Role of Rho kinase and effects of its inhibitors on interaction between periodontitis and vascular endothelial dysfunction
| Project/Area Number |
22592338
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Toshiyuki 長崎大学, 医歯(薬)学総合研究科, 教授 (10170515)
FURUGEN Reiko 長崎大学, 医歯(薬)学総合研究科, 助教 (90253674)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 歯周病原細菌 / 血管内皮細胞 / NOS |
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| Research Abstract |
Human arterial vascular cells were stimulated by periodontal pathogens or their LPSs. The results of real time PCR analysis, ELISA, and western blot analysis suggested that P. gingivalis LPS were associated with the expression of Rho kinase related genes.
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Report
(4 results)
Research Products
(12 results)
