| Project/Area Number |
22592314
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
|
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGATA Toshihiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (10127847)
INAGAKI Yuuji 徳島大学, 病院, 助教 (50380019)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 糖尿病 / 歯周炎 / 歯肉溝滲出液 / 骨代謝マーカー / オステオポンチン |
|---|
| Research Abstract |
In the experiments of rat diabetic periodontitis model, histochemical investigation revealed that osteopontin was greatly localized in the portion of periodontal inflammatory sites, suggesting that osteopontin might be involved in the progression of severe periodontitis. The assay of gingival crevicular fluid from periodontitis patients revealed that osteopontin was not clearly detected but type-1 collagen peptide: ICTP) was detected in patients with severe periodontitis.
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