functional analysis of novel two specific oral cancer marker detected from saliva

• Project/Area Number: 22592245
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Showa University
• Principal Investigator: MATSUURA Mitsuhiro 昭和大学, 歯学部, 助教 (00297037)
• Co-Investigator(Kenkyū-buntansha): SHINTANI Satoru 昭和大学, 歯学部, 教授 (80294429)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 唾液 / 腫瘍マーカー

Research Abstract

Salivary proteomic analysis was performed to obtein a reliable screening test for early diagnosis of oral squamous cell carcinoma and that the cystatin SN and salivary acidic proline-rich phosphoprotein 3/4 might be a promising tumor biomarker for oral squamous cell carcinoma.

Research Products

• [Journal Article] A potential anticancer activity of extracts derived from the roots of Scutellaria baicalensis on humanoral squamous cell carcinoma cells (2013)
  • Author(s): Sato D, Yazawa K, Kondo S, Mukudai Y, Li C,Kamatani T, Katsuta H, Yoshihama Y,Shirota T,Shintani S
  • Journal Title: Molecular and Clinical Oncology Volume: 1 Issue: 1 Pages: 105-111
  • DOI: 10.3892/mco.2012.14
  • Peer Reviewed
• [Journal Article] The root bark of Paeonia moutan is a potential anticancer agent in human oral squamous cell carcinoma cells (2012)
  • Author(s): Li C, Yazawa K, Kondo S, Mukudai Y, Sato D,Kurihara Y, Kamatani T, Shintani S
  • Journal Title: Anticancer research Volume: 32 Pages: 2625-2630
  • Peer Reviewed
• [Journal Article] Increased telomerase activity and hTERT expression in human salivary gland carcinomas (2011)
  • Author(s): Shigeishi, et al
  • Journal Title: Oncology letters Volume: 2 Pages: 845-850
  • Peer Reviewed
• [Journal Article] STAT3 as a target of molecular targeting therapy for oral cancer : cell-based screening using inhibitor screenig kits (2011)
  • Author(s): Nagumo, et al
  • Journal Title: Asian journal of oral and maxillofacial surgery Volume: 23 Pages: 167-171
  • Peer Reviewed
• [Journal Article] Evaluation of the anticancer activities of Na+/K+-ATPase inhibitor, sanguinarine in human oral squamous cell carcinoma cell lines (2011)
  • Author(s): Tsukamoto, et al
  • Journal Title: Anticancer research Volume: 31 Pages: 2841-2846
  • Peer Reviewed
• [Journal Article] Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral leukaemia insertion (Fli)-1 is a predictionmarker candidate for radiotherapy resistant oral squamous cell carcinoma (2010)
  • Author(s): Shintani S, Hamakawa K, Nakashiro K, Shirota T, Hatori M, Tanaka,M, Kuroshita Y, Kurokawa Y
  • Journal Title: International Journal of Oral Maxillofacial Surgery Volume: 39(11) Pages: 1115-1119
  • Peer Reviewed
• [Journal Article] Identification of a truncated cystatin SA-1 as a saliva biomarker for oral squamous cell carcinoma using the SELDI ProteinChip platform (2010)
  • Author(s): Shintani S, Hamakawa H, Ueyama Y, Hatori M, Toyoshima T
  • Journal Title: International Journal of Oral Maxillofacial Surgery Volume: 39(1) Pages: 439-443
  • Peer Reviewed
• [Journal Article] Genome-wide cDNA microarray screening to reveal gene-expression profiles correlated to chemosensitivity of oral squamous cell carcinoma cell lines (2010)
  • Author(s): Shintani S, Nakashiro K, Hamakawa H, Shirota T, Hatori M, Kawamoto Y, Sasaki A
  • Journal Title: Asian Journal of Oral Maxillofacial Surgery Volume: 22 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Identification of a truncated cystatin SA-1 as a saliva biomarker for oral squamous cell carcinoma using the SELDI ProteinChip platform (2010)
  • Author(s): Shintani, et al.
  • Journal Title: Internatinal Journal Oral Maxillofacial Surgery Volume: 39 Pages: 68-74
  • Peer Reviewed
• [Journal Article] Friend leukaemia insertion (Fli)-1 is a prediction marker candidate for radiotherapy resistant oral leukaemia insertion(Fli)-1 is a prediction markercandidate for radiotherapy resistant oral squamous cell carcinoma (2010)
  • Author(s): Shintani, et al.
  • Journal Title: Internatinal Journal Oral Maxillofacial Surgery Volume: 22 Pages: 7-11
  • Peer Reviewed
• [Journal Article] Genome-wide cDNA microarray screening to reveal gene-expression profiles correlated to chemosensitivity of oral squamous cell carcinoma cell lines (2010)
  • Author(s): Shintani, et al.
  • Journal Title: Asian Journal Oral Maxillofacial Surgery Volume: 22 Pages: 7-11
  • Peer Reviewed
• [Presentation] Epigenomic profiling of oral cancer (2012)
  • Author(s): Yoshiba S, Nagae G, Kaneda A, Tsuji S, Matsusaka K, Yagi, K, Isagawa T, Tachikawa T, Shintani S, Aburatani H
  • Organizer: 2012AACR
  • Place of Presentation: chicago, Illinois, USA
  • Year and Date: 2012-04-05
• [Presentation] Telomerase-Specific Replication-Selective Virotherapy combined with radiation therapy for oral squamous cell carcinoma cells (2012)
  • Author(s): Kurihara Y, Sato D, Shirota T, Kondo S, Kataoka M, Urata Y, Fujiwara T, Shintani S
  • Organizer: 2012AACR
  • Place of Presentation: chicago, Illinois, USA
  • Year and Date: 2012-04-05
• [Presentation] Telomerase-Specific Replication-Selective oncolytic viruses for adenoid cystic. carcinoma cell lines (2012)
  • Author(s): Sato D, Kurihara Y, Kondo S, ShirotaT,Urata Y, Fujiwara T, Shintani S
  • Organizer: 2012AACR
  • Place of Presentation: chicago, Illinois, USA
  • Year and Date: 2012-04-05
• [Presentation] IL-1βによる口腔扁平上皮癌のスクリーニング検査法の開発 (2011)
  • Author(s): 鎌谷, ら
  • Organizer: 第56回日本口腔外科学会総会・学術大会
  • Place of Presentation: 大阪市
  • Year and Date: 2011-10-21
• [Presentation] Anti-tumor Activity of Dehydroxymethylepoxyquinomicin against Human Oral Squamous Cell Carcinoma Cell Lines in vitro and in vivo (2010)
  • Author(s): Yasuda, et al.
  • Organizer: 9th Asian Congress on Oral and Maxillofacial Surgery
  • Place of Presentation: Kuala Lumpur, Malaysia
• [Presentation] Saliva tumor markers for the identification of oral cancer European (2008)
  • Author(s): Shintani S, Hatori,M Toyoshima T, Kurihara Y, Kurokawa Y, Nakahira H, Ito T, Shirota T
  • Organizer: Association for Cranio-Maxillofacial Surgery
  • Place of Presentation: Bologna Italy
• [Remarks]
  • URL: http://www.omfs-showa.jp/