| Project/Area Number |
22592323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
DOMAE Naochika 大阪歯科大学, 歯学部, 名誉教授 (60115889)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Masatoshi 大阪歯科大学, 歯学部, 名誉教授 (00067117)
KAMBARA Masaki 大阪歯科大学, 歯学部, 教授 (90103085)
NAGANO Yutaka 大阪歯科大学, 歯学部, 講師(非常勤) (80228048)
MIYAMAE Masami 大阪歯科大学, 歯学部, 講師 (20298821)
MIYAKE Tatsuro 大阪歯科大学, 歯学部, 准教授 (40200141)
SAWAI Hirofumi 大阪歯科大学, 歯学部, 講師 (40298823)
GODA Seiji 大阪歯科大学, 歯学部, 講師 (70351476)
ARISHIRO Kumiko 大阪歯科大学, 歯学部, 講師(非常勤) (20460769)
NOTOHARA Yasuhiro 大阪歯科大学, 歯学部, 講師(非常勤) (10548324)
KANEDA Kazuhiro 大阪歯科大学, 歯学部, 講師(非常勤) (90533886)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 歯周病 / 動脈硬化症 / 虚血性心疾患 / 11β-HSD1 / 動脈硬化 |
|---|
| Research Abstract |
We clinically and etiologically investigated the bidirectional causality between atherosclerotic lesion in lifestyle-related disease and periodontal disease. Intracardiac calcification severity was positively correlated with the degrees of periodontal disease. Moreover, a statistically significant increase of 11β-HSD1 mRNA expression was detected in the periodontal disease group compared with the controls. Furthermore, the depth of periodontal pockets significantly correlated with the increased expression of 11β-HSD1 mRNA. These results suggest that the increased expression of11β-HSD1 may play a role in the bidirectional causality between atherosclerotic lesion and periodontal disease.
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