 (50433339)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 炎症 / 低酸素関連遺伝子 / 時計遺伝子 / シグナル伝達 / ＤＥＣ / 時計遺 / 歯周病 / 糖尿病 / 時計遺伝子DEC / 炎症性サイトカイン

Research Abstract

The aim of this study was to examine the expression of hypoxia responsive gene and clock gene DEC1 in gingival inflammation. We demonstrate that the pro-inflammatory cytokine interleukin-1β (IL-1β) up-regulated DEC1 and hypoxia-inducible factor-1α (HIF-1α) protein and elevated the HIF-1α-responsive gene vascular endothelial growth factor (VEGF) expression in human primary gingival cells. Furthermore, we clarify the signaling pathways (NF-kB, COX-2, and PI-3K-Akt) involved in the regulation of IL-1β-mediated DEC1 protein expression.

Research Products

• [Journal Article] Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker incolorectal carcinoma (2013)
  • Author(s): Sasahira T, Ueda N, Kurihara M, Matsushima S, Ohmori H, Fujii K, Bhawal UK, Yamamoto K, Kirita T, Kuniyasu H
  • Journal Title: Human Pathology Volume: S0046-8177(12)
  • Peer Reviewed
• [Journal Article] Silk fibroin-based scaffoldsfor bone regeneration (2013)
  • Author(s): Kuboyama N, Kiba H, Arai K, Uchida R, Tanimoto Y, Bhawal UK, Abiko Y, Miyamoto S, Knight D, Asakura T, Nishiyama N
  • Journal Title: Journal of Biomedical Material Research B Appl Biomaterial Pages: 295-302
  • Peer Reviewed
• [Journal Article] Trks are novel oncogenes involved in the induction of neovascularization, tumor progression, and nodal metastasis in oral squamous cell carcinoma (2013)
  • Author(s): Sasahira T, Ueda N, Yamamoto K, Bhawal UK, Kurihara M, Kirita T, Kuniyasu H
  • Journal Title: Clinical Experimental Metastasis Volume: 30(2) Issue: 2 Pages: 165-176
  • DOI: 10.1007/s10585-012-9525-x
  • Peer Reviewed
• [Journal Article] Tropomyosin receptor kinases B and C are tumor progressive and metastatic marker in colorectal carcinoma (2013)
  • Author(s): Sasahira T, Ueda N, Kurihara M, Matsushima S, Ohmori H, Fujii K, Bhawal UK, Yamamoto K, Kirita T, Kuniyasu H
  • Journal Title: Human Pathology Volume: S0046-8177(12) Pages: 360-367
  • Peer Reviewed
• [Journal Article] Silk fibroin-based scaffolds for bone regeneration (2013)
  • Author(s): Kuboyama N, Kiba H, Arai K, Uchida R, Tanimoto Y, Bhawal UK, Abiko Y, Miyamoto S, Knight D, Asakura T, Nishiyama N.
  • Journal Title: J Biomed Mater Res B Appl Biomater Volume: Vol.101 Issue: 2 Pages: 295-302
  • DOI: 10.1002/jbm.b.32839
  • Peer Reviewed
• [Journal Article] IL-1β-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway (2012)
  • Author(s): Bhawal UK, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, Sasahira T, Hamada N, Kuniyasu H, Arakawa H, Kato Y, Abiko Y
  • Journal Title: Journal of Cellular Biochemistry Volume: 113(10) Pages: 3246-3253
  • Peer Reviewed
• [Journal Article] The BHLH transcription factor DEC1 plays an important role in the epithelial-mesenchymal transition of pancreatic cancer (2012)
  • Author(s): Wu, Y., Kawamoto, T., Noshiro, M., et al.(他10名)
  • Journal Title: Int J Oncol Volume: 41 Issue: 4 Pages: 1337-1346
  • DOI: 10.3892/ijo.2012.1559
  • Peer Reviewed
• [Journal Article] The basic helix-loop-helix transcription factor DEC2 inhibitsTGF-β-induced tumor progression in humanpancreatic cancer BxPC-3 cells (2012)
  • Author(s): Sato F, Kawamura H, Wu Y, Sato H, Jin D, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Seino H, Morohashi S, Kato Y, Kijima H
  • Journal Title: International Journal of Molecular Medicine Volume: 30(3) Pages: 495-501
  • Peer Reviewed
• [Journal Article] Identification by DNA microarray of genes involved in Candida albicans-treated gingival epithelial cells (2012)
