| Project/Area Number |
22592312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
TANIMOTO Ichiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00280686)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masami 岡山大学, 岡山大学病院, 准教授 (70444677)
NARUISHI Koji 岩手医科大学, 歯学部, 歯学部 (00346446)
MINESHIBA Junji 岡山大学, 岡山大学, 講師 (00509383)
OMORI Kazuhiro 岡山大学, 大学院・医歯薬学総合研究科, 助教 (20549860)
TAKASHIBA Syogo 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50226768)
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|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 歯周炎 / 慢性炎症 / 癌転移 / 歯周病 / 慢性感染 / がん転移 |
|---|
| Research Abstract |
In the present study, we demonstrated the opposite association between localized and systemic inflammatory responses. Our finding suggests that appropriate infectious exposure might be needed to maintain our life. Taken together, a severe sepsis-like condition elicited by bacteremia, is likely responsible for the mortality associated with P. gingivalisinfection, but immune system would regulate the unwanted systemic responses. These systemic responses may alsoimpact metastatic cancer.
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