Localization of Perlecan and Heparanase in the Epithelial

• Project/Area Number: 22592269
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Aichi Gakuin University
• Principal Investigator: SUGAHARA Toshio 愛知学院大学, 歯学部, 客員教授 (10116048)
• Co-Investigator(Kenkyū-buntansha): HIRATA Azumi 大阪医科大学, 医学部, 助教 (40263587) ; MINAMI Katsuhiro 愛知学院大学, 歯学部, 講師 (70346162) ; FUJIWARA Kumiko 愛知学院大学, 歯学部, 講師 (60404737) ; IMURA Hideto 愛知学院大学, 歯学部, 非常勤講師 (10513187)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 口蓋裂 / 発生メカニズム / パールカン / 上皮索基底膜 / 口蓋突起 / 基底膜 / ヘパラナーゼ

Research Abstract

We examined the immunolocalization pattern of heparan sulfate (HS) and heparanase (HPSE) in order to clarify their roles in murine palatal boneformation in palatogenesis.Heparanase might contribute to the formation of hard palate bycleaving of heparan sulfate chains of HSPG in bone matrix.

Research Products

• [Journal Article] Effect of 2,3,7,8-tetrachlorodibenzo-p- dioxin suggests abnormal palate development after palatal fusion (2010)
  • Author(s): Imura H, Yamada T, Mishima K, Fujiwara K, Kawaki H, Hirata A, Sogawa N, Ueno T, Sugahara T
  • Journal Title: Congenit Anom Volume: 50(2) Pages: 77-84
  • NAID: 10029577625
  • Peer Reviewed
• [Journal Article] Localization of the HOXChomeobox gene family during palateformation in mice (2010)
  • Author(s): Hirata, A., Tsuji, T., Imura, H., Yamada,T., Ueno, T., Mishima, K., Natsume, N.,Sugahara, T., Koga, Y., Takano, K. andNakamura, H.
  • Journal Title: Selected papersfrom the XX Congress of the European Association of Cranio-Maxillo-FacialSurgery Pages: 415-420
  • Peer Reviewed
• [Journal Article] Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin suggests abnormal palate development after palatal fusion (2010)
  • Author(s): Imura H
  • Journal Title: Congenital Anomalies Volume: 50(2) Pages: 77-84
  • Peer Reviewed
• [Journal Article] Localization of the HOXC homeobox gene family during palate formation in mice (2010)
  • Author(s): Hirata.A
  • Journal Title: EUROPEAN ASSOCIATION FOR CRANIO-MAXILLO-FACIAL SURGER 2010. International Proceedings Pages: 415-420
  • Peer Reviewed
• [Presentation] Total TMJ replacement for obstructive sleep apnea syndrome associated with TMJ destruction due to rheumatoid arthritis (2012)
  • Author(s): Toshio SUGAHARA, Katsuhiro MINAMI, Katsuaki MISHIMA, Yoshihide MORI,Tomohiro YAMADA, Hideto IMURA, Azumi HIRATA, Nagato NATSUME
  • Organizer: XXI Congress of the European Assosiation of Cranio-Maxillo-Facial Surgery (Dubrovnik) Croatia
• [Presentation] HEPARANASELOCALIZATION DURING PALATOGENESIS INMICE (2012)
  • Author(s): Azumi Hirata, Hideto Imura, TakaakiUeno, Katsuhiro Minami, NagatoNatsume, Toshio Sugahara
  • Organizer: XXI Congress of the EuropeanAssosiation of Cranio-Maxillo-FacialSurgery(Dubrovnik)Croatia
• [Presentation] Total TMJ replacement for obstructive sleep apnea syndrome associated with TMJ destruction due to rheumatoid arthritis (2012)
  • Author(s): Toshio Sugahara
  • Organizer: XXI Congress of the European Assosiation of Cranio-Maxillo-Facial Surgery
  • Place of Presentation: (Dubrovnik)Croatia
  • Invited
• [Presentation] HEPARANASE LOCALIZATION DURING PALATOGENESIS IN MICE (2012)
  • Author(s): Azumi Hirata
  • Organizer: XXI Congress of the European Assosiation of Cranio-Maxillo-Facial Surgery
  • Place of Presentation: (Dubrovnik)Croatia
• [Presentation] Homeobox familyHOX遺伝子は口蓋形成に関与する (2011)
  • Author(s): 平田あずみ、井村英人、南克浩、夏目長門、菅原利夫
  • Organizer: 第56回日本口腔外科学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-10-21
• [Presentation] Homeobox family HOX遺伝子は口蓋形成に関与する (2011)
  • Author(s): 平田あずみ、井村英人、南克浩、夏目長門、菅原利夫
  • Organizer: 第56回日本口腔外科学会総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2011-10-21
• [Presentation] Localization of HeparanSulfate and Heparanase during PalatalBone Formation in Palatogenesis in Mice (2010)
  • Author(s): Tosho Sugahara
  • Organizer: EUROPEAN ASSOCIATION FOR C
  • Place of Presentation: RANIO-MAXILLO-FACIAL SURGER2010 Congress Bruges
• [Presentation] Localization of Heparan Sulfate and Heparanase during Palatal Bone Formation in Palatogenesis in Mice (2010)
  • Author(s): Tosho Sugahara
  • Organizer: EUROPEAN ASSOCIATION FOR CRANIO-MAXILLO-FACIAL SURGER 2010 Congress
  • Place of Presentation: Bruges
• [Book] 今日の治療指針 (2012)
  • Author(s): 菅原利夫, 他
  • Total Pages: 2064
  • Publisher: 医学書院
• [Book] 口腔外科専門医マニュアル (2011)
  • Author(s): 菅原利夫
  • Publisher: 医歯薬出版
• [Book] 口腔外科専門医マニュアル (2011)
  • Author(s): 菅原利夫, 他
  • Total Pages: 362
  • Publisher: 医歯薬出版株式会社