• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of cerebral protection of lidocaine with transient corticalischemia/reperfusion model

Research Project

Project/Area Number 22592271
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionOsaka Dental University

Principal Investigator

MOMOTA Yoshihiro  大阪歯科大学, 歯学部, 講師 (60247880)

Co-Investigator(Renkei-kenkyūsha) MIYAMAE Masami  大阪歯科大学, 歯学部, 講師 (20298821)
MATSUYAMA Tomohiro  兵庫医科大学, 医学部, 教授 (10219529)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords脳,神経 / 脳神経疾患 / 神経科学 / 再生医学 / 脳・神経 / 歯学
Research Abstract

Reduction of infarct size was confirmed in comparison with the control group 5 days after 30 min middle cerebral artery occlusion (MCAO) and reperfusion by administering lidocaine before MCAO. Expression of Caspase3 in infarct area was observed slightly in both lidocaine and control group by immunohistochemical staining, but there was not difference between the two groups. Nestin-positive neural stem cells were expressed around microvasculature in the infarct area and penumbra region. It was suggested that nestin-positive neural stem cells were often observed as a cause of the infarct zone reduced by pharmacological preconditioning of lidocaine, enhancement of nerve regeneration wit that is different from the reactive glial cells.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (47 results)

All 2013 2012 2011 2010

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (36 results) Book (2 results)

  • [Journal Article] An highly reproducible model of cerebralischemia/reperfusion with extended survival in CB-17 mice2013

    • Author(s)
      Kasahara Y, Ihara M, Nakagomi T, Momota Y, Sterm D, Matsuyama T, Taguchi A
    • Journal Title

      Neurosci Res

      Volume: 76 Issue: 3 Pages: 163-168

    • DOI

      10.1016/j.neures.2013.04.001

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dental management under general anesthesia in an intellectually disabled adult patient with phenylketonuria.2013

    • Author(s)
      Matsushita Y, Momota Y, Kotani J
    • Journal Title

      J Dent Sci

      Volume: 8 Issue: 1 Pages: 96-97

    • DOI

      10.1016/j.jds.2012.12.003

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dedifferentiated fat cells differentiate into osteoblasts in titanium fiber mesh2013

    • Author(s)
      Kishimoto N, Momota Y, Hashimoto Y, Ando K, Omasa T, Kotani J
    • Journal Title

      Cytotechnology

      Volume: 65 Issue: 1 Pages: 15-22

    • DOI

      10.1007/s10616-012-9456-z

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sevoflurane confers additive cardioprotection to ethanol preconditioning associated with enhanced phosphorylation of glycogen synthase kinase-3s and inhibition of mitochondrial permeability transitionpore opening2012

    • Author(s)
      Onishi A, Miyamae M, Inoue H, Kaneda K, Okusa C, Inamura Y, Shiomi M, Koshinuma S, Momota Y, Figueredo VM
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: - Issue: 5 Pages: 916-924

    • DOI

      10.1053/j.jvca.2012.10.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembling peptide RADA16 as a scaffold in bone tissue engineering using dedifferentiated fat cells2011

    • Author(s)
      Kishimoto N, Momota Y, Hashimoto Y, Omasa T, Kotani J
    • Journal Title

      J Oral Tissue Engin

      Volume: 8 Pages: 151-161

    • NAID

      130004456616

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ミグゾラムを用いた静脈内鎮静法における性差について-若年者と高齢者における比較-2011

    • Author(s)
      三木麻莉
    • Journal Title

      日本歯科麻酔学会雑誌

      Volume: 39 Pages: 177-181

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembling Peptide RADA16 as a Scaffold in Bone Tissue Engineering Using Dedifferentiated Fat Cells.2011

    • Author(s)
      Kishimoto N.
    • Journal Title

      J Oral Tissue Engin

      Volume: 8 Pages: 151-161

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in blood pressure during induction of anesthesia and oral and maxillofacial surgery by type and timing of discontinuation of antihypertensive drugs2010

    • Author(s)
      Momota Y, Kaneda K, Arishiro K, Kishimoto N, Kanou S, Kotani J
    • Journal Title

      Anesth Prog

      Volume: 57 Issue: 1 Pages: 13-17

    • DOI

      10.2344/0003-3006-57.1.13

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes in blood pressure during induction of anesthesia and oral and maxillofacial surgery by type and timing of discontinuation of antihypertensive drugs.2010

    • Author(s)
      Momota Y.
    • Journal Title

      Anesth Prog

      Volume: 57 Pages: 13-17

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大脳皮質梗塞にともなう二次神経変性領域での内因性神経幹細胞の発現2013

    • Author(s)
      柴田啓貴
    • Organizer
      第38回日本脳卒中学会-STROKE2013
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス虚血再灌流モデルにおける神経幹細胞の発現の検討2012

    • Author(s)
      百田義弘
    • Organizer
      第22回日本脳循環代謝学会総会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)
    • Year and Date
      2012-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Cerebral protection effects of lidocaine using a transient cortical ischemia model2012

