Varicella-zoster virus IE62 immunologically cross-reacts with Brain-derived nerve growth factor and causes allodynia of herpes zoster

• Project/Area Number: 22600003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: University of Toyama
• Principal Investigator: SHIRAKI Kimiyasu 富山大学, 大学院・医学薬学研究部(医学), 教授 (50135745)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ウイルス / 帯状疱疹 / 疼痛 / 水痘帯状疱疹ウイルス / 帯状疱疹後神経痛 / 前初期抗原IE62 / 脳由来神経栄養因子(BDNF) / C線維

Research Abstract

Varicella-zoster virus （VZV) immediate early protein 62 （IE62) is a major transcriptional activator and anti-IE62 monoclonal antibody among three monoclonal antibodies recognized brain-derived nerve growth factor （BDNF). BDNF causes hyperesthesia and allodynia.This antibody augmented the BDNF activity and its intrathecal injection induced allodynia in the nerve-injured mice. Histological study of the skin of mice infected cutaneously revealed that nerve ending around herpes simplex virus （HSV) lesion increased 10 times in the number of nerve endings. Keratinocytes around HSV lesion induced nerve growth factor and this may have increased the number of nerve endings. Thus the increase in the number of nerve endings indicated the increase in the number of pain spots and this may cause the pain in the skin lesions of herpes zoster

