Sensitization of trigeminal nervous system by infraorbital nerve injury exacerbates the pathophysiology of migraine
| Project/Area Number |
22592257
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUDO Chiho 大阪大学, 歯学部附属病院, 助教 (20533110)
NIWA Hitoshi 大阪大学, 大学院・歯学研究科, 教授 (30218250)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 歯科麻酔学 / 片頭痛 / 三叉神経系 / 慢性口腔顔面痛 / 眼窩下神経結紮 / カプサイシン / pERK / 口腔顔面痛 / Cortical Spreading Depression / 慢性痛 / 脳・神経 |
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| Research Abstract |
We established the chronic constriction injury of the infraorbital nerve (ION-CCI) rat model as a chronic orofacial pain model (neuropathic pain model) by ION loose ligation. At 3 weeks after ION-CCI, the dura was stimulated by 10mM capsaicin, which was the one of the migraine models, followed by checking the expression of the phosphorylated extracellular signal-regulated kinase (pERK) at the trigeminal spinal subnucleus caudalis by immunohistochemical staining method. It showed that the pERK-immunoreactive neurons statistically increased between ovex and 1440 μm caudally in ION-CCI + capisaisin stimulating group compared to capsaicin stimulating group. Taken together, the sensitization of 2nd branch of trigeminal nerve by ION-CCI affected the activation of 1stbranch of trigeminal nerve by capsaicin, suggesting that chronic orofacial pain may exacerbates the pathophysiology of migraine.
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Report
(4 results)
Research Products
(2 results)
