Evaluation of roles of Ten-m/Odz3 in periodontal ligament during orthodontic tooth movement.

• Project/Area Number: 22592277
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: YUICHI Sakai 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (00451609)
• Co-Investigator(Kenkyū-buntansha): TOMOHIRO Hukunaga 東北大学, 病院, 講師 (70362994)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Ten-m/Odz3 / 歯根膜 / 機械的刺激 / 歯の移動 / 圧迫側 / マウス歯根膜 / Tem-m/Odz3 / 遺伝子発現

Research Abstract

Peirodotal ligament (PDL) maintains unmineralized status to exert its functions; however, the molecular mechanisms are unknown. In this study, we focused on Ten-m/Odz3 to clarify molecular mechanism upon PDL homeostasis. As a result, Ten-m/Odz3 expression was shown in PDL. Moreover, the expression pattern was changed by mechanical stress. These findings suggest that Ten-m/Odz3 possibly regulates cellularevents in PDL.

Research Products

• [Journal Article] A case report of multidisciplinary treatment of an adult patient with bilateral cleft lip and palate (2012)
  • Author(s): Fukunaga T, Honjo T, Sakai Y, Sasaki K, Takano-Yamamoto T, Yamashiro T.
  • Journal Title: The Cleft Palate-Craniofacial Jounal Volume: (未定)(accepted)
  • Peer Reviewed
• [Journal Article] A case report of multidisciplinary treatment of an adult patient with bilateral cleft lip and palate (2011)
  • Author(s): Fukunaga T, Honjo T, Sakai Y, Sasaki K, Takano-Yamamoto T, Yamashiro T.
  • Journal Title: Cleft Palate Craniofac J Volume: (in press)
  • Peer Reviewed
• [Journal Article] Sox9 expression during fracture repair (2011)
  • Author(s): Shintaku Y., Murakami T., Yanagita T., Kawanabe N., Fukunaga T., Matsuzaki K., Uematsu S., Yoshida Y., Kamioka H., Takano-Yamamoto T., Takada K., Yamashiro T
  • Journal Title: Cells Tissues Organs Volume: 194 Issue: 1 Pages: 38-48
  • DOI: 10.1159/000322557
  • Peer Reviewed
• [Journal Article] Expression of Ten-m/Odz3 in the fibrous layer of mandibular condylar cartilage during postnatal growth in mice (2010)
  • Author(s): Murakami T, Fukunaga T, Takeshita N, Hiratsuka K., Abiko Y, Yamashiro T, Takano-Yamamoto T
  • Journal Title: Journal of Anatomy Volume: 217 Issue: 3 Pages: 236-244
  • DOI: 10.1111/j.1469-7580.2010.01267.x
  • Peer Reviewed
• [Journal Article] 骨格性下顎前突症例における固定源としてのミニスクリューの応用 (2010)
  • Author(s): 宮島悠旗、出口徹、酒井雄一、山本照子
  • Journal Title: 東北矯正歯科学会雑誌 Volume: 18 Pages: 11-21
  • Peer Reviewed
• [Journal Article] メカニカルストレスと骨細胞 (2010)
  • Author(s): 山本照子、川木晴美、鈴木誠、MURSHIDSA、福永智広
  • Journal Title: 東北大学歯学雑誌 Volume: 29(1) Pages: 32-32
  • Peer Reviewed
• [Presentation] Effects of CO2 laser irradiation on the distribution of Fos protein in the medullary dorsal horn (2011)
  • Author(s): Seiryu M, Deguchi T, Fujiyama K, Sakai Y, Daimaruya T, Takano-Yamamoto T
  • Organizer: Harvard-Forsyth-Tohoku Research Workshop
  • Place of Presentation: Boston, USA
  • Year and Date: 2011-01-07
• [Presentation] 成人両側性口唇口蓋裂症例の形態的、機能的改善と長期保定 (2010)
  • Author(s): 福永智広、本城正、酒井雄一、山本照子、山城隆
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: 横浜
• [Presentation] ミニスクリューを用いて下顎歯列弓遠心移動を行った下顎前突症例 (2010)
  • Author(s): 宮島悠旗、出口徹、酒井雄一、山本照子
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: 横浜
• [Presentation] インプラントアンカーを用いて治療した成人性歯周炎を伴う上顎前突症 (2010)
  • Author(s): 福永智広、黒田晋吾、黒坂寛、山本照子
  • Organizer: 第2回機能的顎治療を考える会
  • Place of Presentation: 郡山
• [Presentation] 成人両側性口唇口蓋裂症例の形態的、機能的改善と長期保定 (2010)
  • Author(s): 福永智広
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] ミニスクリューを用いて下顎歯列弓遠心移動を行った下顎前突症例 (2010)
  • Author(s): 宮島悠旗
  • Organizer: 第69回日本矯正歯科学会大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Book] Interface Oral Health Science 2011 (2012)
  • Author(s): Takeshita N, Fukunaga T, et al
  • Publisher: Springer