Analysis of the cellular mechanism of biomechanical signaling regulating the periodontal tissue remodeling
| Project/Area Number |
22592278
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
CHIBA Mirei 東北大学, 大学院・歯学研究科, 講師 (10236820)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Yoshinaka 東北大学, 大学院・歯学研究科, 助教 (30302152)
KUDO Tada-aki 東北大学, 大学院・歯学研究科, 助教 (50431606)
SHINODA Hisashi 東北大学, 大学院・歯学研究科, 大学院非 常勤講師 (80014025)
HAYASHI Haruhide 東北大学, 大学院・歯学研究科, 大学院非 常勤講師 (90107293)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 骨改造 / シグナル伝達 / 歯周組織 / マイクロアレイ / バイオメカニクス / 歯根膜細胞 / 骨芽細胞 / 超音波 / 細胞接着 / インテグリン / TGF-β / 細胞外マトリックス / actin / メカニカルストレス |
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| Research Abstract |
The aims of this study were to investigate the mechanical-stress-induced gene expression patterns by gene profiling using microarray analysis in the cells of periodontal tissue, and to select the functionally effective molecules to regulate the bone remodeling, and then to establish the transfer method of selected gene into the periodontal tissue. The expression pattern analysis suggested that both properties common among cells and cell-specific properties affect the remodeling mechanism of periodontal tissues in response to mechanical stress. Moreover several signal pathways were identified as candidates. A non-viral gene delivery approach with nano/microbubbles and ultrasound were established for targeting soft tissues.
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Report
(4 results)
Research Products
(51 results)
