| Project/Area Number |
22592321
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Periodontal dentistry
|
|---|
| Research Institution | Matsumoto Dental University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ARA Toshiaki 松本歯科大学, 歯学部, 助教 (90387423)
|
|---|
| Research Collaborator |
KAWAKAMI Toshiyuki 松本歯科大学, 総合歯科医学研究所, 教授 (80104892)
NAKANO Keisuke 松本歯科大学, 総合歯科医学研究所, 准教授 (10325095)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 歯肉増殖症 / ニフェジピン / フェニトイン / カルシウム感知受容体 / TRPV1 チ ャネル / 細胞内カルシウム濃度 / TRPV1チャネル / 細胞内カルシウム / CaSR / TRPチャネル |
|---|
| Research Abstract |
It was elucidated the mechanism of gingival overgrowth as described below. Nifedipine (an anti-hypertension drug) and phenytoin (an antiepileptic drug) directly act on calcium-sensing receptors, which elevate the intracellular Ca2+ concentration ([Ca2+]i) by enhancing the Ca2+ release from intracellular Ca2+ stores and Ca2+ entry through transient receptor potential V1 channels. The [Ca2+]i elevation becomes a trigger of evocation of gingival overgrowth (Modified Ca2+ trigger theory).
|
