Establishment of periodontal ligament (PDL) cells derived from deciduous teeth and periodontal tissue regeneration with PDL cells.
| Project/Area Number |
22592296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | The University of Tokushima (2011-2012)
Iwate Medical University (2010) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHISAKI Akira 岩手医科大学, 歯学部, 教授 (20356439)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 小児歯科学 / 乳歯 / 歯根膜 / 株化 / hTERT / 再生医学 / SDF-1 |
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| Research Abstract |
We established clonal cell lines of periodontal ligament cells derived from human deciduous teeth immortalized by hTERT gene transfer. SH 9 cells showed the ability of differentiation into both osteoblasts and adipocytes. Stromal cell-derived factor-1α(SDF-1) has important roles in migration of mesenchymal stem cells and endothelial progenitor cells. We reported that SDF-1 expression in SH 9 cells was regulated by various cytokines.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Platinum Nanoparticles Suppress Osteoclastogenesis Through Scavenging of Reactive Oxygen Species Produced in RAW264.7 Cells2011
Author(s)
Nomura M, Yoshimura Y, Kikuiri T, Hasegawa T, Taniguchi Y, Deyama Y, Koshiro K, Sano H, Suzuki K, Inoue N.
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Journal Title
Journal of Pharmacological Sciences
Volume: 117
Issue: 4
Pages: 243-252
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed
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