The examination of the expression of chemokines and RANKL in root resorption during orthodontic tooth movement
| Project/Area Number |
22592297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯科矯正 / 歯根吸収 / ケモカイン / RANKL / 歯科矯正学 / IL-8 / MCP-1 / excessive orthodontic force / root resorotion / odontoclastogenesis / root resorption |
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| Research Abstract |
The immunoreactivity for CINC-1/CXCR2 , MCP-1 and RANKL were detected in odontoclasts and PDL fibroblasts by the orthodontic force of 50 g on day 7. CF increased the production of IL-8, MCP-1 and RANKL from hPDL cells in a magnitude-dependent manner. Moreover, CINC-1,MCP-1 and RANKL stimulated osteoclastogenesis from rat osteoclast precursor cells.Conclusion: IL-8 (CINC-1), MCP-1 and RANKL may facilitate the process of root resorptiondue to excessive orthodontic force.
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Report
(4 results)
Research Products
(35 results)
