Analysis of Genome Methylation Profile in Relation to Common Mechanisms of Periodontitis and Rhematoid Arthritis Onset
Project/Area Number |
22592309
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Periodontal dentistry
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Research Institution | Niigata University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOMATSU Yasutaka 新潟大学, 医歯学総合病院, 助教 (40422597)
|
Project Period (FY) |
2010-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 歯周炎 / リウマチ / インターロイキン6 / ゲノム / メチル化 / サイトカイン / 遺伝子 / タンパク質 / インターロイキン6 |
Research Abstract |
The aim of the present study is to elucidate the role of methylation status of interleukin-6 (IL-6) gene in regulation of signal expression in relation to susceptibility to periodontitis and rheumatoid arthritis (RA), because of the similarities in the pathologic features of these diseases. The results indicated that patients with periodontitis and RA showed the hypomethylated status of IL-6 gene and increased IL-6 levels than healthy control individuals. These results suggest that IL-6 gene methylation may play a role in the pathogenesis of periodontitis and RA.
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Report
(5 results)
Research Products
(55 results)
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[Journal Article] Amino acid profiles in relation to chronic periodontitis and rheumatoid arthritis2014
Author(s)
Kobayashi T, Okada M, Ito S, Kobayashi D, Shinhara A, Muramatsu T, Kobayashi T, Narita I, Nakazono K, Murasawa A, Yoshie H
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Journal Title
Open Journal of Stomatology
Volume: 4(2)
Pages: 49-55
Related Report
Peer Reviewed
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