A study on interaction of cancer stem cells and microenvironment (niche)and stromal fibroblasts (CAF)
| Project/Area Number |
22592248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Kazuma 兵庫医科大学, 医学部, 講師 (50309473)
URADE Masahiro 兵庫医科大学, 医学部, 教授 (70104883)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 臨床腫瘍学 / 癌幹細胞 / 口腔癌 / 微小環境 / 間質線維芽細胞 |
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| Research Abstract |
We divided SP cells with cell line of SCC-25,OSC-19,OSC-20.We confirmed SP cells with one of three extraction specimens which obtained its consent from the patients. The CD44-positive surgery specimen had much 4D of the YK classification.We were able to confirm that there was the specimen which couldn't divide SP cells even if CD44 was positive, and only CD44 did not become the marker of stem cells. The speed of the cell proliferation is slow, and there is not passage with all cell line though it cultures discrete SP cells in a serum-free medium.The cells did not perish for approximately around one month, but it developed that a growth rate wasslow than person normal cells.
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Report
(4 results)
Research Products
(20 results)
