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Development of the method of treatment for neuropathic pain -Basic study of the effect of iontophoresis-

Research Project

Project/Area Number 22592253
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SHIMADA Masahiko  東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (40170948)

Co-Investigator(Kenkyū-buntansha) YAMAZAKI Yoko  東京医科歯科大学, 歯学部附属病院, 助教 (90366609)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsACイオントフォレーシス / DCイオントフォレーシス / 神経因性疼痛 / CCI / Fos / 脳・神経 / イオントフォレーシス
Research Abstract

This study aimed to compare the effect of alternating current iontophoresis (AC IOP) with direct current iontophoresis (DC IOP). As a result of behavior and immunohistological experiment, DC IOP have a fast onset time and a short effect time, while AC IOP have a slow onset time and a long effect time. According to the result of the blood concentration of lidocaine, we confirmed that those effects were not caused by systemic administration of lidocaine. Additionally, those electrical powers we applied did not lead to extravasation of Evans Blue in the skins under the electrodes.
Thus, these findings of this study suggest that AC IOP is useful for patients suffering from chronic pain because of its long effect time.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (7 results)

All 2013 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (6 results)

  • [Journal Article] The effect of alternating current iontophoresis on rats with the chronic constriction injury to the infraorbital nerve2012

    • Author(s)
      Yamazaki Y, Umino M, Fukayama H, Shimada M
    • Journal Title

      Int J Den

      Volume: 2012 Pages: 1-7

    • DOI

      10.1155/2012/405292

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ラットの顔面皮膚における直流および交流電流を用いたイオントフォレーシスの電極下の皮膚状態の検討2013

    • Author(s)
      山崎陽子, 新美知子, 安藤祐子, 冨澤大佑, 井村紘子, 細田明利, 川島正人, 嶋田昌彦
    • Organizer
      第41回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-04
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 直流および交流電流を用いたイオントフォレーシスのラットの三叉神経核におけるFos用タンパク陽性細胞発現数の比較2012

    • Author(s)
      山崎陽子, 新美知子, 安藤祐子, 冨澤大佑, 井村紘子, 細田明利, 川島正人, 嶋田昌彦
    • Organizer
      第40回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-10-05
    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Presentation] ラットの行動実験による直流および交流電流を用いたイオントフォレーシスの効果の比較2011

    • Author(s)
      山崎陽子, 新美知子, 安藤祐子, 冨澤大佑, 井村紘子, 細田明利, 川島正人, 嶋田昌彦
    • Organizer
      第39回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2011-10-08
    • Related Report
      2013 Final Research Report
  • [Presentation] ラットの行動実験による直流および交流電流を用いたイオントフォレーシスの効果の比較2011

    • Author(s)
      山崎陽子
    • Organizer
      第39回歯科麻酔学会総会・学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 直流および交流電流を用いたイオントフォレーシスによるラットの逃避行動への効果の比較2011

    • Author(s)
      山﨑陽子,嶋田昌彦
    • Organizer
      第40回日本慢性疼痛学会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 直流および交流電流を用いたイオントフォレーシスによるラットの逃避行動への効果の比較2011

    • Author(s)
      山崎陽子
    • Organizer
      第40回日本慢性疼痛学会
    • Place of Presentation
      アルカディア市ヶ谷(東京都)
    • Year and Date
      2011-02-25
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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