| Project/Area Number |
22592319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Nihon University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Hideki 日本大学, 歯学部, 助教 (30453898)
中尾 寿美 日本大学, 松戸歯学部, 助手 (20102577)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 転写調節 / 転写因子 / 骨芽細胞 / 石灰化 / 細胞外マトリックス / 歯周組織再生 / 骨シアロタンパク質 / 発現調節 / 遺伝子プロモーター |
|---|
| Research Abstract |
Protamine induced BSP transcription by targeting CRE, FRE and HOX sites in the proximal promoter of the rat BSP gene. Moreover, phospho-CREB, c-Fos, c-Jun, JunD, Fra2, Dlx5, Msx2, Runx2 and Smadl transcription factors appear to be key regulators of protamine effects on BSP transcription.
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