Elucidation of cerebral protection of lidocaine with transient corticalischemia/reperfusion model
| Project/Area Number |
22592271
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAMAE Masami 大阪歯科大学, 歯学部, 講師 (20298821)
MATSUYAMA Tomohiro 兵庫医科大学, 医学部, 教授 (10219529)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳,神経 / 脳神経疾患 / 神経科学 / 再生医学 / 脳・神経 / 歯学 |
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| Research Abstract |
Reduction of infarct size was confirmed in comparison with the control group 5 days after 30 min middle cerebral artery occlusion (MCAO) and reperfusion by administering lidocaine before MCAO. Expression of Caspase3 in infarct area was observed slightly in both lidocaine and control group by immunohistochemical staining, but there was not difference between the two groups. Nestin-positive neural stem cells were expressed around microvasculature in the infarct area and penumbra region. It was suggested that nestin-positive neural stem cells were often observed as a cause of the infarct zone reduced by pharmacological preconditioning of lidocaine, enhancement of nerve regeneration wit that is different from the reactive glial cells.
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Report
(4 results)
Research Products
(47 results)
