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The changes of pain threshold affected by external environment

Research Project

Project/Area Number 22592268
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

TOMIDA Mihoko  松本歯科大学, 歯学部, 准教授 (00366329)

Co-Investigator(Kenkyū-buntansha) ONOZUKA Minoru  神奈川歯科大学, 歯学部, 教授 (90084780)
NAKAMURA Takami  松本歯科大学, 歯学部, 助手 (40549367)
ANDO Hiroshi  松本歯科大学, 歯学部, 講師 (30312094)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords歯科麻酔学 / 疼痛閾値 / fMRI / 音楽 / 除痛 / 疼痛 / 環境 / 帯状回
Research Abstract

In the present study, we examined the effects of additional sensory stimulation in attenuating perception of pain in intact humans using VAS (visual analog scale), Pain Vision and fMRI (functional magnetic resonance imaging). When the subjects listened to music, the reduction in the VAS value and the increasing of sense perception or pain threshold are observed. Moreover, BOLD signal in the cingulated cortex during listening to music was attenuated on the fMRI. These results suggested that the music may affect pain perception and threshold.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (43 results)

All 2013 2012 2011 2010 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (25 results) Book (1 results)

  • [Journal Article] The Endogenous Opioids Related with Antinociceptive Effects Induvced by Electrical Stimulation into the Amygdala.2013

    • Author(s)
      Takami Nakamura
    • Journal Title

      The Open Dentistry Journal

      Volume: 7 Issue: 1 Pages: 1-9

    • DOI

      10.2174/1874210601307010027

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression and correlation analysis of β-adrenoceptors, VEGF, MMP-9 and caspase-3 in different phases of infantile hemangioma.2013

    • Author(s)
      Weili Yuan
    • Journal Title

      J Hard Tissue Biology

      Volume: 22 Pages: 51-58

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Newlydesigned gustatory test based on the number of chewing strokes required for recognition of the taste.2012

    • Author(s)
      Kasahara T, Yamashita S, Niimura H, Hotta H, Tomida M, Asanuma N.
    • Journal Title

      J Prothodont Res

      Volume: 56 Pages: 210-215

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Newly designed gustatory test based on the number of chewing strokes required for recognition of the taste2012

    • Author(s)
      Takao Kasahara
    • Journal Title

      Journal of Prosthodontic Research

      Volume: 56 Issue: 3 Pages: 210-215

    • DOI

      10.1016/j.jpor.2011.09.004

    • NAID

      130004546644

    • ISSN
      1883-1958, 1883-9207
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The factors related with the number of chewing strokes for recognizing taste.2011

    • Author(s)
      Tomida M, Numao H, Yamashita S, Kasahara T, Nakamura T, Ando H, Takamata T, Asanuma N.
    • Journal Title

      J Oral Biosci

      Volume: 53 Pages: 338-347

    • NAID

      10030175623

    • URL

      http://mol.medicalonline.jp/library/journal/download?GoodsID=ct4biosc/2011/005304/007&name=0338-0347e&UserID=1200001557-09&base=jamas_pdf

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological examination of newly-developedadhesive silicone denture relining material.2011

    • Author(s)
      Tomida M, Nakano K, Sato M, Matsuura S, Kawakami T.
    • Journal Title

      Eur J Med Res

      Volume: 16 Pages: 328-330

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352005/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kawakami T. Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use.2011

    • Author(s)
      Tomida M, Nakano K, Matsuura S
    • Journal Title

      EurJ Med Res

      Volume: 16 Pages: 249-252

    • URL

      http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3353399/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative examination of subcutaneous tissue reaction to high molecular materials in medical use2011

    • Author(s)
      Mihoko Tomida, et.al.
    • Journal Title

      Eur J Med Res

      Volume: 16 Pages: 249-252

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histopathological examination of newly-developed adhesive silicone denture relining material2011

    • Author(s)
      Mihoko Tomida, et.al.
    • Journal Title

      Eur J Med Res

      Volume: 16 Pages: 328-330

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The factors related with the number of chewing strokes for recognizing taste2011

    • Author(s)
      Mihoko Tomida, et.al.
    • Journal Title

      J.Oral Biosci.

