• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug

Research Project

Project/Area Number 22592243
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionYokohama City University

Principal Investigator

MITSUDO Kenji  横浜市立大学, 医学部, 准教授 (70303641)

Co-Investigator(Kenkyū-buntansha) TOHNAI Iwai  横浜市立大学, 医学研究科, 教授 (50172127)
KUROTANI Reiko  横浜市立大学, 医学研究科, 特任助教 (00453043)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords口腔癌 / 新規磁性抗癌剤 / 家兎 VX2 癌 / 温熱療法 / Drug Delivery System / 家兎VX2癌 / 新規磁性抗がん剤 / 温熱化学療法 / 化学療法 / 家兎VX2舌癌 / 家兎VX2癌細胞 / Drug Delivery System (DDS) / ハイパーサーミア
Research Abstract

A new magnetic anticancer drug (=New drug) was developed giving an anti-tumor effect by fragmenting DNA and controlling cell proliferation, depending on its density. The New drug is characterized by being a magnetic substance, which accumulates locally through impression of a magnetic field using a permanent magnet. As a result, it could be used as a drug delivery system. In addition, it was clarified that the New drug generates heat because of the high frequency magnetic field impression; thus, it is expected to be effective for intra-tissue hyperthermia.We performed a comparative MTT assay assessing the antitumor effects of the New drug against cisplatin(CDDP), an anticancer drug mainly used for oral cancer. We also created a tongue tumor model into which the VX2 cell line was transplanted, and performed an animal experiment using the New drug. This result suggests that EI236 become a new drug for the treatment of oral cancer.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 9 results) Presentation (22 results) (of which Invited: 1 results)

  • [Journal Article] Thermochemoradiotherapy for Oral Cancer with N2, 3 Cervical Lymph Node Metastases using Retrograde Superselective Intra-Arterial Infusion2012

    • Author(s)
      Mitsudo K, Koizumi T, Iida M, Mitsunaga S, Tohnai I
    • Journal Title

      Themal Med

      Volume: 28(2) Pages: 23-28

    • NAID

      130004504391

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases.2012

    • Author(s)
      Mitsudo K, Koizumi T, Iida M, Iwai T, Oguri S, Yamamoto N, Itoh Y, Kioi M, Hirota M, Tohnai I.
    • Journal Title

      Inl J Radiat Oncol Biol Phys

      Volume: 83(5)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermochemoradiation therapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases.2012

    • Author(s)
      Mitsudo K
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 83

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermochemoradiotherapy for Oral Cancer with N2,3 Cervical Lymph Node Metastases using Retrograde Superselective Intra-arterial Infusion.2012

    • Author(s)
      Mitsudo K
    • Journal Title

      Thermal Med

      Volume: 28(2) Pages: 23-28

    • NAID

      10030780941

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 lymphnode metastases2012

    • Author(s)
      Mitsudo K, 他
    • Journal Title

      International Journal of Radiation Oncology, Biology, Physics

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermochemoradiotherapy using superselective intra-arterial infusion forN3 cervical lymph node metastases of tongue cancer2012

    • Author(s)
      Nishiguchi H, Mitsudo K, 他
    • Journal Title

      Journal of Cancer Research and Therapeutics

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of oral cancer treatment using a new magnetic anticancer drug2011

    • Author(s)
      Sato I, Mitsudo K., 他
    • Journal Title

      Global COE Program : Annual Report 2010

      Pages: 155-156

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Organ preservation with daily concurrent chemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery for T3 and T4 head and neck cancer2011

    • Author(s)
      Mitsudo K., et al.
    • Journal Title

      Inl J Radiat Oncol Biol Phys

      Volume: 79 Pages: 1428-1435

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 進行口腔癌に対する浅側頭動脈よりの超選択的動注法を用いた連日同時放射線化学療法-腫瘍栄養動脈による頸部転移リンパ節への病理組織効果-2010

    • Author(s)
      光藤健司, 他
    • Journal Title

      日本口腔科学会雑誌

      Volume: 59 Pages: 1-8

    • NAID

      10027092924

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 進行口腔癌に対する逆行性超選択的動注化学療法,放射線同時併用療法後の救済手術2010

    • Author(s)
      光藤健司, 他
    • Journal Title

      日本口腔腫瘍学会雑誌

      Volume: 22 Pages: 102-106

    • NAID

      10029089500

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of oral cancer treatment using a new magnetic anticancer drug2012

    • Author(s)
      Sato I, Mitsudo K, Iida M, Nakashima H, Eguchi H, Koizumi T, Kioi M, Ishikawa Y, Tohnai I
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      Hyatt Kyoto
    • Year and Date
      2012-08-31
    • Related Report
      2012 Final Research Report
  • [Presentation] Clinical evaluation of thermochemoradiotherapy for advancedhead and neck cancer.2012

    • Author(s)
      Iida M, Mitsudo K, Koizumi T, Iwai T, Oguri S, Kioi M, Hirota M, Nakashima H, Tohnai I
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      Hyatt Kyoto
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for advanced oral cancer with cervical lymph node metastases.2012

    • Author(s)
      Koizumi T, Mitsudo K, Iida M, Iwai T, Oguri S, Kioi M, Hirota M, Tohnai I
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      Hyatt Kyoto
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Hyperthermia sensitizes resistant human oral cancer cells to IL-13 cytotoxin2012

    • Author(s)
      Nakashima H, Kioi M, Ookubo M, Sugiura K, Sato I, Iida M, Mitsudo K, Husain SR, Puri RK, Tohnai I
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      Hyatt Kyoto
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases2012

