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Sensitization of trigeminal nervous system by infraorbital nerve injury exacerbates the pathophysiology of migraine

Research Project

Project/Area Number 22592257
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka University

Principal Investigator

MORIMOTO Yoshinari  大阪大学, 歯学部附属病院, 講師 (00264870)

Co-Investigator(Kenkyū-buntansha) KUDO Chiho  大阪大学, 歯学部附属病院, 助教 (20533110)
NIWA Hitoshi  大阪大学, 大学院・歯学研究科, 教授 (30218250)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords歯科麻酔学 / 片頭痛 / 三叉神経系 / 慢性口腔顔面痛 / 眼窩下神経結紮 / カプサイシン / pERK / 口腔顔面痛 / Cortical Spreading Depression / 慢性痛 / 脳・神経
Research Abstract

We established the chronic constriction injury of the infraorbital nerve (ION-CCI) rat model as a chronic orofacial pain model (neuropathic pain model) by ION loose ligation. At 3 weeks after ION-CCI, the dura was stimulated by 10mM capsaicin, which was the one of the migraine models, followed by checking the expression of the phosphorylated extracellular signal-regulated kinase (pERK) at the trigeminal spinal subnucleus caudalis by immunohistochemical staining method. It showed that the pERK-immunoreactive neurons statistically increased between ovex and 1440 μm caudally in ION-CCI + capisaisin stimulating group compared to capsaicin stimulating group. Taken together, the sensitization of 2nd branch of trigeminal nerve by ION-CCI affected the activation of 1stbranch of trigeminal nerve by capsaicin, suggesting that chronic orofacial pain may exacerbates the pathophysiology of migraine.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2013

All Presentation (2 results)

  • [Presentation] 慢性口腔顔面痛モデルを用いた、片頭痛発症の誘発因子としての三叉神経系感作の解明2013

    • Author(s)
      遠山 緑、森本佳成、工藤千穂、丹羽 均
    • Organizer
      第41回日本歯科麻酔学会総会・学術大会
    • Place of Presentation
      新横浜国際ホテル、神奈川県横浜市
    • Year and Date
      2013-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 慢性口腔顔面痛モデルを用いた、片頭痛発症の誘発因子としての三叉神経系感作の解明2013

    • Author(s)
      遠山 緑、森本佳成、工藤千穂、丹羽 均、
    • Organizer
      第41回日本歯科麻酔学会総会・学術大会
    • Place of Presentation
      神奈川県横浜市
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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