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The examination of the expression of chemokines and RANKL in root resorption during orthodontic tooth movement

Research Project

Project/Area Number 22592297
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionNihon University

Principal Investigator

YAMAGUCHI Masaru  日本大学, 松戸歯学部, 准教授 (60333100)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords歯科矯正 / 歯根吸収 / ケモカイン / RANKL / 歯科矯正学 / IL-8 / MCP-1 / excessive orthodontic force / root resorotion / odontoclastogenesis / root resorption
Research Abstract

The immunoreactivity for CINC-1/CXCR2 , MCP-1 and RANKL were detected in odontoclasts and PDL fibroblasts by the orthodontic force of 50 g on day 7. CF increased the production of IL-8, MCP-1 and RANKL from hPDL cells in a magnitude-dependent manner. Moreover, CINC-1,MCP-1 and RANKL stimulated osteoclastogenesis from rat osteoclast precursor cells.Conclusion: IL-8 (CINC-1), MCP-1 and RANKL may facilitate the process of root resorptiondue to excessive orthodontic force.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2013 2012 2011 2010

All Journal Article (20 results) (of which Peer Reviewed: 11 results) Presentation (14 results) Book (1 results)

  • [Journal Article] IL-17/Th17 cells in an atopic dermatitis mouse model aggravate orthodontic root resorption in dental pulp.2013

    • Author(s)
      Shimizu M, Yamaguchi M, Utsunomiya M, Yamamoto H, Kasai K.
    • Journal Title

      Eur J Oral Sci

      Volume: 121(2) Issue: 2 Pages: 101-10

    • DOI

      10.1111/eos.12024

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological and Histological Changes in the Mandibular Condyle after Plate Removal in Experimental Models of Short- and Long-term Mandibular Lateral Displacement.2013

    • Author(s)
      Ando J, Yamaguchi M, Fujita S, KawamuraA, Utsunomiya T, Kasai K.
    • Journal Title

      J Hard Tissue Biol

      Volume: 22 Pages: 201-210

    • NAID

      130004480580

    • Related Report
      2012 Final Research Report
  • [Journal Article] Effect of compression force on apoptosis in human periodontal ligament cells.2013

    • Author(s)
      Funakoshi M, Yamaguchi M, Asano M,Kasai K.
    • Journal Title

      J Hard Tissue Biol

      Volume: 22 Pages: 41-50

    • NAID

      130004848409

    • Related Report
      2012 Final Research Report
  • [Journal Article] Immunohistochemical localization of T-helper 17 cells, IL-17, and RANKL during root resorption induced by excessive orthodontic force in a mouse model of T cell-mediated autoimmune disease2013

    • Author(s)
      Yamaguchi M, Yamada M, Asano M, Fujita S, Kasai K.
    • Journal Title

      Int J Oral-Med Sci,

      Volume: 11(4) Pages: 249-260

    • NAID

      130003375182

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of compression force on apoptosis in human periodontal ligament cells2013

    • Author(s)
      Funakoshi M, Yamaguchi M, Asano M, Kasai K.
    • Journal Title

      J Hard Tissue Biol

      Volume: 22(1) Pages: 41-50

    • NAID

      130004848409

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th17-cells in atopic dermatitis stimulate orthodontic root resorption.2012

    • Author(s)
      Yamada K, Yamaguchi M, Asano M, FujitaS, Kobayashi R, Kasai K.
    • Journal Title

      Oral Dis

      Volume: 19 Issue: 7 Pages: 683-693

    • DOI

      10.1111/odi.12053

    • Year and Date
      2012-12-25
    • Related Report
      2012 Final Research Report
  • [Journal Article] Immunohistochemical localization of T-helper 17 cells, IL-17, and RANKL during root resorption induced by excessive orthodontic force in a mouse model of T cell-mediated autoimmune disease.2012

    • Author(s)
      Yamaguchi M, Yamada M, Asano M, Fujita S, Kasai K.
    • Journal Title

      Int J Oral-Med Sci

      Volume: 11 Pages: 249-260

    • NAID

      130003375182

    • Related Report
      2012 Final Research Report
  • [Journal Article] Localization of TNF-α andmacrophages in the periodontalligament during orthodontic tooth movement.2012

    • Author(s)
      Funakoshi M, Yamaguchi M, Fujita S,Kasai K.
    • Journal Title