    • Author(s)
      Momota Y
    • Organizer
      13th International Dental Congress on Anesthesia, Sedation, and Pain Control
    • Place of Presentation
      Kona, Hawaii(USA)
    • Year and Date
      2012-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Lidocaine postconditioning attenuates myocardial infarct size in vivo rabbits hearts: role of extracellular signal-regulated kinase1/2 ERK 1/22012

    • Author(s)
      Yamabayashi K
    • Organizer
      13th International Dental Congress on Anesthesia, Sedation, and Pain Contro
    • Place of Presentation
      Kona, Hawaii(USA)
    • Year and Date
      2012-03-02
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス一過性虚血脳虚血誘導性 神経幹細胞の発現2012

    • Author(s)
      百田義弘
    • Organizer
      日本蘇生学会第31回大会
    • Place of Presentation
      ピアザ淡海(大津市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 一過性虚血脳虚血負荷により誘導される血管周皮細胞由来神経幹細胞2012

    • Author(s)
      百田義弘
    • Organizer
      第24回日本脳循環代謝学会総会
    • Place of Presentation
      リーガロイヤルホテル広島(広島市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 一過性脳虚血により誘導されるペリサイト由来神経幹細胞の発現2012

    • Author(s)
      百田義弘
    • Organizer
      第40回日本歯科麻酔学会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Related Report
      2012 Final Research Report
  • [Presentation] 一過性脳虚血により誘導されるぺリサイト由来神経幹細胞の発現2012

    • Author(s)
      百田義弘
    • Organizer
      第35回日本神経科学大会(Neuroscience2012)
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト脱分化脂肪細胞は脂肪幹細胞より骨芽細胞分化能が高い2012

    • Author(s)
      岸本直隆
    • Organizer
      第10回日本再生歯科医学会総会・学術大会
    • Place of Presentation
      ニチイ学館神戸ポートアイランドセンター(神戸市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of transient cortical ischemia induced neural stem/ progenitor cells in mice2012

    • Author(s)
      Momota Y
    • Organizer
      2012 Sino-Japan Dental Conference(日中歯科医学大会 2012)
    • Place of Presentation
      四川大学(中国・成都市)
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of transient cortical ischemia induced neural stem/progenitor cells in mice.2012

    • Author(s)
      Momota Y.
    • Organizer
      2012 Sino-Japan Dental Conference (日中歯科医学大会2012)
    • Place of Presentation
      四川大学(中国・成都市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト脱分化脂肪細胞は脂肪幹細胞より骨芽細胞分化能が高い2012

    • Author(s)
      岸本直隆
    • Organizer
      第10回日本再生歯科医学会総会・学術大会
    • Place of Presentation
      ニチイ学館 神戸ポートアイランドセンター(神戸市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一過性脳虚血により誘導されるペリサイト由来神経幹細胞の発現2012

    • Author(s)
      百田義弘
    • Organizer
      第35回日本神経科学大会 (Neuroscience 2012)
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一過性脳虚血により誘導されるペリサイト由来神経幹細胞の発現2012

    • Author(s)
      百田義弘
    • Organizer
      第40回日本歯科麻酔科学会
    • Place of Presentation
      アクロス福岡(福岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 一過性局所脳虚血負荷により誘導される血管周皮細胞由来神経幹細胞2012

    • Author(s)
      百田義弘
    • Organizer
      第24回日本脳循環代謝学会総会
    • Place of Presentation
      リーガロイヤルホテル広島(広島市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス一過性局所脳虚血誘導性神経幹細胞の発現2012

    • Author(s)
      百田義弘
    • Organizer
      日本蘇生学会第31回大会
    • Place of Presentation
      ピアザ淡海(大津市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Lidocaine postconditioning attenuates myocardial infarct size in vivo rabbits hearts : role of extracellular signal-regulated kinase 1/2 ERK 1/22012

    • Author(s)
      Yamabayashi K
    • Organizer
      13th International Dental Congress on Anesthesia, Sedation, and Pain Control
    • Place of Presentation
      Kona, Hawaii
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cerebral protection effects of lidocaine using a transient cortical ischemia model2012

    • Author(s)
      Momota Y
    • Organizer
      13th International Dental Congress on Anesthesia, Sedation, and Pain Control
    • Place of Presentation
      Kona, Hawaii
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脱分化脂肪細胞を用いた骨組織工学における自己組織化ペプチドRADA16の足場材料としての有用性2011

    • Author(s)
      岸本直隆
    • Organizer
      第8回日本再生歯科医学会学術大会・総会
    • Place of Presentation
      愛知学院大学(名古屋市)
    • Year and Date
      2011-10-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 脱分化脂肪細胞はTitaniumWebスキャホールド内で骨芽細胞へ分化する2011

