| Project/Area Number |
22592316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAMURA Takahisa 熊本大学, 生命科学研究部, 准教授 (20176499)
IRIE Atusi 熊本大学, 生命科学研究部, 講師 (30250343)
SHINOHARA Masanori 熊本大学, 生命科学研究部, 教授 (90117127)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 成人型歯周病 / Porphyromonas gingivalis / システインプロテアーゼ / ジンジパイン / 白血球細胞表面タンパク / RI 標識 / プロテオミクス / 予防および治療法開発 / RI標識 |
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| Research Abstract |
The gingipains of the cystein protease which Porphyromonasgingivalis which is leading cause bacteria of adult type periodontosis emits aims at themechanism elucidation which serves as immune tolerance by cutting of the cell surfacemolecule in connection with a white corpuscle function. Full use of the technique of thesign according the functional protein on a white corpuscle cell membrane to radioisotopeand proteomics was made, influence on periodontosis was investigated, and the preventionmethod and cure development of periodontosis were aimed at. Although technique andconditions are improved per RI sign and gingipains processing and it is under continuation,continuous research is due not to result in identification of specific protein but tocontinue be done.
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