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Elucidation of mechanism of drug-induced gingival overgrowth and search for its therapeutic drugs

Research Project

Project/Area Number 22592321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Periodontal dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

HATTORI Toshimi  松本歯科大学, 歯学部, 准教授 (70064706)

Co-Investigator(Kenkyū-buntansha) ARA Toshiaki  松本歯科大学, 歯学部, 助教 (90387423)
Research Collaborator KAWAKAMI Toshiyuki  松本歯科大学, 総合歯科医学研究所, 教授 (80104892)
NAKANO Keisuke  松本歯科大学, 総合歯科医学研究所, 准教授 (10325095)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords歯肉増殖症 / ニフェジピン / フェニトイン / カルシウム感知受容体 / TRPV1 チ ャネル / 細胞内カルシウム濃度 / TRPV1チャネル / 細胞内カルシウム / CaSR / TRPチャネル
Research Abstract

It was elucidated the mechanism of gingival overgrowth as described below. Nifedipine (an anti-hypertension drug) and phenytoin (an antiepileptic drug) directly act on calcium-sensing receptors, which elevate the intracellular Ca2+ concentration ([Ca2+]i) by enhancing the Ca2+ release from intracellular Ca2+ stores and Ca2+ entry through transient receptor potential V1 channels. The [Ca2+]i elevation becomes a trigger of evocation of gingival overgrowth (Modified Ca2+ trigger theory).

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (11 results)

  • [Journal Article] Phenytoin-induced elevation of the intracellular calcium concentration by stimulation of calcium-sensing receptors in gingival fibroblasts.2013

    • Author(s)
      Hattori T, Nakano K, Kawakami T.
    • Journal Title

      Pharmacol Pharmac.

      Volume: 4

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phenytoin-induced elevation of the intracellular calcium concentration by stimulation of calcium-sensing receptors in gingival fibroblasts2013

    • Author(s)
      Hattori T.
    • Journal Title

      Pharmacol Pharmac

      Volume: 4

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological evidence for the involvement of calcium entry through TRPV1 channels in nifedipine-induced [Ca2+]i elevation in gingival fibroblasts.2012

    • Author(s)
      Hattori T, Ara T, Fujinami Y.
    • Journal Title

      Pharmacol Pharmac

      Volume: 3 Pages: 427-432

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological evidence for the involvement of calcium entry through TRPV1 channels in nifedipine-induced [Ca2+]i elevation in gingival fibroblasts2012

    • Author(s)
      Hattori T.
    • Journal Title

      Pharmacol Pharmac

      Volume: 3 Pages: 427-432

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological evidences for the stimulation of calcium-sensing receptors by nifedipine in gingival fibroblasts.2011

    • Author(s)
      Hattori T, Ara T, Fujinami Y.
    • Journal Title

      J Pharmacol Pharmacother

      Volume: 2 Issue: 1 Pages: 30-35

    • DOI

      10.4103/0976-500x.77111

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological evidences for the stimulation of calcium-sensing receptors by nifedipine in gingival fibroblasts2011

    • Author(s)
      Hattori T, Ara T, Fujinami Y
    • Journal Title

      Journal of Pharmacology and Pharmacotherapeutics

      Volume: 2 Pages: 30-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 歯肉線維芽細胞における TRPV1 チャネルに対するフェニトインの 作用2013

    • Author(s)
      服部敏己、川上敏行.
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯肉線維 芽細胞におけるフェニトインとカルシウム感知 受容体との関係.2012

    • Author(s)
      服部敏己、中野敬介、川上敏行.
    • Organizer
      第54回歯科基礎医学会学 術大会ならびに総会.
    • Place of Presentation
      郡山
    • Year and Date
      2012-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Pharmacological evidences for involvement of calcium entry through TRPV1 channels in nifedipine-induced gingival overgrowth.2012

    • Author(s)
      Hatto
    • Organizer
      7th Conference of the European Federation ofPeriodontology.
    • Place of Presentation
      ウィーン(オーストリア
    • Year and Date
      2012-06-06
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯肉線維芽細胞におけるフェニトインによる細胞内カルシウム濃度の上昇2012

    • Author(s)
      服部敏己、荒敏昭、藤波義明
    • Organizer
      日本薬理学会年会(第85回)
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯肉線維芽細胞におけるフェニトインによる細胞内カル シウム濃度の上昇.2012

    • Author(s)
      服部敏己、 荒 敏昭、藤波義明.
    • Organizer
      第85回日本薬理学会年 会.
    • Place of Presentation
      京都.
    • Year and Date
      2012-03-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯肉線維芽細胞におけるニフェジピンとTRPV1チャネルとの関係2011

    • Author(s)
      服部敏己、荒敏昭
    • Organizer
      歯科基礎医学会学術大会ならびに総会(第53回)
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯肉線維芽細胞にお けるニフェジピンとTRPV1チャネルとの関係.2011

    • Author(s)
      服部 敏己、荒 敏昭
    • Organizer
      第53回歯科基礎医学会学術大会ならびに総 会
    • Place of Presentation
      岐阜.
    • Year and Date
      2011-09-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯肉線維芽細胞における TRP チャネルに対するニフ ェジピンの作用.2011

    • Author(s)
      服部 敏己、 荒 敏昭藤波 義明.
    • Organizer
      第84回日本薬理学会年会.
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Pharmacological evidences for involvement of calcium entry through TRPV1 channels in nifedipine-induced gingival overgrowth

    • Author(s)
      Hattori T.
    • Organizer
      7th Conference of the European Federation of Periodontology
    • Place of Presentation
      ウィーン(オーストリア)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯肉線維芽細胞におけるフェニトインとカルシウム感知受容体との関係

    • Author(s)
      服部 敏己
    • Organizer
      第54回歯科基礎医学会学術大会ならびに総会
    • Place of Presentation
      奥羽大学(郡山)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯肉線維芽細胞におけるTRPV1チャネルに対するフェニトインの作用

    • Author(s)
      服部 敏己
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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