Thermochemotherapy with controlled drug delivery using a novel magnetic anti-cancer drug
| Project/Area Number |
22592243
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
MITSUDO Kenji 横浜市立大学, 医学部, 准教授 (70303641)
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| Co-Investigator(Kenkyū-buntansha) |
TOHNAI Iwai 横浜市立大学, 医学研究科, 教授 (50172127)
KUROTANI Reiko 横浜市立大学, 医学研究科, 特任助教 (00453043)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 口腔癌 / 新規磁性抗癌剤 / 家兎 VX2 癌 / 温熱療法 / Drug Delivery System / 家兎VX2癌 / 新規磁性抗がん剤 / 温熱化学療法 / 化学療法 / 家兎VX2舌癌 / 家兎VX2癌細胞 / Drug Delivery System (DDS) / ハイパーサーミア |
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| Research Abstract |
A new magnetic anticancer drug (=New drug) was developed giving an anti-tumor effect by fragmenting DNA and controlling cell proliferation, depending on its density. The New drug is characterized by being a magnetic substance, which accumulates locally through impression of a magnetic field using a permanent magnet. As a result, it could be used as a drug delivery system. In addition, it was clarified that the New drug generates heat because of the high frequency magnetic field impression; thus, it is expected to be effective for intra-tissue hyperthermia.We performed a comparative MTT assay assessing the antitumor effects of the New drug against cisplatin(CDDP), an anticancer drug mainly used for oral cancer. We also created a tongue tumor model into which the VX2 cell line was transplanted, and performed an animal experiment using the New drug. This result suggests that EI236 become a new drug for the treatment of oral cancer.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] Hyperthermia using magnetic nanoparticle combined with intratumoral dendritic cells enhance antitumor effect.2012
Author(s)
Yamamoto N, Matsumoto K, Furue H, Hagiwara S, Nishikawa M, Hibi H, Shigetomi T, Mitsudo K, Tohnai I, Kobayashi T, Ueda M.
Organizer
11th International Congress of Hyperthermic Oncology
Place of Presentation
Hyatt Kyoto
Year and Date
2012-08-30
Related Report
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