| Project/Area Number |
22592334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
KAWAHARA Kazuko 広島大学, 大学院・医歯薬保健学研究院, 助教 (20034209)
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| Co-Investigator(Kenkyū-buntansha) |
NIKAWA Hiroki 広島大学, 大学院・医歯薬保健学研究院, 教授 (10228140)
MAKIHIRA Seichou 広島大学, 大学院・医歯薬学総合研究科, 准教授 (80304450)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 咀嚼 / 肥満 / 糖尿病 / BDNF / 唾液腺 / DNA チップ / 肥満・糖尿病 / メタボリック / 生活習慣病 / TSODマウス / 糖代謝 / 脂質代謝 / DNAチップ / 咀嚼誘導 / ラット / 肥満マウス / 飲水量 / 多飲性 / 糖尿 / 脳由来神経栄養因子 / 無味ガム / ELISA法 / ビーズ法 |
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| Research Abstract |
DNA microarray analyses were performed to examine a possibility whether difference in the habitual-chewing-load would affect expression of genes that linked to the glucose and lipid metabolism using mice.In a comparison between groups of pellet feeding and powdery feeding, of which components were the same, parotid gland from the obese diabetes mice showed significant difference in the mRNA level in 35% of 194 genes installed to the chip, and ones from the normal mice about 60%. Each genes which showed a significantly different transcription level between the feeding groups, signals of pellet feeding group were higher than ones of powder feeding group.
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