Mechanism of transcriptional regulation of extracellular matrix and transcription factors which control periodontal regeneration.
| Project/Area Number |
22592319
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKAI Hideki 日本大学, 歯学部, 助教 (30453898)
中尾 寿美 日本大学, 松戸歯学部, 助手 (20102577)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 転写調節 / 転写因子 / 骨芽細胞 / 石灰化 / 細胞外マトリックス / 歯周組織再生 / 骨シアロタンパク質 / 発現調節 / 遺伝子プロモーター |
|---|
| Research Abstract |
Protamine induced BSP transcription by targeting CRE, FRE and HOX sites in the proximal promoter of the rat BSP gene. Moreover, phospho-CREB, c-Fos, c-Jun, JunD, Fra2, Dlx5, Msx2, Runx2 and Smadl transcription factors appear to be key regulators of protamine effects on BSP transcription.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Aggregatibacter actinomycetemcomitans lipopolysaccharide regulates bone sialoprotein gene transcription.2012
Author(s)
Li X, Zhou L, Takai H, Sasaki Y, Mezawa M, Li Z, Wang Z, Yang L, Wang S, Matsumura H, Kaneko T, Yoshimura A, Ogata Y.
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Journal Title
J Cell Biochem
Volume: 113
Issue: 9
Pages: 2822-2834
DOI
Related Report
Peer Reviewed
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