Development of the bone substitute material for alveolar bone regeneration during tooth movement

• Project/Area Number: 22592306
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Osaka Dental University
• Principal Investigator: MATSUMOTO Naoyuki 大阪歯科大学, 歯学部, 教授 (70199884)
• Co-Investigator(Kenkyū-buntansha): BABA Shunsuke 大阪歯科大学, 歯学部附属病院, 教授 (40275227)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 歯科矯正学 / 生体材料学 / 組織工学 / 人工コラーゲン / α-TCP / 生体吸収材料 / 歯周組織再生 / 歯槽骨再生

Research Abstract

Implantable scaffolds of the chemical synthesis of collagen model polypeptides consisting of a Pro-Hyp-Gly [poly(PHG)] sequence for tissue regeneration need to be biodegradable, have no ability to induce inflammation and to act as a scaffold for cell proliferation and differentiation. The combining poly(PHG) and alpha-tricalcium phosphate particles, or mesenchymal stem cells showed extremely rapid bone regeneration in a calvarial defect model in mini-pigs.

Research Products

• [Journal Article] Evaluation of bone regeneration by porous alpha-tricalcium phosphate/atelocollagen sponge composite in rat calvarial defects (2013)
  • Author(s): Arima Y
  • Journal Title: Orthodontic Waves Volume: 72 Issue: 1 Pages: 23-29
  • DOI: 10.1016/j.odw.2012.11.001
  • Peer Reviewed
• [Journal Article] Evaluation of Bone Regeneration of Apatite Coating Poly-L-lactide Scaffold in RatCalvarial Defects. (2012)
  • Author(s): Kenichirou Yasui, Yoshiya Hashimoto,Shunsuke Baba, Shigeki Hontsu, Naoyuki Matsumoto
  • Journal Title: Nano Biomed Volume: 4(2) Pages: 133-142
  • NAID: 130004679848
  • Peer Reviewed
• [Journal Article] Evaluation of bone regeneration of apatite coating poly-L-lactide scaffold in rat calvarial defects (2012)
  • Author(s): Kenichirou Yasui
  • Journal Title: Nano Biomedicine Volume: 4(2) Pages: 133-142
  • Peer Reviewed
• [Journal Article] Effect of p38 MAP kinase on the production of MAP-1 in human gingival fibroblast-like cells (2012)
  • Author(s): 氏井庸介
  • Journal Title: ORTHODONTIC WAVES Volume: 71 Pages: 26-30
  • Peer Reviewed
• [Journal Article] Bone regeneration efficacy of bone m arrow-derived mesenchymal stem cells in a 3-D woven fabric composite scaffold. (2011)
  • Author(s): Kana Sakai, Yoshiyuki Arima,Kenichirou Yasui, Tomoko Kojima, Fumito Sakamoto, Yoshiya Hashimoto, Shunsuke Baba and Naoyuki Matsumoto.
  • Journal Title: J Osaka Dent Univ Volume: 45(2) Pages: 151-157
  • NAID: 110008761437
  • Peer Reviewed
• [Journal Article] Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphateparticles. (2011)
  • Author(s): Kana Sakai, Yoshiya Hashimoto,Shunsuke Baba, Aki Nishiura, Naoyuki Matsumoto.
  • Journal Title: Dent Mater J Volume: 30(6) Pages: 913-922
  • Peer Reviewed
• [Journal Article] Evaluation of a 3-D, woven-fabric, composite scaffold using experimen tal canine models of bone defects inmandibles (2011)
  • Author(s): Shunsuke Baba, Yoshiya Hashimoto, Takeomi Inoue, Daisuke Kimura, Saeko S umikura, Yumi Sonoda Yoichi Yamada, Kenji Ito, Masaki Hojo, Taiji Adach i.
  • Journal Title: J Oral Tissue Engin Volume: 8(3) Pages: 212-221
  • Peer Reviewed
• [Journal Article] Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles (2011)
  • Author(s): 坂井加奈
  • Journal Title: Dental Materials Journal Volume: 30 Issue: 6 Pages: 913-922
  • DOI: 10.4012/dmj.2011-126
  • NAID: 10030026782
  • ISSN: 0287-4547, 1881-1361
  • Peer Reviewed
• [Journal Article] Bone regeneration efficacy of bone marrow-derived mesenchymal stem cells in a 3-D woven fabric composite scaffold (2011)
  • Author(s): 坂井加奈
  • Journal Title: J Osaka Dent Univ Volume: 45 Pages: 151-157
  • Peer Reviewed
• [Journal Article] Evaluation of a 3-D woven-fabric composite scaffold using experimental canine models of bone defects in mandibles (2011)
  • Author(s): 馬場俊輔
  • Journal Title: J Oral Tissue Engin Volume: 8 Pages: 212-221