      Int J Oral-Med Sci

      Volume: 11 Pages: 182-181

    • Related Report
      2012 Final Research Report
  • [Journal Article] Orthodontic root resorption was associated with the secretion of IL-6 and IL-8 stimulated by IL-17 in dental pulp cells.2012

    • Author(s)
      Shimizu M, Yamaguchi M, Asano M, FujitaS, Utsunomiya T, Yamamoto H, Kasai K.
    • Journal Title

      Int J Oral-Med Sci

      Volume: 11 Pages: 172-189

    • Related Report
      2012 Final Research Report
  • [Journal Article] T-helper 17 cells mediate the osteo/odontoclastogenesis induced by excessive orthodontic forces.2012

    • Author(s)
      Hayashi N, Yamaguchi M, Nakajima R,Utsunomiya T, Yamamoto H, Kasai K.
    • Journal Title

      Oral Dis

      Volume: 18(4) Pages: 375-388

    • Related Report
      2012 Final Research Report
  • [Journal Article] Mechanoreceptors, nociceptors and orthodontic tooth movement.2012

    • Author(s)
      Yamaguchi M, Nakajima R, Kasai K.
    • Journal Title

      Semin Orthod.

      Volume: 18(4) Issue: 4 Pages: 249-256

    • DOI

      10.1053/j.sodo.2012.06.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] T-helper 17 cells mediate the osteo/odontoclastogenesis induced by excessive orthodontic forces.2012

    • Author(s)
      Hayashi N, Yamaguchi M, Nakajima R, Utsunomiya T, Yamamoto H, Kasai K.
    • Journal Title

      Oral Dis.

      Volume: 18(4) Issue: 4 Pages: 375-388

    • DOI

      10.1111/j.1601-0825.2011.01886.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orthodontic root resorption was associated with the secretion of IL-6 and IL-8 stimulated by IL-17 in dental pulp cells.2012

    • Author(s)
      Shimizu M, Yamaguchi M, Asano M, Fujita S, Utsunomiya T, Yamamoto H, Kasai K.
    • Journal Title

      Int J Oral-Med Sci,

      Volume: 11(3) Pages: 172-181

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization of TNF-α and macrophages in the periodontal ligament during orthodontic tooth movement.2012

    • Author(s)
      Funakoshi M, Yamaguchi M, Fujita S, Kasai K.
    • Journal Title

      Int J Oral-Med Sci

      Volume: 11(3) Pages: 182-189

    • NAID

      130003375171

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-6 and IL-17 in gingival crevicular fluid during orthodontic root resorption2012

    • Author(s)
      Yamaguchi Y, Nariyasu T, Hayashi N, Nakajima R, Fujita S, Yamaguchi M, Kasai K
    • Journal Title

      International Journal of Oral-Medical Sciences

      Volume: 10 Pages: 247-254

    • NAID

      130002051659

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-8 and MCP-1 induced by excessive orthodontic force mediates odontoclastogenesis in periodontal tissues.2011

    • Author(s)
      Asano M, Yamaguchi M, Nakajima R,Fujita S, Utsunomiya T, Yamamoto H, Kasai K.
    • Journal Title

      Oral Dis

      Volume: 17(5) Pages: 489-498

    • Related Report
      2012 Final Research Report
  • [Journal Article] Expressions of RANKL/RANK and M-CSF/c-fms in root resorption by excessive orthodontic force.2011

    • Author(s)
      Nakano Y, Yamaguchi M, Fujita S, AsanoM, Saito K, Kasai K.
    • Journal Title

      Eur J Orthod.

      Volume: 33(4) Pages: 335-343

    • Related Report
      2012 Final Research Report
  • [Journal Article] IL-8 and MCP-1 induced by excessive orthodontic force mediates odontoclastogenesis in periodontal tissues2011

    • Author(s)
      Asano M, Yamaguchi M, Nakajima R, Fujita S, Utsunomiya T, Yamamoto H, Kasai K
    • Journal Title

      Oral Diseases

      Volume: 17 Issue: 5 Pages: 489-498

    • DOI

      10.1111/j.1601-0825.2010.01780.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Relaxin on Relapse After Experimental Tooth Movement in Rats2011

    • Author(s)
      Hirate Y, Yamaguchi M, Utsunomiya T, Yamamoto H, Kasai K
    • Journal Title

      International Journal of Oral-Medical Sciences

      Volume: 10 Pages: 200-210

    • NAID

      130002051651

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of HSP70 on the compression force-induced TNF-α and RANKL expression in human periodontal ligament cells.2010