      Volume: 53 Pages: 338-347

    • NAID

      10030175623

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Co-expression of BMP-2 and -7 in the Tumoral Epithelium of CEOT with Selective BMP-7 Expression in Amyloid Materials2011

    • Author(s)
      Chong Huat Siar, et.al.
    • Journal Title

      J Hard Tissue Biology

      Volume: 20 Pages: 125-132

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch signaling and ghost cell fate in the calcifying cystic odontogenic tumor2011

    • Author(s)
      Chong Huat Siar, et.al.
    • Journal Title

      Eur J Med Res

      Volume: 16 Pages: 501-506

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Deuterium Oxide on Streptococcus mutans and Pseudomonas aeruginosa.2010

    • Author(s)
      Hirai K, Tomida M, Kikuchi U, Ueda O, Ando H, Asanuma N.
    • Journal Title

      Bull Tokyo Dent Coll

      Volume: 51 Pages: 175-183

    • NAID

      130004471698

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Squamous odontogenic tumor of the mandible : a case report demonstrating immunoexpression of notch1, 3, 4, jagged1 and delta12010

    • Author(s)
      C.H.Siar, et.al.
    • Journal Title

      Eur J Med Res

      Volume: 15 Pages: 180-184

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Deuterium Oxide on Streptococcus mutans and Pseudomonas aeruginosa2010

    • Author(s)
      Kaname Hirai, et.al.
    • Journal Title

      Bulletin of Tokyo Dental College

      Volume: 51 Pages: 175-183

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possibility of odontoblasts activity up-regulation due to orthodontic mechanical stress in mice2010

    • Author(s)
      Keisuke Nakano, et.al.
    • Journal Title

      Hard Tissue Biology

      Volume: 19 Pages: 13-16

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯科医療費に関する意識調査-第一報:外来患者, 歯科医師, 歯学部学生との比較-2010

    • Author(s)
      中村貴美, 他
    • Journal Title

      松本歯学

      Volume: 36 Pages: 199-208

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 疼痛に及ぼす音楽の影響.2012

    • Author(s)
      富田美 穂子、中村貴 美 、武井賢郎、 安藤 宏、浅沼直和
    • Organizer
      第22回日本歯科医学総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] 疼痛抑制系における 扁桃体の役割2012

    • Author(s)
      中村貴 美、富 田美穂 子、安 藤宏 、金銅英二、 鷹股哲也、浅沼直和
    • Organizer
      第22回日本歯科医学総会
    • Place of Presentation
      大阪
    • Related Report
      2012 Final Research Report
  • [Presentation] Transplanted bone marrow-derived cell migration into periodontal tissues induced by orthodontic mechanical stress.2012

    • Author(s)
      Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nagatsuka H, Kawakami T.
    • Organizer
      24th International Congress of the Transplantation Society
    • Place of Presentation
      Berlin, Germany)
    • Related Report
      2012 Final Research Report
  • [Presentation] Kawakami T. Migration of the transplanted bone marrow-derived cells into periodontal ligaments due to orthodontic mechanical stress2012

    • Author(s)
      Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nakamura T, Asanuma N, Nagatsuka H
    • Organizer
      The physiology society
    • Place of Presentation
      Edinburgh, Scotland)
    • Related Report
      2012 Final Research Report
  • [Presentation] Electrical stimulation applied to the amygdala facilitates secretion of endogenous opioids in theperiaqueductal gray.2012

    • Author(s)
      Nakamura T, Tomida M, Ando H Takamata T, Kondo E, Asanuma N.
    • Organizer
      The physiology society
    • Place of Presentation
      Edinburgh, Scotland)
    • Related Report
      2012 Final Research Report
  • [Presentation] 侵害刺激に対する内因性オピオイドの分泌2011

    • Author(s)
      中村貴美、富田美穂子、安藤宏、金銅英二、浅沼直和.
    • Organizer
      第53回歯科基礎医学会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-09-30
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Promoting effect of mechanical stress to transplanted bone marrow-derived cell migration into periodontal tissues.2011

    • Author(s)
      Tomida M, Tsujigiwa H, Nakano K, Muraoka R, Nagattsuka H, Kawakami T.
    • Organizer
      The5th Meeting of Asian society of Oral and maxillofacial Pathology
    • Place of Presentation
      Hakata
    • Related Report
      2012 Final Research Report
  • [Presentation] 疼痛感受性に及ぼす口腔機能および音楽の影響2011

    • Author(s)
      富田美穂子、山下秀一郎、大塚剛郎、小野塚実、中村貴美、安藤宏、浅沼直和
    • Organizer
      第88回日本生理学会大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Final Research Report
  • [Presentation] Promoting effect of mechanical stress to transplanted bone marrow-derived cell migration into periodontal tissus2011

