| Project/Area Number |
22592241
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Kagoshima University |
|---|
Principal Investigator |
HIJIOKA Hiroshi 鹿児島大学, 大学院・医歯学総合研究科, 助教 (70305150)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SETOGUCHI Takao 鹿児島大学, 医歯学総合研究科, その他 (40423727)
MIYAWAKI Akihiko 産業医科大学, 附属病院, 講師 (40200216)
ISHIDA Takayuki 鹿児島大学, 医歯学総合研究科, 助教 (20404501)
KOMIYA Setsuro 鹿児島大学, 医歯学総合研究科, 教授 (30178371)
NAKAMURA Norifumi 鹿児島大学, 医歯学総合研究科, 教授 (60217875)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | Notchシグナル / 口腔扁平上皮癌 / EMT / 低酸素 / 口腔癌 / 上皮間葉移行(EMT) / 低酸素環境(Hypoxia) |
|---|
| Research Abstract |
The aim of this study is to investigate the significance of Notch signaling in oral squamous cell carcinoma(OSCC) and to explore the potential of new molecular target therapy for OSCC. We demonstrated that Notch signaling is activated in OSCC and inhibition of Notch pathway prevents OSCC growth. Further we showed hypoxia induced EMT in OSCC via activation of Notch signaling. These findings suggest that inhibition of Notch pathway may be a useful approach for the treatment of patients with OSCC.
|