  • Author(s): Ikuta T, Bhawal UK, Tsushima K, Aoki A, Kuboyama N, Abiko Y
  • Journal Title: Journal of Oral Pathology & Medicine Volume: 41(10) Pages: 769-778
  • Peer Reviewed
• [Journal Article] Downregulation of miR-126 induces angiogenesis and lymphangiogenesis (2012)
  • Author(s): Sasahira T, Kurihara M, Bhawal UK, Ueda N, Shimomoto T, Yamamoto K, Kirita T, Kuniyasu H
  • Journal Title: activation of VEGF-A in oral cancer Volume: 107(4) Pages: 700-706
  • Peer Reviewed
• [Journal Article] Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver (2012)
  • Author(s): Sato F, Sato H, Jin D, Bhawal UK, Wu Y, NoshiroM, Kawamoto T, Fujimoto K, SeinoH, Morohashi S, Kato Y, Kijima H
  • Journal Title: Biochemical Biophysics ResearchCommunication Volume: 419(2) Pages: 441-446
  • Peer Reviewed
• [Journal Article] Involvement of HMGB1 and RAGE in IL-1β-induced gingivalinflammation (2012)
  • Author(s): Ito Y, Bhawal UK, Sasahira T, Toyama T, Sato T, Matsuda D, Nishikiori H, Kobayashi M, Sugiyama M, Hamada N, Arakawa H, Kuniyasu H
  • Journal Title: Archives of Oral Biology Volume: 57(1) Pages: 73-80
  • Peer Reviewed
• [Journal Article] The basic helix-loop-helix transcription factor DEC2 inhibits TGF-beta-induced tumor progression in human pancreatic cancer BxPC-3 cells (2012)
  • Author(s): Sato, F., Kawamura, H., Kawamoto, T., Noshiro, M.,(他10名)
  • Journal Title: Int J Mol Med Volume: 30 Issue: 3 Pages: 495-501
  • DOI: 10.3892/ijmm.2012.1037
  • Peer Reviewed
• [Journal Article] Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer (2012)
  • Author(s): Sasahira T, Kurihara M, Bhawal UK, Ueda N, Shimomoto T, Yamamoto K, Kirita T, Kuniyasu H
  • Journal Title: British Journal of Cancer Volume: 107(4) Issue: 4 Pages: 700-706
  • DOI: 10.1038/bjc.2012.330
  • Peer Reviewed
• [Journal Article] Smad3 and Snail show circadian expression in human gingival fibroblasts, human mesenchymal stem cell, and in mouse liver (2012)
  • Author(s): Sato F, Sato H, Jin D, Bhawal UK, Wu Y, NoshiroM, Kawamoto T, Fujimoto K, Seino H, Morohashi S, Kato Y, Kijima H
  • Journal Title: Biochemical Biophysics Research Communication Volume: 419(2) Pages: 441-446
  • Peer Reviewed
• [Journal Article] Involvement of HMGB1 and RAGE in IL-1β-induced gingival inflammation (2012)
  • Author(s): Ito Y, Bhawal UK, Sasahira T, Toyama T, Sato T, Matsuda D, Nishikiori H, Kobayashi M, Sugiyama M, Hamada N, Arakawa H, Kuniyasu H
  • Journal Title: Archives of Oral Biology Volume: 57(1) Pages: 73-80
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Bhawal UK, Sato F, Arakawa Y, Fujimoto K, Kawamoto T, Tanimoto K, Ito Y, Sasahira T, Sakurai T, Kobayashi M, Kashima I, Kijima H, Kuniyasu H, Abiko Y, Kato Y, Sato S
  • Journal Title: Journal of Pathology Volume: 224(3) Pages: 420-429
  • Peer Reviewed
• [Journal Article] PERIOD1 (PER1) has anti- apoptotic effects, and PER3 has pro- apoptotic effects during cisplatin (CDDP) treatment in humangingival cancer CA9- 22 cells (2011)
  • Author(s): Sato F, Wu Y, Bhawal UK, Liu Y, ImaizumiT,Morohashi S, Kato Y, Kijima H
  • Journal Title: EuropeanJournal of Cancer Volume: 47(11) Pages: 1747-1758
  • Peer Reviewed
• [Journal Article] Basic helix- loop- helix transcription factors DEC1 and DEC2 regulate the paclitaxel- induced apoptotic pathway of MCF- 7 human breast cancer cells (2011)
  • Author(s): Wu Y, Sato F, Bhawal UK, Kawamoto T, FujimotoK, Noshiro M, Morohashi S, KatoY, Kijima H
  • Journal Title: International Journal of MolecularMedicine Volume: 27(4) Pages: 491-495