  • NAID: 130004456623
  • Peer Reviewed
• [Journal Article] Efficacy of Bone Regeneration with Poly (Pro-Hyp-Gly) Synthetic Polypeptide Sponge as Scaffold Using Bone Marrow Derived Mesenchymal Stem Cells (2011)
  • Author(s): 木村大輔
  • Journal Title: J Oral Tissue Engin Volume: 8 Pages: 162-172
  • Peer Reviewed
• [Journal Article] Direct effects of estrogen on differentiation and apoptosis of osteoclasts (2011)
  • Author(s): 松本尚之
  • Journal Title: Orthodontic Waves Volume: 70 Pages: 8-14
  • NAID: 130005024638
  • Peer Reviewed
• [Journal Article] Effectiveness of scaffolds with pre-seeded mesenchymal stem cells in bone regeneration- Assessment of osteogenic ability of scaffolds implanted under the periosteum of the cranial bone of rats. (2010)
  • Author(s): Shunsuke Baba, Takeomi Inoue, YoshiyaHashimoto, Daisuke Kimura, Masatoshi Ueda, Kana Sakai, Naoyuki Matsumoto, Chiaki Hiwa, Taiji Adachi and Masaki Hojo
  • Journal Title: Dent Mater J Volume: 29(6) Pages: 673-681
  • NAID: 10026962601
  • Peer Reviewed
• [Journal Article] Adsorption of salivary-related proteins on the surface of orthodontic materials evaluated using quartz crystal microbalance (2010)
  • Author(s): 松本尚之
  • Journal Title: Nano Biomedicine Volume: 2 Pages: 1-9
  • NAID: 130004960243
  • Peer Reviewed
• [Journal Article] Effectiveness of scaffolds with pre-seeded mesenchymal stem cells in bone regeneration-Assessment of osteogenic ability of scaffolds implanted under the periosteum of the cranial bone of rats (2010)
  • Author(s): 馬場俊輔
  • Journal Title: Dent Mater J Volume: 29 Pages: 673-681
  • NAID: 10026962601
  • Peer Reviewed
• [Journal Article] Effect of long acting nitric oxide donors on the differentiation of osteoclasts derived from mouse bone marrow macrophages (2010)
  • Author(s): 松本尚之
  • Journal Title: Journal of Osaka Dental University Volume: 44 Pages: 133-138
  • Peer Reviewed
• [Journal Article] Development of titanium quartz crystal microbalance sensor by magnetron sputtering (2010)
  • Author(s): 松本尚之
  • Journal Title: J Oral Tissue Engin Volume: 8 Pages: 52-59
  • NAID: 130004941165
  • Peer Reviewed
• [Presentation] レーザーアブレーション法を用いたアパタイトコーティングポリ乳酸足場の可能性 (2012)
  • Author(s): 安井憲一郎,松本尚之,橋本典也,馬場俊輔,有馬良幸,坂本章人,本津茂樹
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2012-11-10
• [Presentation] 骨補填材料としてのPoly(PHG)アパタイト複合体の有用性 (2012)
  • Author(s): 有馬良幸,安井憲一郎,坂本章人,上村直也,橋本典也,馬場俊輔,松本尚之
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪市
  • Year and Date: 2012-11-10
• [Presentation] ラット頭蓋骨欠損におけるアパタイトコーティングポリ乳酸足場の骨再生の評価 (2012)
  • Author(s): 安井憲一郎,橋本典也,馬場俊輔,本津茂樹,松本尚之
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2012-09-28
• [Presentation] ポーラスα-リン酸三カルシウム/アテロコラーゲンスポンジ複合体のラット頭蓋冠骨欠損での骨再性能の評価 (2012)
  • Author(s): 有馬良幸,上村直也,橋本典也,松本尚之
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2012-09-28
• [Presentation] Evaluation of bone regeneration of Poly-l-lactide scaffold coating thin calcium phosphate by 3D image construction (2012)
  • Author(s): Kenichirou Yasui, Yoshiyuki Arima,Shigeki Hontsu, Yoshiya Hashimoto, Shunsuke Baba, Naoyuki Matsumoto
  • Organizer: 100th FDI Annual WorldDental Congress
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2012-08-29
• [Presentation] Evaluation of boneformation of combining α -TCP andatelocollagen by 3D image construction (2012)
  • Author(s): Yoshiyuki Arima, Kenichirou Yasui,Fumito Sakamoto, Naoya Uemura, Yoshiya Hashimoto, Shunsuke Baba, Naoyuki Matsumoto
  • Organizer: 100th FDI Annual WorldDental Congress
  • Place of Presentation: HongKong, China
  • Year and Date: 2012-08-29
• [Presentation] コラーゲン様ペプチド/αTCP骨補填材による骨再生の三次元構造解析 (2011)
  • Author(s): 松本尚之
  • Organizer: 第70回日本矯正歯科学会大会&第4回国際会議プログラム・抄録集2011:252
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-18
• [Presentation] コラーゲン様ポリペプチド/トリリン酸カルシウム骨補填材の骨形成能のマイクロフォーカスX線CTによる評価 (2011)
