Analysis of pathological and/or unphysiological root resorption mechanism focused on the two types of osteoclasts

• Project/Area Number: 22592274
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Hokkaido University
• Principal Investigator: YOSHIMURA Yoshitaka 北海道大学, 大学院・歯学研究科, 助教 (30230816)
• Co-Investigator(Kenkyū-buntansha): DOMON Takanori 北海道大学, 大学院・歯学研究科, 教授 (50217618) ; KIKUIRI Takashi 北海道大学, 大学院・歯学研究科, 助教 (10322819)
• Co-Investigator(Renkei-kenkyūsha): DEYAMA Yoshiaki 北海道大学, 大学院・歯学研究科, 准教授 (80271667) ; HASEGAWA Tomokazu 徳島大学, 大学病院, 講師 (50274668)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 破骨細胞 / 歯学 / 歯根吸収

Research Abstract

In this study, we examined the pathological and/or unphysiologicalroot resorption mechanism focused on the two types of osteoclasts. Our results weresuggested that morphologic characteristics of the osteoclasts varied according to thedown-regulation of Treg activity, difference of the major histocompatibility complex(MHC) haplotype, tensile force in culture condition and ROS scavengers.

Research Products

• [Journal Article] Short-term mechanical stress inhibits osteoclastogenesis via suppression of DC-STAMP in RAW264.7 cells (2013)
  • Author(s): Sumika Kameyama, Yoshitaka Yoshimura,Takeshi Kameyama, Takashi Kikuiri, Mino Matsuno, Yoshiaki Deyama, Kuniaki Suzuki,Junichiro Iida
  • Journal Title: International Journal of Molecular Medicine Volume: 31巻 Issue: 2 Pages: 292-298
  • DOI: 10.3892/ijmm.2012.1220
  • Peer Reviewed
• [Journal Article] Effects of bisphosphonates on osteoclastogenesis in RAW264.7 cells (2012)
  • Author(s): Abe K, Yoshimura Y, Deyama Y, et al
  • Journal Title: International Journal of Molecular Medicine Volume: 29 Pages: 1007-1015
  • DOI: 10.3892/ijmm.2012.952
  • Peer Reviewed
• [Journal Article] Stage-dependent suppression of the formation of dentin-resorbing multinuclear cells with MIF in vitro (2011)
  • Author(s): Kikuiri T, Yoshimura Y, Tabata F, Hasegawa T, Nishihira J, Shirakawa T
  • Journal Title: Experimental and Therapeutic Medicine Volume: 3 Issue: 1 Pages: 37-43
  • DOI: 10.3892/etm.2011.362
  • Peer Reviewed
• [Journal Article] Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells (2011)
  • Author(s): Nomura M, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Koshiro K, Sano H, Suzuki K, Inoue N.
  • Journal Title: Journal of Pharmacological Sciences Volume: 117 Issue: 4 Pages: 243-252
  • DOI: 10.1254/jphs.11099FP
  • NAID: 10030453660
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] Effect of the release from mechanical stress on osteoclastogenesis in RAW 264. 7 cells (2011)
  • Author(s): Shibata K, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Suzuki K, Iida J.
  • Journal Title: Int J Molecular Medicin Volume: 28 Pages: 73-79
  • DOI: 10.3892/ijmm.2011.675
  • Peer Reviewed
• [Journal Article] Effect of the release from mechanical stress on osteoclastogenesis in RAW264.7 cells. (2011)
  • Author(s): Kenjiro Shibata
  • Journal Title: International Journal of Molecular Medicine Volume: (印刷中,印刷中)
  • Peer Reviewed
• [Presentation] 破骨細胞分化に対する白金ナノコロイドの影響 (2010)
  • Author(s): 野村真有美
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-09-21
• [Presentation] 機械的刺激からの解放が破骨細胞分化に与える影響 (2010)
  • Author(s): 芝田健二郎
  • Organizer: 第52回歯科基礎医学会学術大会
  • Place of Presentation: タワーホール船堀(東京都)
  • Year and Date: 2010-09-21