| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We studied the effects of goshajinkigan (GJG) on mechanical hypersensitivity in ovariectomized rats with infraorbital nerve injury using the von Frey test. The results showed the potential development of gradual analgesic action with chronic administration of GJG. In addition, a difference was apparent between the ovariectomy and sham operation groups, and thus ovariectomy itself may reduce the analgesic effect induced by GJG. Examination of the effects of estradiol (Es) replacement in the same model indicated that Es acted to aggravate acute inflammation while mitigating chronic conditions such as neuropathic pain.
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