  • Author(s): 松本尚之
  • Organizer: 第9回日本再生歯科医学会学術大会・総会抄録集
  • Place of Presentation: 大阪
  • Year and Date: 2011-09-10
• [Presentation] Nanoparticle-Assemble Approach Toward Fabrication of Transparent Hydroxyapatite with Low Crystallinity (2011)
  • Author(s): 松本尚之
  • Organizer: Joint conference of 5^<th> international conference on sciemce and technology for advanced ceramics(STAC5)and 2^<nd> international materials (AMDI2) program
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-23
• [Presentation] Effects on Bone Regeneration When Collagen Model Polypeptides Are Combined with Various Sized Alpha-tricalcium Phosphate Particles (2011)
  • Author(s): Kana Sakai, Yoshiya Hashimoto,Shunsuke Baba, Aki Nishiura, Naoyuki Matsumoto
  • Organizer: The international dental materialscongress
  • Place of Presentation: Soul,Korea.6
  • Year and Date: 2011-05-28
• [Presentation] Effects on Bone Regeneration When Collagen Model Polypeptides AreCombined with Various Sized AlPharticalcium Phosphate Particles (2011)
  • Author(s): 松本尚之
  • Organizer: Proceeding of the inter national dental material congress 2011
  • Place of Presentation: Seoul Korea
  • Year and Date: 2011-05-28
• [Presentation] PRPおよびPPPと骨髄間葉系幹細胞を組み合わせた骨再生能の評価 (2010)
  • Author(s): 松本尚之
  • Organizer: 第69回日本矯正歯科学会
  • Place of Presentation: 神奈川
  • Year and Date: 2010-09-27
• [Presentation] ポリL乳酸三次元織物構造体スキャホールドと骨髄間葉系幹細胞を組み合わせた歯槽骨再生方法の可能性 (2010)
  • Author(s): 松本尚之
  • Organizer: 第25回日本歯科産業学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-07-25
• [Presentation] Fabrication of poly-L-lactide scaffold coating thin calcium phosphate (2010)
  • Author(s): Naoyuki Matsumoto, Kenichirou Yasui,Yoshiyuki Arima, Shigeki Hontsu, Yoshiya Hashimoto, Shunsuke Baba
  • Organizer: 90th General Session &Exhibition of the IADR.
  • Place of Presentation: Iguacu Falls, Brazil
  • Year and Date: 2010-06-21
• [Presentation] QCMによる歯科矯正用材料表面に対する唾液関連タンパク質の吸着挙動の解析 (2010)
  • Author(s): 松本尚之
  • Organizer: 第524回大阪歯科学会
  • Place of Presentation: 大阪
  • Year and Date: 2010-06-12
• [Presentation] QCMナノセンサよる唾液関連タンパク質と歯科材料の吸着挙動 (2010)
  • Author(s): 松本尚之
  • Organizer: 第55回日本歯科理工学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-17
• [Presentation] Effectiveness of 3D woven fabric composite scaffold in bone regeneration (2010)
  • Author(s): 松本尚之
  • Organizer: 88 th General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona
• [Presentation] レーザーアブレーション法を用いたアパタイトコーティングポリ乳酸足場の可能性
  • Author(s): 安井憲一郎
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪府：インテックス大阪 2号館
• [Presentation] 骨補填材料としてのPoly(PHG)アパタイト複合体の有用性
  • Author(s): 有馬良幸
  • Organizer: 第22回日本歯科医学会総会
  • Place of Presentation: 大阪府：インテックス大阪 2号館
• [Presentation] ラット頭蓋骨欠損におけるアパタイトコーティングポリ乳酸足場の骨再生の評価
  • Author(s): 安井憲一郎
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 岩手県：マリオス、アイーナ、アイスアリーナ
• [Presentation] ポーラスα-リン酸三カルシウム/アテロコラーゲンスポンジ複合体のラット頭蓋冠骨欠損での骨再性能の評価
  • Author(s): 有馬良幸
  • Organizer: 第71回日本矯正歯科学会大会
  • Place of Presentation: 岩手県：マリオス、アイーナ、アイスアリーナ
• [Presentation] Evaluation of bone regeneration of Poly-l-lactide scaffold coating thin calcium phosphate by 3D image construction
  • Author(s): Kenichirou Yasui
  • Organizer: 100th FDI Annual World Dental Congress
  • Place of Presentation: China: Hong Kong Convention and Exhibition Centre
• [Presentation] Evaluation of bone formation of combining α-TCP and atelocollagen by 3D image construction
  • Author(s): Yoshiyuki Arima
  • Organizer: 100th FDI Annual World Dental Congress
  • Place of Presentation: China: Hong Kong Convention and Exhibition Centre
• [Presentation] Fabrication of poly-L-lactide scaffold coating thin calcium phosphate
  • Author(s): Naoyuki Matsumoto
  • Organizer: 90th General Session & Exhibition of the IADR
  • Place of Presentation: Brazil: Iguacu Falls