| Project/Area Number |
22592243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641)
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| Co-Investigator(Kenkyū-buntansha) |
TOHNAI Iwai 横浜市立大学, 医学研究科, 教授 (50172127)
KUROTANI Reiko 横浜市立大学, 医学研究科, 特任助教 (00453043)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔癌 / 新規磁性抗癌剤 / 家兎 VX2 癌 / 温熱療法 / Drug Delivery System / 家兎VX2癌 / 新規磁性抗がん剤 / 温熱化学療法 / 化学療法 / 家兎VX2舌癌 / 家兎VX2癌細胞 / Drug Delivery System (DDS) / ハイパーサーミア |
|---|
| Research Abstract |
A new magnetic anticancer drug (=New drug) was developed giving an anti-tumor effect by fragmenting DNA and controlling cell proliferation, depending on its density. The New drug is characterized by being a magnetic substance, which accumulates locally through impression of a magnetic field using a permanent magnet. As a result, it could be used as a drug delivery system. In addition, it was clarified that the New drug generates heat because of the high frequency magnetic field impression; thus, it is expected to be effective for intra-tissue hyperthermia.We performed a comparative MTT assay assessing the antitumor effects of the New drug against cisplatin(CDDP), an anticancer drug mainly used for oral cancer. We also created a tongue tumor model into which the VX2 cell line was transplanted, and performed an animal experiment using the New drug. This result suggests that EI236 become a new drug for the treatment of oral cancer.
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