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Load frequency to temporomandibular joint brings about the osteoarthritis through the asporin expression in the articular cartilage

Research Project

Project/Area Number 22592294
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionTokyo Medical and Dental University (2011-2012)
Yokohama City University (2010)

Principal Investigator

YONEMITSU Ikuo  東京医科歯科大学, 医歯学総合研究科, 助教 (00431940)

Co-Investigator(Kenkyū-buntansha) YABUSHITA Tadachika  東京医科歯科大学, 医歯学総合研究科, 非常勤講師 (40420260)
TAKEI Maki  東京医科歯科大学, 医歯学総合研究科, 非常勤講師 (50547445)
Research Collaborator HATTORI Ikuko  , 医員
KURODA Yukiko  , 大学院生
MIYAZAKI Mutsumi  , 大学院生
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords顎関節 / asporin / OA / アスポリン / 負荷頻度 / 下顎頭軟骨
Research Abstract

In the experimental group, unilateral masseter muscles of 5-week-old rats were resected to represent the animal model of deviated mandible. Two and four weeks after muscle resection, their condyles were observed to detect whether OA-like change occurs. Micro-CTwas used for three-dimensional morphological analysis. In the experimental group, the cancellous bone volume and bone density of the condyles were decreased in the resected side. For histological examination, the specimens were embedded in paraffin and5-μm-thick serial frontal sections of the TMJ were stained with toluidine blue. As a result, the morphological changes of cartilage layers were similar to the past mandibular functional lateral shift model. Furthermore, immunohistochemical staining of asporinwhich are OA-related protein and of TGF-b1 which participates in cartilage repair were performed. We revealed that the expression of asporin in the temporomandibular joint cartilage in the OA-like animal model

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Effect of functional shift of the mandible on lubrication of the temp oromandibular joint.2012

    • Author(s)
      Ikuko Kure-Hattori,Ippei Watari,Mak i Takei,Yuji Ishida,Ikuo Yonemitsu,Taka shi Ono.
    • Journal Title

      Archives of Oral B iology

      Volume: 57(7) Pages: 987-94

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of functional shift of the mandible on lubrication of the temporomandibular joint.2012

    • Author(s)
      Ikuko Kure-Hattori,Ippei Watari,Maki Takei,Yuji Ishida,Ikuo Yonemitsu,Takashi Ono.
    • Journal Title

      Archives of Oral Biology

      Volume: Jul;57(7) Issue: 7 Pages: 987-94

    • DOI

      10.1016/j.archoralbio.2012.01.006

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In termittent posterior displacement of the rat mandible in the growth period a ffects the condylar cancellous bone.2011

    • Author(s)
      Kuroda Y, Yonemitsu I, Hosomichi J, Watari I, Takei M, Ishida Y, Ono T.
    • Journal Title

      An gle Orthodontist

      Volume: 81(6) Pages: 975-82

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intermittent posterior displacement of the rat mandible in the growth period affects the condylar cancellous bone2011

    • Author(s)
      Kuroda Y, Yonemitsu I, Hosomichi J, Watari I, Takei M, Ishida Y, Ono T
    • Journal Title

      Angle Orthodontist

      Volume: Nov;81(6) Issue: 6 Pages: 975-82

    • DOI

      10.2319/122810-749.1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of functional shift of the mandible on lubrication of the temporo mandibular joint2011

    • Author(s)
      Ikuko Kure-Hattori, Ippei Watari, Maki Takei, Yuji Ishida, Ikuo Yonemitsu, Takashi Ono
    • Journal Title

      Archives of Oral Biology

      Volume: (In press) Pages: 9879-94

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Imbalanced masticatory muscle activity leads to laterality of condylar growth2013

    • Author(s)
      Mutsumi Miyazaki, Ikuo Yonemitsu, Ikuko Kure-Hattori, Takashi Ono
    • Organizer
      89th Congress of the European Orthodontic Society
    • Place of Presentation
      Reykjavik, Iceland
    • Related Report
      2012 Final Research Report
  • [Presentation] Imbalanced masticatory muscle activity leads to laterality of condylar growth2013

    • Author(s)
      Mutsumi Miyazaki, Ikuo Yonemitsu, Ikuko Kure-Hattori, Takashi Ono
    • Organizer
      89 th Congress of the European Orthodontic Society
    • Place of Presentation
      Reykjavik, Iceland
    • Related Report
      2012 Annual Research Report
  • [Presentation] 成長期の下顎骨機能的側方偏位が顎関節潤滑能に及ぼす影響について2011

    • Author(s)
      服部育子、渡一平、武居真希、石田雄之、米満郁男、小野卓史
    • Organizer
      第76回口腔病学会学術大会
    • Place of Presentation
      東京医科歯科大学
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 成長期における咀嚼筋力低下がラット下顎頭軟骨下骨に与える影響2010

    • Author(s)
      武居真希,米満郁男,渡一平,小野卓史
    • Organizer
      日本矯正歯科学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2012 Final Research Report 2010 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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