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of β- TCP implanted in dog mandible (2011)
  • Author(s): Zhao J, Watanabe T, Bhawal UK, Kubota E,Abiko Y
  • Journal Title: Bone Volume: 48(4) Pages: 864-877
  • Peer Reviewed
• [Journal Article] PERIOD1 (PER1) has anti-apoptotic effects, and PER3 has pro-apoptotic effects during cisplatin (CDDP) treatment in human gingival cancer CA9-22 cells (2011)
  • Author(s): Sato F, Wu Y, Bhawal UK, Liu Y, Imaizumi T, Morohashi S, Kato Y, Kijima H
  • Journal Title: European Journal of Cancer Volume: 47(11) Pages: 1747-1758
  • Peer Reviewed
• [Journal Article] Basic helix-loop-helix transcription factors DEC1 and DEC2 regulate the paclitaxel-induced apoptotic pathway of MCF-7 human breast cancer cells (2011)
  • Author(s): Wu Y, Sato F, Bhawal UK, Kawamoto T, Fujimoto K, Noshiro M, Morohashi S, Kato Y, Kijima H
  • Journal Title: International Journal of Molecular Medicine Volume: 27(4) Pages: 491-495
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of β-TCP implanted in dog mandible (2011)
  • Author(s): Zhao J, Watanabe T, Bhawal UK, Kubota E, Abiko Y
  • Journal Title: Bone Volume: 48(4) Pages: 864-877
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor(VEGF) expression is negatively regulated by basic-helix loop helix(BHLH) transcription factor DEC2. (2010)
  • Author(s): Hiroshi Kijima
  • Journal Title: Hirosaki Med.J. Volume: 61
• [Journal Article] Trks are novel oncogenes involved in the induction of neovascularization, tumor progression, and nodal metastasis in oralsquamous cell carcinoma
  • Author(s): Sasahira T, Ueda N, Yamamoto K, Bhawal UK, Kurihara M, Kirita T, Kuniyasu H
  • Journal Title: ClinicalExperimental Metastasis Volume: 30(2)
  • Peer Reviewed
• [Presentation] Yoshimitsu Abiko (2013)
  • Author(s): Ujjal K. Bhawal
  • Organizer: Transcription factor DEC1 andEpithelial-Mesenchymal Transition, 2013.03
  • Place of Presentation: Seattle, Washington, USA
• [Presentation] Transcription factor DEC1 and Epithelial-Mesenchymal Transition (2013)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: IADR/AADR/CADR General Session & Exhibition
  • Place of Presentation: Washington State Convention Center, Seattle, Washington, USA
  • Invited
• [Presentation] Molecular mechanism of transcription factors DEC1 and DEC2 in cancer (2012)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: 日本分子生物学会
  • Place of Presentation: 福岡
• [Presentation] Yoshimitsu Abiko,Molecular mechanism of transcription factors DEC1 and DEC2 in tumor (2012)
  • Author(s): Ujjal K. Bhawal
  • Organizer: IADR.
  • Place of Presentation: Seoul, Korea
• [Presentation] IL-1β-mediated up-regulation of DEC1 in gingiva cells via Akt pathway (2012)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: アメリカ歯周病学会共催日本歯周病学会
  • Place of Presentation: LA,USA
• [Presentation] Smad3 shows circadian expression in human gingival fibroblasts and human mesenchymal stem cells (2012)
  • Author(s): Ujjal K. Bhawal, Yumi Ito, TomonoriSasahira, Hiroki Kuniyasu, Yoshimitsu Abiko
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Expression of TANGO in oral cancer (2012)
  • Author(s): Tomonori Sasahira, Ujjal K. Bhawal,Miyako Kurihara, Nobuhiro Ueda, Kazuhiko Yamamoto, Tadaaki Kirita, Hiroki Kuniyasu
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Micromolar level NaF promotes epithelial cell growth and reduces Porphyromonas gingivalis-induced alveolar bone loss (2012)
  • Author(s): UK. Bhawal, Dawei He, N Hamada, N Kuboyama, Y Abiko, H Arakawa
  • Organizer: FDI Annual World Dental Congress
