| Project/Area Number |
22592301
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | Tsurumi University |
|---|
Principal Investigator |
NODA Koji 鶴見大学, 歯学部, 臨床教授 (10148059)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ARAI Chihiro 鶴見大学, 歯学部, 助教 (10460221)
中村 芳樹 鶴見大学, 歯学部, 教授 (10097321)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 断続的矯正力 / 強い圧迫 / 弱い圧迫 / 歯根膜 / 血管関連遺伝子 / 免疫組織化学 / 網羅的遺伝子解析 / 歯の移動 / 血管組織 / VEGF / bFGF / SAPK/JNK / ICAM-1 / FGF-2 |
|---|
| Research Abstract |
In the immunohistochemical findings and comprehensive geneexpression related in blood vessels of periodontal ligament (PDL) using experimental toothmovement by Waldo’s method, gene expression ratio increased notably at 6 hours aftertooth movement in both experimental groups with and without degenerating tissue, andthe former showed the higher ratio compared to the later. It was suggested that orthodonticforce which is induced degenerating tissue promotes vascular formation, leading to anefficient tooth movement.
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