    • Author(s)
      岸本直隆
    • Organizer
      第9回日本再生歯科医学会学術大会・総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2011-09-10
    • Related Report
      2012 Final Research Report
  • [Presentation] 脱分化脂肪細胞はTitanium Webスキャフォールド内で骨芽細胞へ分化する2011

    • Author(s)
      岸本直隆
    • Organizer
      第9回日本再生歯科医学会学術大会・総会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脱分化脂肪細胞と自己組織化ペプチドRADA16を用いた骨組織再生の検討2011

    • Author(s)
      岸本直隆
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-03-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 脱分化脂肪細胞と自己組織化ペプチドRADA16を用いた骨組織再生の検討2011

    • Author(s)
      岸本直隆
    • Organizer
      第10回日本再生医療学会総会
    • Place of Presentation
      京王プラザホテル(東京都・新宿)
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 一過性脳虚血誘導性神経幹細胞の発現2011

    • Author(s)
      百田義弘
    • Organizer
      第23回日本脳循環代謝学会総会
    • Place of Presentation
      都市センターホテル(東京都)
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Expression of neural stem cells induced by transient cortical ischemia in mice2011

    • Author(s)
      Momota Y
    • Organizer
      XXVth International Symposium on Cerebral Blood Flow, Metabolism, and Function
    • Place of Presentation
      Barcelona(Spain)
    • Related Report
      2012 Final Research Report
  • [Presentation] Expression of neural stem cells induced by transient cortical ischemia in mice2011

    • Author(s)
      Momota Y
    • Organizer
      XXVth International Symposium on Cerebral Blood Flow, Metabolism, and Function
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス虚血再灌流モデルにおける神経幹細胞発現の検討2010

    • Author(s)
      百田義弘
    • Organizer
      第22回日本脳循環代謝学会総会
    • Place of Presentation
      千里ライフサイエンスセンター(豊中市)
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脱分化脂肪細胞を用いた骨組繊工学における自己繊化ペプチドRADA16の足場材料2010

    • Author(s)
      岸本直隆
    • Organizer
      第8回日本再生歯科医学会学術大会
    • Place of Presentation
      愛知学院大学(名古屋市)
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Remote preconditioning by caotid artery occlusion limits myocardial infarct size: role of MAPK2010

    • Author(s)
      Arishiro K
    • Organizer
      American Society of Anesthesiologist Annual Meeting 2010
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2010-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Remote preconditioning by carotid artery occlusion limits myocardial infarct size: role of MAPK.2010

    • Author(s)
      Arishiro K.
    • Organizer
      American Society of Anesthesiologist Annual Meeting 2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] ウサギinvivo心筋虚血再灌流モデルを用いたリドカインの薬理学的ポストコンディショニング効果.2010

    • Author(s)
      百田義弘
    • Organizer
      第38回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      横須賀芸術劇場(横須賀市)
    • Year and Date
      2010-10-09
    • Related Report
      2012 Final Research Report
  • [Presentation] ウサギ in vivo 心筋虚血再灌流モデルを用いたリドカインの薬学的ポストコンディショニング効果2010

    • Author(s)
      百田義弘
    • Organizer
      第38回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      横須賀芸術劇場(横須賀市)
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス一過性脳虚血再灌流モデルを用いた神経細胞死発現時間の検討2010

    • Author(s)
      百田義弘
    • Organizer
      第38回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      横須賀芸術劇場(横須賀市)
    • Year and Date
      2010-10-08
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス-過性脳虚血再灌流モデルを用いた神経細胞死発現時間の検討2010

    • Author(s)
      百田義弘
    • Organizer
      第38回日本歯科麻酔学会総会・学術集会
    • Place of Presentation
      横須賀芸術劇場(横須賀市)
    • Year and Date
      2010-10-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Remote preconditioning by bilateral carotid artery occlusion limits myocardial infarct size in in vivo rabbit hearts : involvement of extracellular signal-regulated kinase 1/2 (ERK1/2)2010

    • Author(s)
      Arishiro K
    • Organizer
      European Society of Cardiology (EOS) Congress 2010
    • Place of Presentation
      Stockholm (Sweden)
    • Year and Date
      2010-08-29
    • Related Report
      2012 Final Research Report
  • [Presentation] Remote preconditioning by bilateral carotid artery occlusion limitsts myocardial infarct size in in vivo rabbit hearts : involvement of extracellular signal-regulated kinase 1/2 (ERK1/2).2010

    • Author(s)
      Arishiro K.
    • Organizer
      European Society of Cardiology (EOS) Congress 2010
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report
  • [Book] 歯科衛生士テキスト歯科麻酔学2013

    • Author(s)
      百田義弘 他
    • Total Pages
      127
    • Publisher
      学建書院
    • Related Report
      2012 Final Research Report
  • [Book] 歯科衛生士テキスト 歯科麻酔学(分担) 高血圧症 虚血性心疾患2013

    • Author(s)
      百田義弘
    • Total Pages
      127
    • Publisher
      学建書院
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi