The effects of passive immunization therapy on supportive periodontal therapy

• Project/Area Number: 22592318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Nihon University
• Principal Investigator: SUGANO Naoyuki 日本大学, 歯学部, 准教授 (30246904)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 受動免疫 / プラークコントロール / 歯周病 / ワクチン療法 / メインテナンス治療

Research Abstract

Passive immunization using egg yolk antibody against periodontal pathogens(Gingipains)may be an effective way for the treatment of periodontitis.This study showed the possible effects of the biological oral flora control on periodontal maintenance therapy.

Research Products

• [Journal Article] Biological plaque control: novel therapeutic approach to periodontal disease (2012)
  • Author(s): Sugano N
  • Journal Title: J Oral Sci Volume: 54 Pages: 1-5
  • NAID: 130002070008
  • Peer Reviewed
• [Journal Article] Hepatocytes produce tumor necrosis factor-α and interleukin-6 in response to Porphyromonas gingivalis. (2012)
  • Author(s): Takano M, Sugano N, Mochizuki S, Koshi RN, Narukawa TS, Sawamoto Y, Ito K.
  • Journal Title: J Periodontal Res Volume: 47 Pages: 89-94
  • Peer Reviewed
• [Journal Article] Relationship between salivary antioxidant capacity and phases of the menstrual cycle. (2012)
  • Author(s): Kawamoto A, Sugano N, Motohashi M, Matsumoto S, Ito K.
  • Journal Title: J Periodontal Res Volume: 47 Pages: 593-598
  • Peer Reviewed
• [Journal Article] Biological plaque control: novel therapeutic approach to periodontal disease. (2012)
  • Author(s): sugano n
  • Journal Title: Journal of oral science Volume: 54 Pages: 1-5
  • NAID: 130002070008
  • Peer Reviewed
• [Journal Article] Biological plaque control : novel therapeutic approach to periodontal disease (2012)
  • Author(s): Naoyuki Sugano
  • Journal Title: Journal of Oral Science Volume: 54 Pages: 1-5
  • NAID: 130002070008
  • Peer Reviewed
• [Journal Article] Impact of minocycline ointment for periodontal treatment of oral bacteria. (2011)
  • Author(s): Nakao R, Takigawa S, Sugano N, Koshi R, Ito K, Watanabe H, Senpuku H.
  • Journal Title: Jpn J Infect Dis Volume: 64 Pages: 156-160
  • NAID: 40018775777
  • Peer Reviewed
• [Journal Article] Relationship between Oral Malodor and the Menstrual Cycle. (2010)
  • Author(s): Kawamoto A, Sugano N, Motohashi M, Matsumoto S, Ito K.
  • Journal Title: J Periodontal Res Volume: 45 Pages: 681-687
  • Peer Reviewed
• [Journal Article] The effect of systemic anti-tumor necrosis factor-alpha treatment on Porphyromonas gingivalis infection in type 2 diabetic mice. (2010)
  • Author(s): Takano M, Nishihara R, Sugano N, Matsumoto K, Yamada Y, Takane M, Fujisaki Y, Ito K.
  • Journal Title: Arch. Oral Bio Volume: 55 Pages: 379-384
  • Peer Reviewed
• [Journal Article] Salivary microbial levels in relation to periodontal status and caries development. (2010)
  • Author(s): Iwano Y, Sugano N, Matsumoto K, Nishihara R, Iizuka T, Yoshinuma N, Ito K.
  • Journal Title: J Periodontal Res Volume: 45 Pages: 165-169
  • Peer Reviewed