    • Author(s)
      Mihoko Tomida, et.al.
    • Organizer
      The 5th Meeting of Asian society of Oral and maxillofacial Pathology
    • Place of Presentation
      Hakata
    • Related Report
      2011 Annual Research Report
  • [Presentation] Use of gamma knife radiosurgery for trigerminal neuralgia2010

    • Author(s)
      Mihoko Tomida, et.al.
    • Organizer
      10^<th> European Association of oral medicine
    • Place of Presentation
      London (England)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effect of Oral function on pain perception2010

    • Author(s)
      Takami Nakamura, et.al.
    • Organizer
      10^<th> European Association of oral medicine
    • Place of Presentation
      London (England)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohistochemical expression of notch signaling in calcifying cystic odontogenic tumor2010

    • Author(s)
      Toshiyuki Kawakami, et.al.
    • Organizer
      10^<th> European Association of oral medicine
    • Place of Presentation
      London (England)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Expression of Runx2 in dental root pulp cells due to orthodontic Mechanical stress2010

    • Author(s)
      Keisuke Nakano, et.al.
    • Organizer
      10^<th> European Association of oral medicine
    • Place of Presentation
      London (England)
    • Year and Date
      2010-09-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウシガエル舌におけるニューロンの免疫組織化学的特徴2010

    • Author(s)
      田所治, 他
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      タワーホール船堀(千葉)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 顎変形症患者における手術後の食品摂取の傾向2010

    • Author(s)
      竹内由里, 他
    • Organizer
      第57回日本栄養改善学会学術大会
    • Place of Presentation
      女子栄養大学(坂戸)
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 顎変形症手術患者における退院後の栄養摂取に関する問題点の抽出2010

    • Author(s)
      小城明子, 他
    • Organizer
      第16回 日本摂食・嚥下リハビリテーション学会学術大会
    • Place of Presentation
      朱鷲メッセ(新潟)
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自己学習を促す学力強化システムの確立2010

    • Author(s)
      富田美穂子, 他
    • Organizer
      教育改革ICT戦略大会
    • Place of Presentation
      アルカディア市ヶ谷(東京)
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Newly-Designed gustatory test based on progress of mastication2010

    • Author(s)
      Takao Kasahara, et.al.
    • Organizer
      IADR 88^<th> General session & Exhibition
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Use of gamma knife radiosurgery for trigerminal neuralgia.2010

    • Author(s)
      Tomida M, Hayashi M, Kouyama N, Katayama Y, Kawkami Y, Nakamura T, Asanuma N.
    • Organizer
      10th European Association of oral medicine
    • Place of Presentation
      London, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Effect of Oral function on pain perception. 10th European2010

    • Author(s)
      Nakamura T, Tomida M, Yamashita S,Otsuka T, Onozuka M, Ando H, Asanuma N.
    • Organizer
      Association of oral medicine
    • Place of Presentation
      London, UK
    • Related Report
      2012 Final Research Report
  • [Presentation] Migration of the transplanted bone marrow-derived cells into periodontal ligaments due to orthodontic mechanical stress

    • Author(s)
      Mihoko Tomida
    • Organizer
      The physiology society 2012
    • Place of Presentation
      Edinburgh (Scotland)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Electrical stimulation applied to the amygdala facilitates secretion of endogenous opiods in the periaqueductal gray

    • Author(s)
      Taqakami Nakamura
    • Organizer
      The physiology society 2012
    • Place of Presentation
      Edinburgh (Scotland)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Transplanted bone marrow-derived cell migration into periodontal tissues induced by orthodontic mechanical stress

    • Author(s)
      Mihoko Tomida
    • Organizer
      24th International Congress of The Transplantation Society
    • Place of Presentation
      Berlin (Germany)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 疼痛に及ぼす音楽の影響

    • Author(s)
      富田美穂子
    • Organizer
      第22回日本歯科医学総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 疼痛抑制系における扁桃体の役割

    • Author(s)
      中村貴美
    • Organizer
      第22回日本歯科医学総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2012 Annual Research Report
  • [Book] Pathological Bases of Root Canal Restoration Using calcium Hydroxide Paste2012

    • Author(s)
      Mihoko Tomida
    • Publisher
      IDP Publishers, Inc, Editor Toshiyuki Kawakami
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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