A genome-wide association study for maxilla-facial deformity using pooled DNA typing

• Project/Area Number: 22592272
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Fukuoka Dental College (2012); Hokkaido University (2010-2011)
• Principal Investigator: KAJII Takashi 福岡歯科大学, 准教授 (60322822)
• Co-Investigator(Kenkyū-buntansha): 岡 晃 東海大学, 付置研究所, 講師 (80384866)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 歯科矯正学 / 基礎ゲノム科学 / ゲノムワイド関連解析 / pooled DNA / ゲノム関連解析 / 顎顔面変形症 / Dooled DNA

Research Abstract

At first, we conducted second screening of a genome-wideassociation study of mandibular prognathism. Over 10 of microsatellite markers showedsignificant association with mandibular prognathism from the result of second screening.Next we conducted individual typing (third screening) of a genome-wide association studyof mandibular prognathism. It was suggested that 1p22.3, 1q32.2, and 15q22.2 are candidateloci for mandibular prognathism.

Research Products

• [Journal Article] Congenital and postnatal factors inducing malocclusions in Japanese unilateral cleft lip and palate patients- determination using logistic regression analysis. (2013)
  • Author(s): Kajii TS, Alam MK, Mikoya T, Oyama A,Koshikawa-Matsuno M, Sugawara-Kato Y, Sato Y, Iida J
  • Journal Title: Cleft Palate-Craniofacial Journal Volume: 50
  • Peer Reviewed
• [Journal Article] 成長期の骨格性下顎前突症における下顎骨の過大な成長の予測-形態学的研究とゲノム解析を用いて-. (2012)
  • Author(s): 梶井貴史
  • Journal Title: 福岡歯科大学学会雑誌 Volume: 38巻 Pages: 139-144
  • NAID: 110009562432
• [Journal Article] Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion. (2012)
  • Author(s): Takahashi K, Kajii TS, Tsukamoto Y, Saito F, Wada S, Sugawara-Kato Y, Iida J
  • Journal Title: Orthodontics and Craniofacial Research Volume: 15 Pages: 84-91
  • Peer Reviewed
• [Journal Article] 成長期の骨格性下顎前突症における下顎骨の過大な成長の予測 ―形態学的研究とゲノム解析を用いて― (2012)
  • Author(s): 梶井 貴史
  • Journal Title: 福岡歯科大学学会雑誌 Volume: 38 Pages: 139-144
  • NAID: 110009562432
• [Journal Article] Histological study of the nasal septal cartilage in BALB/c-bm/bm mouse which spontaneously induces malocclusion (2012)
  • Author(s): Takahashi K, Kajii TS, et al
  • Journal Title: Orthodontics and Craniofacial Research Volume: 15(in press)
  • Peer Reviewed
• [Journal Article] Congenital and postnatal factors inducing malocclusions in Japanese unilateral cleft lip and palate patients- determination using logistic regression analysis (2012)
  • Author(s): Kajii TS, Alam MK, et al
  • Journal Title: Cleft Palate-Craniofacial Journal Volume: 49(in press)
  • Peer Reviewed
• [Journal Article] Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography. (2011)
  • Author(s): Saito F, Kajii TS, Sugawara-Kato Y,Tsukamoto Y, Arai Y, Hirabayashi Y,Fujimori O, Iida J
  • Journal Title: Orthodontics and Craniofacial Research Volume: 14 Pages: 100-106
  • Peer Reviewed
• [Journal Article] Three-dimensional cranio-maxillary characteristics of the mouse with spontaneous malocclusion using micro-computed tomography. (2011)
  • Author(s): Saito F, Kajii TS, Sugawara-Kato Y,Tsukamoto Y, Arai Y, Hirabayashi Y,Fujimori O, Iida J
  • Journal Title: European Journal of Orthodontics Volume: 33 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Morphological evaluation of cranial and maxillary shape differences of the brachymorphic mouse with spontaneous malocclusion using three-dimensional micro-computed tomography (2011)
  • Author(s): Saito F, Kajii TS, et al.
  • Journal Title: Orthodontics and Craniofacial Research Volume: 14 Pages: 100-106
  • Peer Reviewed
• [Journal Article] Three-dimensional cranio-maxillary characteristics of the mouse with spontaneous malocclusion using micro-computed tomography (2011)
  • Author(s): Saito F, Kajii TS, et al.
  • Journal Title: European Journal of Orthodontics Volume: 33 Pages: 43-49
  • Peer Reviewed
• [Journal Article] Relationship between degree of malocclusion and occlusal interference in mice that spontaneously develop anterior transverse crossbite. (2010)
  • Author(s): Tsukamoto Y, Kajii TS, Sugawara-Kato Y,Hirabayashi Y, Fujimori O, Iida J
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics Volume: 138
  • Peer Reviewed
• [Journal Article] Relationship between degree of malocclusion and occlusal interference in mice that spontaneously develop anterior transverse crossbite (2010)
  • Author(s): Tsukamoto Y, Kajii TS, et al.
  • Journal Title: American Journal of Orthodontics and Dentofacial Orthopedics Volume: 138
  • Peer Reviewed
• [Presentation] 下顎前突症(mandibular prognathism)のゲノムワイド関連解析 (2012)
  • Author(s): 生野啓一郎、梶井貴史、岡晃、斉藤文男、猪子英俊、石川博之、飯田順一郎
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
• [Presentation] 下顎前突症（mandibular prognathism）のゲノムワイド関連解析 (2012)
  • Author(s): 生野啓一郎
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
• [Presentation] Congenital and postnatal factors affecting malocclusions of Japanese unilateral cleft lip and palate patients-Using multivariate statistical analysis- (2011)
  • Author(s): Kajii TS, Sato Y, Iida J
  • Organizer: The meeting of the 20th anniversary celebration of sister school affiliation between Graduate School of Dental Medicine, Hokkaido University and School of Dentistry, Chonbuk National University
  • Place of Presentation: Haevichi Hotel (Korea)
  • Year and Date: 2011-07-01
• [Presentation] Congenital and postnatal factors affecting malocclusions of Japanese unilateral cleft lip and palate patients Using multivariate statistical analysis-. (2011)
  • Author(s): Kajii TS, Sato Y, Iida J
  • Organizer: The meeting of the 20th anniversary celebration of sister school affiliation between Graduate School of Dental Medicine
  • Place of Presentation: Hokkaido University and School of Dentistry,Chonbuk National University, Jeju
• [Presentation] 顎変形症の発症原因解明に対する考察-顎変形症自然発症モデル動物を用いて- (2010)
  • Author(s): 梶井貴史、飯田順一郎
  • Organizer: 第20回日本顎変形症学会総会