  • Place of Presentation: Hong Kong, China
• [Presentation] Identification by DNA microarray of genes involved in micromolar level NaF-treated epithelial cells (2012)
  • Author(s): UK. Bhawal, Dawei He, Y Arakawa, H Arakawa, Y Abiko
  • Organizer: 日本口腔衛生学会総会
  • Place of Presentation: 横須賀
• [Presentation] 口腔扁平上皮癌における CXCL14 のエピジェネティックス機構を介した遺伝子発現制御 (2012)
  • Author(s): バワール ウジャール、 伊藤由美 、安孫 子宜光
  • Organizer: 日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 口腔扁平上皮癌における CXCL14 のエピジェネティックス機構を介した遺伝子発現制御 (2012)
  • Author(s): バワール ウジャール、伊藤由美、安孫子宜光
  • Organizer: 日本病理学会総会
  • Place of Presentation: 京王プラザホテル、東京
  • Invited
• [Presentation] Micromolar Fluoride Reduces Alveolar Bone Loss in Experimental Rat Periodontitis (2012)
  • Author(s): Dawei He, Ujjal K. Bhawal, Yuki Arakawa, Yoshimitsu Abiko, Hirohisa Arakawa
  • Organizer: 日本口腔衛生学会総会
  • Place of Presentation: 神奈川歯科大学、横須賀、神奈川
  • Invited
• [Presentation] Identification by DNA microarray of genes involved in micromolar level NaF-treated epithelial cells (2012)
  • Author(s): Ujjal K. Bhawal, Dawei He, Yuki Arakawa, Hirohisa Arakawa, Yoshimitsu Abiko
  • Organizer: 日本口腔衛生学会総会
  • Place of Presentation: 神奈川歯科大学、横須賀、神奈川
  • Invited
• [Presentation] Functional analysis of transcription factors DEC1 and DEC2 in tumor (2012)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: 国際歯科研究学会議(IADR)
  • Place of Presentation: イグアスフォールズ、ブラジル
  • Invited
• [Presentation] Micromolar level NaF promotes epithelial cell growth and reduces Porphyromonas gingivalis-induced alveolar bone loss (2012)
  • Author(s): Ujjal K. Bhawal, Dawei He, Nobushiro Hamada, Noboru Kuboyama, Yoshimitsu Abiko, Hirohisa Arakawa
  • Organizer: FDI Annual World Dental Congress
  • Place of Presentation: Hong Kong Convention and Exhibition Centre, Hong Kong, China
  • Invited
• [Presentation] Expression of TANGO in oral cancer (2012)
  • Author(s): Tomonori Sasahira, Ujjal K. Bhawal, Miyako Kurihara, Nobuhiro Ueda, Kazuhiko Yamamoto, Tadaaki Kirita, Hiroki Kuniyasu
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: ホテルロイトン札幌、北海道
  • Invited
• [Presentation] Smad3 shows circadian expression in human gingival fibroblasts and human mesenchymal stem cells (2012)
  • Author(s): Ujjal K. Bhawal, Yumi Ito, Tomonori Sasahira, Hiroki Kuniyasu, Yoshimitsu Abiko
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: ホテルロイトン札幌、北海道
  • Invited
• [Presentation] IL-1β-mediated up-regulation of DEC1 in gingiva cells via Akt pathway (2012)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: アメリカ歯周病学会共催日本歯周病学会
  • Place of Presentation: Los Angeles Convention Center, Los Angeles, CA, USA
  • Invited
• [Presentation] Molecular mechanism of transcription factors DEC1 and DEC2 in tumor (2012)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: IADR (Korean Division)
  • Place of Presentation: Sejong University, Seoul, Korea
  • Invited
• [Presentation] Molecular mechanism of transcription factors DEC1 and DEC2 in cancer (2012)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: 日本分子生物学会
  • Place of Presentation: 福岡国際会議場、福岡
  • Invited
• [Presentation] Functional analysis of BHLH transcription factor DEC1 and DEC2 in tumor (2011)
  • Author(s): Sato F, Wu Y, Bhawal UK, Kato Y, Kijima H
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)(招待講演)
  • Year and Date: 2011-12-14
• [Presentation] ヒト口腔扁平上皮癌におけるPERIOD(PER1)とPER3の発現 (2011)
  • Author(s): Ujjal K.Bhawal, Katsumasa Tsushima, Tonami Ikuta, Yoshimitsu Abiko
  • Organizer: 第59回国際歯科研究学会日本部会(JADR)総会・学術
  • Place of Presentation: 広島国際会議場(広島県)(招待講演)
  • Year and Date: 2011-10-09
• [Presentation] Basic-helix-loop-helix (bHLH) transcription factor DEC1 regulates CyclinD1 expression through E-box element (2011)
  • Author(s): Bhawal UK, Sato F, Sasahira T, Ito Y, Kuniyasu H, Kijima H, Abiko Y
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-10-05
• [Presentation] Functional analysis of miR-126 in oral cancer (2011)
  • Author(s): Sasahira T, Kurihara M, Bhawal UK, Yamamoto K, Kirita T, Kuniyasu H
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] Anti-angiotensin and hypoglycemic treatments suppress liver metastasis of colon cancer cells (2011)
  • Author(s): Fujii K, Luo Y, Bhawal UK, Yoshikawa M, Maruyama H, Chihara Y, Kuniyasu H
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] ヒト口腔扁平上皮癌におけるPERIOD(PERI)とPER3の発現 (2011)
  • Author(s): Bhawal UK、伊藤由美、安孫子宜光
  • Organizer: 第53回歯科基礎医学会
  • Place of Presentation: 長良川国際会議場(岐阜県)(招待講演)
  • Year and Date: 2011-10-02
• [Presentation] 炎症におけるDEC1とDEC2の役割 (2011)
  • Author(s): Bhawal UK、伊藤由美、安孫子宜光
  • Organizer: 第53回歯科基礎医学会
  • Place of Presentation: 長良川国際会議場(岐阜県)(招待講演)
  • Year and Date: 2011-10-02
• [Presentation] Micromolar Fluoride Reduces Alveolar Bone Loss in Experimental Rat Periodontitis (2011)
  • Author(s): Dawei He, UK. Bhawal, Y Arakawa, Y Abiko, H Arakawa
  • Organizer: 日本口腔衛生学会総会
  • Place of Presentation: 横須賀
• [Presentation] Functional analysis of BHLH transcription factor DEC1 and DEC2 in tumor (2011)
  • Author(s): Sato F, Wu Y, Bhawal UK, Kato Y, Kijima H
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 横浜
• [Presentation] Abiko Y,Basic-helix-loop-helix (bHLH) transcription factor DEC1 regulates CyclinD1 expression through E-box element (2011)
  • Author(s): Bhawal UK, Sato F, Sasahira T, Ito Y, Kuniyasu H, Kijima H
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Functional analysis of miR-126 in oral cancer (2011)
  • Author(s): Sasahira T, Kurihara M, Bhawal UK, Yamamoto K, Kirita T, Kuniyasu H
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] Anti-angiotensin and hypoglycemic treatments suppress liver metastasis of colon cancer cells (2011)
  • Author(s): Fujii K, Luo Y, Bhawal UK, Yoshikawa M, Maruyama H, Chihara Y, Kuniyasu H
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] ヒト口腔扁平上皮癌におけるPERIOD (PER1)とPER3の発現 (2011)
  • Author(s): Bhawal UK、伊藤由美 、安孫子宜光
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 岐阜
• [Presentation] 炎症におけるDEC1とDEC2の役割 (2011)
  • Author(s): Bhawal UK、 伊藤由美 、安孫子宜光
  • Organizer: 歯科基 礎医学会
  • Place of Presentation: 岐阜
• [Presentation] ヒト口腔扁平上皮癌におけるPERIOD (PER1) と PER3の発現 (2011)
  • Author(s): Ujjal K. Bhawal, Katsumasa Tsushima, Tonami Ikuta, Yoshimitsu Abiko
  • Organizer: 国際歯科研究学会日本部会 総会(IADR)
  • Place of Presentation: 広島
• [Presentation] Molecular mechanism of hypoxia inducible gene DEC in oral inflammation and cancer (2010)
  • Author(s): Ujjal K Bhawal
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: リーガロイヤルホテル(大阪)
  • Year and Date: 2010-09-23
• [Presentation] Molecular mechanism of hypoxia inducible gene DEC in oral inflammation and cancer (2010)
  • Author(s): Ujjal K Bhawal
  • Organizer: 第52回日本歯科基礎医学会学術大会・総会
  • Place of Presentation: タワーホール船掘(千葉)
  • Year and Date: 2010-09-21
• [Presentation] 口腔扁平上皮におけるCXCL14のエピジェネティックス機構を介した遺伝子発現制御 (2010)
  • Author(s): Ujjal K Bhawal
  • Organizer: 第52回日本歯科基礎医学会学術大会・総会
  • Place of Presentation: タワーホール船掘(千葉)
  • Year and Date: 2010-09-21
• [Presentation] Functional analysis of transcription factors DEC1 and DEC2 in tumor (2010)
  • Author(s): Ujjal K. Bhawal, Yoshimitsu Abiko
  • Organizer: 国際歯科研究 学会議(IADR)
  • Place of Presentation: イグアスフォー ルズ、ブラジル