Elucidation of molecular regulation mechanism and promotion of the orthodontic remodeling using the bone marrow stem cell
| Project/Area Number |
22592303
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Keisuke 松本歯科大学, 歯学部, 准教授 (10325095)
TOMIDA Mihoko 松本歯科大学, 歯学部, 准教授 (00366329)
KAWAKAMI Toshiyuki 松本歯科大学, 総合歯科医学研究所, 教授 (80104892)
TSUJIGIWA Hidetsugu 岡山大学, 医歯(薬)学総合研究科, 准教授 (70335628)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | メカニカルストレス / 細胞分化 / 免疫組織化学 / 遺伝子発現 / シグナリング / Runx2 / Msx2 / 歯周組織 / 骨髄幹細胞 / 歯科矯正学 / リモデリング / 外傷 / 組織修復 / 再生 / GFP / 移植 / 細胞移動 |
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| Research Abstract |
We demonstrated the following results in this study.1. Bone marrow stem cells have a potential to differentiate into dental pulp cells and periodontal ligament cells.2. Bone marrow stem cells engraft in the active remodeling tissues.3. Peripheral nerves are involved in the migration of bone marrow stem cells.4. These results can be applied to development of new orthodontic treatment and the effective treatment of the injury.
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Report
(4 results)
Research Products
(57 results)