    • Author(s)
      Mitsuhashi M, Yamaguchi M, Kojima T, Nakajima R, Kasai K.
    • Journal Title

      Inflammation Research

      Volume: 60 Pages: 187-194

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト歯髄組織中のIL-17が炎症性サイトカイン産生および歯根吸収に及ぼす影響.2012

    • Author(s)
      清水真美,山口大,浅野正貴,葛西一貴.
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡.
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] アレルギーは矯正学的歯の移動時に生じる歯根吸収を増悪する.2012

    • Author(s)
      山田邦彦,山口大,小林良喜,浅野正貴,安藤淳,宇都宮忠彦,山本正文,山本浩嗣,葛西一貴.
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] メカニカルストレスがヒト歯根膜線維芽細胞の細胞死に与える影響.2012

    • Author(s)
      船越麻理,山口大,小林良喜,浅野正貴,葛西一貴.
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] TNF-αが矯正学的歯の移動時に生じる歯根吸収に及ぼす影響.2012

    • Author(s)
      吉野智一,山口大,菊田純,葛西一貴.
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      盛岡.
    • Year and Date
      2012-09-27
    • Related Report
      2012 Final Research Report
  • [Presentation] 次世代歯科矯正学の研究シーズ戦略-歯根吸収発現予測診断と後戻り抑制薬-.2012

    • Author(s)
      山口大.
    • Organizer
      BIOtech2012第11回バイオテクノロジー展/技術会議
    • Place of Presentation
      東京
    • Year and Date
      2012-04-25
    • Related Report
      2012 Final Research Report
  • [Presentation] アレルギーは矯正学的歯の移動時に生じる歯根吸収を増悪する2012

    • Author(s)
      山田 邦彦、山口 大、小林 良喜、浅野 正貴、安藤 淳、宇都宮 忠彦、山本 正文、山本 浩嗣、葛西 一貴
    • Organizer
      第71回 日本矯正歯科学会大会
    • Place of Presentation
      盛岡市アイスアリーナ, 岩手
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒト歯髄組織中のIL-17が炎症性サイトカイン産生および歯根吸収に及ぼす影響2012

    • Author(s)
      清水 真美、山口 大、浅野 正貴、葛西 一貴
    • Organizer
      第71回 日本矯正歯科学会大会
    • Place of Presentation
      盛岡市アイスアリーナ, 岩手
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯根吸収発現予測における歯肉溝滲出液の有用性2011

    • Author(s)
      山口大
    • Organizer
      第70回日本矯正歯科学会大会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] K.HSP70 inhibits the compressionforce-induced TNF-α and RANKL expression.2011

    • Author(s)
      Yamaguchi M, Mituhashi M, kasai
    • Organizer
      10th World of congress on inflammation
    • Place of Presentation
      paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] Effects of IL-17 on the expression ofRANKL from human dental pulp cells.2011

    • Author(s)
      Shimizu M, Yamaguchi M, kasai K.
    • Organizer
      10th World of congress on inflammation
    • Place of Presentation
      paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-8/RANKL increasedIL-8/RANKL increased by excessive orthodonticforce in periodontal ligament induces orthodontically-induced inflammatory root resorption.2011

    • Author(s)
      Funakoshi M, Yamaguchi M, Asano M,nakojima R, Fujita S, kasai K.
    • Organizer
      10th World of congress on inflammation
    • Place of Presentation
      paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] The participation of interleukin 17 and RANKL in root resorption of the allergic mouce.2011

    • Author(s)
      Yamada K, Yamaguchi M, Fujita S, AsanoM, Ando J, Utsunomiya T, Yamamoto H, kasai K.
    • Organizer
      10th World of congress on inflammation
    • Place of Presentation
      paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-17stimulates IL-6 productionand osteoclastogenesis in human periodontal ligament cells.2011

    • Author(s)
      Hayashi N, Yamaguchi M, kasai K.
    • Organizer
      10th World of congress on inflammation
    • Place of Presentation
      paris, France
    • Related Report
      2012 Final Research Report
  • [Presentation] 矯正学的歯の移動時に生じる歯根吸収におけるケモカイン発現の検討2010

    • Author(s)
      浅野正貴、山口大、中嶋亮、藤田祥仁、宇都宮忠彦、山本浩嗣、葛西一貴
    • Organizer
      第52回 日本歯科基礎医学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Book] In Principles in Contemporary Orthodontics.2011

    • Author(s)
      Yamaguchi M,他
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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