    • Author(s)
      Mitsudo K, Koizumi T, Iida M, Iwai T, Oguri S, Yamamoto N, Kioi M, Hirota M, Tohnai I.
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      Hyatt Kyoto
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Hyperthermia using magnetic nanoparticle combined with intratumoral dendritic cells enhance antitumor effect.2012

    • Author(s)
      Yamamoto N, Matsumoto K, Furue H, Hagiwara S, Nishikawa M, Hibi H, Shigetomi T, Mitsudo K, Tohnai I, Kobayashi T, Ueda M.
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      Hyatt Kyoto
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] Organ preservation with daily concurrent chemoradiotherapy using retrograde superselective intra-arterial infusion for stage III, IV oral cancer: analysis of therapeutic results in 112 Cases2012

    • Author(s)
      Mitsudo K, Koizumi T, Iwai T, Nakashima H, Oguri S, Kioi M, Hirota M, Tohnai I
    • Organizer
      American Society of Clinical Oncology (ASCO) Annual Meeting
    • Place of Presentation
      Chicago (USA)
    • Year and Date
      2012-06-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規磁性体EI236を用いた抗腫瘍効果の検討2012

    • Author(s)
      佐藤格, 光藤健司, 他
    • Organizer
      Global COE学術会議
    • Place of Presentation
      はまぎんホール、神奈川
    • Year and Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of oral cancer treatment using a new magnetic anticancer drug2012

    • Author(s)
      Sato I, Mitsudo K., 他
    • Organizer
      国際学術フォーラム
    • Place of Presentation
      情文ホール、神奈川
    • Year and Date
      2012-02-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Organ preservation with daily concurrent chemoradiotherapy using retrograde superselective intra-arterial infusion for advanced oral cancer.2012

    • Author(s)
      Mitsudo K
    • Organizer
      62nd Der Deutschen Gesellschaft fur Mund- Kiefer- und Gesichtschirurgie
    • Place of Presentation
      Freiburg, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for oral cancer with N3 cervical lymph node metastases.2012

    • Author(s)
      Mitsudo K.
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      ハイアットリージェンシー京都(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Hyperthermia sensitizes resistant human oral cancer cells to IL-13 cytotoxin.2012

    • Author(s)
      Nakashima H.
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      ハイアットリージェンシー京都(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Clinical evaluation of thermochemoradiotherapy for advanced head and neck cancer.2012

    • Author(s)
      Iida M.
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      ハイアットリージェンシー京都(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via superficial temporal and occipital arteries for advanced oral cancer with cervical lymph node metastases.2012

    • Author(s)
      Koizumi M.
    • Organizer
      11th International Congress of Hyperthermic Oncology
    • Place of Presentation
      ハイアットリージェンシー京都(京都府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新規磁性体EI236を用いた新しいがん治療の開発2011

    • Author(s)
      佐藤格, 光藤健司, 他
    • Organizer
      第28回日本ハイパーサーミア学会
    • Place of Presentation
      ウインク愛知、愛知県
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery and an occipital artery for N3 cervical lymph node metastases of oral cancer.2011

    • Author(s)
      Mitsudo K, Yamamoto N, Koizumi T, Iwai T, Nishiguchi H, Hirota M, Tohnai I
    • Organizer
      3rdWorld Congress of International Academy of Oral Oncology
    • Place of Presentation
      Singapore (Singapore)
    • Year and Date
      2011-07-15
    • Related Report
      2012 Final Research Report
  • [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery and an occipital artery for N3 cervical lymphnode metastases of oral cancer2011

    • Author(s)
      Mitsudo K., 他
    • Organizer
      3^<rd> World Congress of International Academy of Oral Oncology
    • Place of Presentation
      Grand Copthorne Waterfront Hotel, Singapore
    • Year and Date
      2011-07-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 浅側頭動脈,後頭動脈よりの超選択的動注法-カテーテル留置から管理まで-2010

    • Author(s)
      光藤健司
    • Organizer
      第55回日本口腔外科学会総会、ミニレクチャー
    • Place of Presentation
      千葉県・幕張メッセ
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 進行口腔癌に対する浅側頭動脈よりの超選択的動注化学放射線療法-腫瘍栄養動脈による頸部転移リンパ節への病理組織効果-2010

    • Author(s)
      光藤健司, 他
    • Organizer
      第64回日本口腔科学会
    • Place of Presentation
      北海道・札幌プリンスホテル
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 口腔癌に対する超選択的動注化学療法-大腿動脈経由と逆行性との比較-2010

    • Author(s)
      光藤健司
    • Organizer
      第64回日本口腔科学会、イブニングセミナー
    • Place of Presentation
      北海道・札幌プリンスホテル
    • Year and Date
      2010-06-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] 進行口腔癌に対する逆行性超選択的動注化学放射線療法-過去3年間の治療成績-2010

    • Author(s)
      光藤健司, 他
    • Organizer
      第34回日本頭頸部癌学会総会
    • Place of Presentation
      東京都・京王プラザホテル
    • Year and Date
      2010-06-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] Thermochemoradiotherapy using superselective intra-arterial infusion via a superficial temporal artery and an occipital artery for N3 cervical lymphnode metastases of oral cancer2010

    • Author(s)
      Mitsudo Kenji, et.al.
    • Organizer
      5^<th> Asian Congress of Hyperthermic Oncology, Symposium
    • Place of Presentation
      福岡県・九州大学医学部百年講堂
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi