| Project/Area Number |
22592250
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | National Defense Medical College |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SATOU Yasunori 防衛医科大学校, 病院, 教授 (10095375)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
TANZAWA Hideki 千葉大学, 大学院医学研究院臨床分子生物学教室, 教授 (50236775)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
|---|
| Keywords | 細胞接着因子 / 癌転移抑制法 / 癌浸潤抑制法 / KCNJ2 / β-catenin / βcatenin / KCNJ / Lin7C |
|---|
| Research Abstract |
The aim of this study was to develop a new method of inhibiting the invasion and metastasis of oral squamous cell carcinoma (OSCC) through the activating KCNJ2-Lin7C-CASK-βcatenin pathway. As the result of suppressed expression of KCNJ2 which located upstream of βcatenin, βcatenin expression levels were increased. In addition, we identified some molecules of upstream of KCNJ2 by the Ingenuity Pathway Analysis, and then focused amiodarone which is the drug of ventricular tachycardia. After treatment with this drug, expression levels of Lin7C, CASK and βcatenin were significantly up-regulated. We suggested that the specific KCNJ2 inhibitor, amiodarone, closely related to KCNJ2-Lin7C-CASK-βcatenin pathway, and therefore might be a therapeutic agent for cancer invasion and metastasis.
|
