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Study on control effect of the lifestyle-related disease through the BDNF factor by the chewing stimulation

Research Project

Project/Area Number 22592334
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionHiroshima University

Principal Investigator

KAWAHARA Kazuko  広島大学, 大学院・医歯薬保健学研究院, 助教 (20034209)

Co-Investigator(Kenkyū-buntansha) NIKAWA Hiroki  広島大学, 大学院・医歯薬保健学研究院, 教授 (10228140)
MAKIHIRA Seichou  広島大学, 大学院・医歯薬学総合研究科, 准教授 (80304450)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords咀嚼 / 肥満 / 糖尿病 / BDNF / 唾液腺 / DNA チップ / 肥満・糖尿病 / メタボリック / 生活習慣病 / TSODマウス / 糖代謝 / 脂質代謝 / DNAチップ / 咀嚼誘導 / ラット / 肥満マウス / 飲水量 / 多飲性 / 糖尿 / 脳由来神経栄養因子 / 無味ガム / ELISA法 / ビーズ法
Research Abstract

DNA microarray analyses were performed to examine a possibility whether difference in the habitual-chewing-load would affect expression of genes that linked to the glucose and lipid metabolism using mice.In a comparison between groups of pellet feeding and powdery feeding, of which components were the same, parotid gland from the obese diabetes mice showed significant difference in the mRNA level in 35% of 194 genes installed to the chip, and ones from the normal mice about 60%. Each genes which showed a significantly different transcription level between the feeding groups, signals of pellet feeding group were higher than ones of powder feeding group.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2013 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (11 results)

  • [Journal Article] Characteristics of HighMolecular Weight Hyaluronic Acid as aBDNF Scaffold in Periodontal TissueRegeneration2011

    • Author(s)
      Takeda K, Sakai N, Shiba H,他 1中 9 th,Kawahara, K
    • Journal Title

      Tissue Eng PartA

      Volume: 17(7-8) Pages: 955-67

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bovine milk fermented with Lactbacillus rhamnosus L8020 decreases the oral carriage of Streptococci mutans and burden of periodontal pathogens2011

    • Author(s)
      Nikawa, H., Tomiyama, Y., Hira-matsu M, Kawahara, K, et.al.
    • Journal Title

      Journal of Investigative and Clinical Dentistry

      Volume: 2 Issue: 3 Pages: 187-196

    • DOI

      10.1111/j.2041-1626.2011.00056.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of High Molecular Weight Hyaluronic Acid as a BDNF Scaffold in Periodontal Tissue Regeneration2011

    • Author(s)
      Takeda, K., Sakai, N., Shiba, H, Kawahara, K, et.al.
    • Journal Title

      Tissue Engineering Part A

      Volume: 17 Issue: 7-8 Pages: 955-967

    • DOI

      10.1089/ten.tea.2010.0070

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 三次元形状データを用いた歯形彫刻制作物の客観的評価-主観的評価との比較-2011

    • Author(s)
      木原琢也、下江宰司、河原和子、二川浩樹, 他
    • Journal Title

      日本歯科理工学会誌

      Volume: 30 Pages: 202-206

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 非接触式三次元形状装置を用いた紙歯型彫刻制作物の客観的評価の試み2010

    • Author(s)
      木原琢也、二川、牧平、河原, 他
    • Journal Title

      日本歯科医学教育学会雑誌

      Volume: 26 Pages: 248-252

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 異なる咀嚼負荷飼育マウスの唾液腺に対する DNA チップ解析2013

    • Author(s)
      河原和子
    • Organizer
      第55回歯科基礎医学会学術大会
    • Place of Presentation
      岡山 (発表確定)
    • Year and Date
      2013-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 広島大学歯学科4年生における基礎的食材知識について2012

    • Author(s)
      河原和子
    • Organizer
      第31回日本歯科医学教育学会総会・学術大会
    • Place of Presentation
      岡山
    • Related Report
      2012 Final Research Report
  • [Presentation] 広島大学歯学科4年生における基礎的食材知識について2012

    • Author(s)
      河原和子、仁井谷善恵、ニ川浩樹、菅井基行
    • Organizer
      第31回日本歯科医学教育学会学術大会
    • Place of Presentation
      岡山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 歯学科4年生に実施した重要食材の基礎知識に関する調査報告2012

    • Author(s)
      河原和子、仁井谷善恵、ニ川浩樹、菅井基行
    • Organizer
      第51回広島県歯科医学会
    • Place of Presentation
      広島市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳酸菌由来バクテリオシンKog1フラグメントの炎症性サイトカインの発現抑制効果の検討2012

    • Author(s)
      黒瀬めぐみ、峯裕一、田地剛、河原和子、二川浩樹
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳酸菌由来バクテリオシンKog1のフラグメントの抗口腔病原細菌作用2012

    • Author(s)
      冨山結布、黒瀬めぐみ、峯裕一、田地剛、河原和子、二川浩樹
    • Organizer
      日本バイオマテリアル学会シンポジウム2012
    • Place of Presentation
      仙台市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 乳酸菌由来のバクテリオシンはporphyromonas gingivalis LPSによるマクロファージの活性化を阻害する2011

    • Author(s)
      黒瀬めぐみ、峯裕一、冨山結布、河原和子、二川浩樹, 他
    • Organizer
      日本防菌防黴学会第38回年次大会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] The effect of bacteriocins derived from Lactbacillus rhamnosus againstoral pathogens2011

    • Author(s)
      Tomiyama Y, Hiyama A, Kurose M, Kawahara K, Nikawa H, et.al.
    • Organizer
      4th Hiroshima Conference on Education and Science in Dentistry
    • Place of Presentation
      Hiroshima
    • Related Report
      2011 Annual Research Report
  • [Presentation] 塩基性線維芽細胞増殖因子のcDNAクローニングと大腸菌での発現2011

    • Author(s)
      岡村美菜子、小原勝、牧原清超、河原和子、二川浩樹
    • Organizer
      第33回日本バイオマテリアル学会
    • Place of Presentation
      京都
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enrollment of Na+/H+ excanger 10 during RANKL-mediated osteoclastgenesis2011

    • Author(s)
      Mine Y, Makihira S, Ohara M, Kawahara K, Nikawa H
    • Organizer
      The International Workshop on Biodental Education and Reseach
    • Place of Presentation
      Hiroshima
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゾウザメゲノム情報とヒトの歯関連遺伝子のbioinfomatics解析2010

    • Author(s)
      新川美那子、二川浩樹、小原勝、牧平清超、河原和子
    • Organizer
      日本補綴歯科学会中国・四国支部・学術大会
    • Place of Presentation
      高松
    • Year and Date
      2010-08-29
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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