| Project/Area Number |
22592349
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Social dentistry
|
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| Research Institution | Tsurumi University (2011-2012)
The Nippon Dental University (2010) |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
SATO Tsutomu 日本歯科大学東京短期大学, 歯科衛生学 科, 教授 (60130671)
八重垣 健 日本歯科大学, 生命歯学部, 教授 (40166468)
今井 敏夫 日本歯科大学, 生命歯学部, 准教授 (90120617)
|
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
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| Keywords | 癌関連遺伝子 / 硫化水素 / 歯肉癌細胞 / アポトーシス / PHLDA1 / アポトーシス感受性 / 癌細胞 / 歯肉上皮細胞 |
|---|
| Research Abstract |
Ca9-22 cells that highly express pleckstrin homology-like domain, family A, member 1 (PHLDA1) are susceptible to H2S-induced apoptosis. PHLDA1 in oral cancer cells plays a role in apoptosis suppression, and PHLDA1 may be a marker of apoptosis susceptibility.
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