| Project/Area Number |
22592322
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Aichi Gakuin University |
|---|
Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
NARUSE Keiko 愛知学院大学, 歯学部, 准教授 (30387576)
KOBAYASHI Yasuko 愛知学院大学, 歯学部, 講師 (40418926)
NOGUCHI Toshihide 愛知学院大学, 歯学部, 教授 (50014262)
KIKUCHI Takeshi 愛知学院大学, 歯学部, 講師 (40421242)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | メタボリックシンドローム / 歯周病 / 歯周病学 / 動脈硬化 / 炎症 |
|---|
| Research Abstract |
To investigate a direct involvement of periodontal disease on metabolic syndrome, we developed ligature-induced periodontitis in rats. Serum triglyceride was significantly higher in periodontitis rats compared with normal rats. The mRNA expressions of TNF- α and monocyte adhesion to endothelial cells were significantly increased in aorta of periodontitis rats.
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