Research Products

• [Journal Article] Varicella-zoster virus keratitis with asymptomatic conjunctival viral shedding in the contralateral eye. (2013)
  • Author(s): Miyakoshi A, Takemoto M, Shiarki K, Hayashi A
  • Journal Title: Cornea Volume: in press
  • Peer Reviewed
• [Journal Article] A novel deletion in glycoprotein G forms a cluster and causes immune evasion in herpes simplex virus type 2 infection. (2013)
  • Author(s): Daikoku T, Horiba K, Kawana T, Hirano M, Shiraki K
  • Journal Title: Journal of Medical Virology Volume: in press
  • Peer Reviewed
• [Journal Article] Characterization of virus strains resistant to the herpes virus helicase-primase inhibitor ASP2151(Amenamevir) (2012)
  • Author(s): Chono K, Katsumata K, Kontani T, Shiraki K, Suzuki H
  • Journal Title: BiochemicalPharmacology Volume: 84 Issue: 4 Pages: 459-467
  • DOI: 10.1016/j.bcp.2012.05.020
  • Peer Reviewed
• [Journal Article] Contribution of spinal galectin-3 to acute herpetic allodynia in mice (2012)
  • Author(s): Takasaki I, Taniguchi K, Komatsu F, Sasaki A, Andoh T, Nojima H, Shiraki K, Hsu DK, Liu FT, Kato I, Hiraga K, Kuraishi Y
  • Journal Title: Pain Volume: 153 Issue: 3 Pages: 585-592
  • DOI: 10.1016/j.pain.2011.11.022
  • Peer Reviewed
• [Journal Article] Varicella-zoster virus keratitis with asymptomatic conjunctival viral shedding in the contralateral eye (2012)
  • Author(s): Miyakoshi A, Takemoto M, Shiraki K, Hayashi A
  • Journal Title: Case Reports in Ophthalmology Volume: 3 Issue: 3 Pages: 343-348
  • DOI: 10.1159/000343463
  • Peer Reviewed
• [Journal Article] Efficacy of ASP2151, a helicase-primase inhibitor, against thymidine kinase-deficient herpes simplex virus type 2 infection in vitro and in vivo. (2012)
  • Author(s): Himaki T, Masui Y, Chono K, Daikoku T, Takemoto M, Haixia B, Okuda T, Suzuki H, Shiraki K.
  • Journal Title: Antiviral Research. Volume: 93(2) Issue: 2 Pages: 301-304
  • DOI: 10.1016/j.antiviral.2011.11.015
  • Peer Reviewed
• [Journal Article] Neutralizing anti-gH antibody of Varicella-zoster virus modulates distribution of gH and induces gene regulation, mimicking latency (2011)
  • Author(s): Shiraki K, Daikoku T, Takemoto M, Yoshida Y, Suzuki K, Akahori Y, Okuno T, Kurosawa Y, Asano Y.
  • Journal Title: Journal of Virology Volume: 85(16) Issue: 16 Pages: 8172-8180
  • DOI: 10.1128/jvi.00435-11
  • Peer Reviewed
• [Journal Article] Glycyrrhizin renders cells resistant to apoptosis induced by human and feline immunodeficiency virus (2011)
  • Author(s): Sato H, Kageyama S, Yamamoto H,Kurokawa M, Aoki E, Shiraki K
  • Journal Title: Journal of Traditional Medicines Volume: 28 Pages: 139-148
  • NAID: 130004495575
  • Peer Reviewed
• [Journal Article] Shimizu T, Sawamura R, Kim KH, Kim KH, Lee SH, Lee YS, Kim TG, Kai H, Yoshida H, Watanabe W, Matsuno K, Shiraki K, and Kurokawa M (2011)
  • Author(s): Shimizu T, Sawamura R, Kim KH, Kim KH, Lee SH, Lee YS, Kim TG, Kai H, Yoshida H, Watanabe W, Matsuno K, Shiraki K, and Kurokawa M
  • Journal Title: Journal of Traditional Medicines Volume: 28 Pages: 115-127
  • Peer Reviewed
• [Journal Article] Efficacy of brazilian propolis against herpes simplex virus type 1 infection in mice and their modes of antiherpetic efficacies (2011)
  • Author(s): Shimizu T, Takeshita Y, Takamori Y, Kai H, Sawamura R, Yoshida H, Watanabe W, Tsutsumi A, Park YK, Yasukawa K, Matsuno K, Shiraki K, Kurokawa K
  • Journal Title: EvidenceBased Complementary and Alternative Medicine Volume: ID 976196 Issue: 1 Pages: 9-9
  • DOI: 10.1155/2011/976196
  • Peer Reviewed
• [Journal Article] Characterization of a fully human monoclonal antibody against extracellular domain of matrix protein 2 of influenza A virus (2011)
  • Author(s): Ozawa T, Jin A, Tajiri K, Takemoto M, Okuda T, Shiraki K, Kishi H, Muraguchi A
  • Journal Title: Antiviral Research Volume: 91 Issue: 3 Pages: 283-287
  • DOI: 10.1016/j.antiviral.2011.06.012
  • Peer Reviewed
• [Journal Article] Topical creambased oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice (2011)
  • Author(s): Lipipun V, Sasivimolphan P, Yoshida Y, Daikoku T, Sritularak B, Ritthidej G, Likhitwitayawuid K, Pramyothin P, Hattori M, Shiraki K
  • Journal Title: Antiviral Research Volume: 91 Issue: 2 Pages: 154-160
  • DOI: 10.1016/j.antiviral.2011.05.013
  • Peer Reviewed
• [Journal Article] Polyphenols including catechin from green tea with in vitro antiviral activity exhibited anti-herpes simplex virus activity but not anti-influenza activity in mice (2011)
  • Author(s): Daikoku T, Horiba K, Miyata K, Takemoto M, Okuda T, Yoshida Y, Sawamura R, Nagaura Y, Kurokawa M, Shiraki K
  • Journal Title: Journal of Traditional Medicines Volume: 28 Pages: 63-72
  • Peer Reviewed
• [Journal Article] Polyphenols including catechin from green tea with in vitro antiviral activity exhibited anti-herpes simplex virus activity but not anti-influenza activity in mice (2011)
  • Author(s): Daikoku T, Horiba K, Miyata K., Takemoto M, Okuda T, Yoshida Y, Sawamura R, Nagaura Y, Kurokawa M, Shiraki K
  • Journal Title: Journal of Traditional Medicines Volume: 28(2) Pages: 63-72
  • Peer Reviewed
• [Journal Article] Topical cream-based oxyresveratrol in the treatment of cutaneous HSV-1 infection in mice (2011)
  • Author(s): Lipipun V, Sasivimolphan P, Yoshida Y, Daikoku T, Sritularak B, Ritthidej G, Likhitwitayawuid K, Pramyothin P, Hattori M, Shiraki K
  • Journal Title: Antiviral Research Volume: 91(2) Pages: 154-160
  • Peer Reviewed
• [Journal Article] Characterization of a fully human monoclonal antibody against extra cellular domain of matrix protein 2 of influenza A virus (2011)
  • Author(s): Ozawa T, Jin A, Tajiri K, Takemoto M, Okuda T, Shiraki K, Kishi H, Muraguchi A
  • Journal Title: Antiviral Research Volume: 91(3) Pages: 283-287
  • Peer Reviewed
• [Journal Article] Efficacy of Brazilian Propolis against Herpes Simplex Virus Type 1 Infection in Mice and Their Modes of Anti herpetic Efficacies (2011)
  • Author(s): Shimizu T, Takeshita Y, Takamori Y, Kai H, Sawamura R, Yoshida H, Watanabe W, Tsutsumi A, Park YK, Yasukawa K, Matsuno K, Shiraki K, Kurokawa K
  • Journal Title: Evidence-Based Complementary and Alternative Medicine Volume: ID976196 Pages: 9-9
  • Peer Reviewed
• [Journal Article] Efficacy of Korean traditional medicines against influenza virus infection in mice and their modes of anti-influenza virusaction (2011)
  • Author(s): Shimizu T, Sawamura R, Kim KH, Kim KH, Lee SH, Lee YS, Kim TG, Kai H, Yoshida H, Watanabe W, Matsuno K, Shiraki K, Kurokawa M
  • Journal Title: Journal of Traditional Medicines Volume: 28 Pages: 115-127
  • Peer Reviewed
• [Journal Article] Design and synthesis of isonucleosides constructed on a 2-Oxa-6-thiabicyclo [3.2.0] heptane scaffold (2010)
  • Author(s): oshimura Y, Asami K, Imamichi T, Okuda T, Shiraki K, Takahata H
  • Journal Title: Journal ofOrganic Chemistry Volume: 75 Issue: 12 Pages: 4161-4171
  • DOI: 10.1021/jo100556u
  • Peer Reviewed
• [Journal Article] Novel anti-cytomegalovirus activity of immunosuppressant mizoribine and its synergism with ganciclovir. (2010)
  • Author(s): Kuramoto T, Daikoku T, Yoshida Y, Takemoto M, Oshima K, Eizuru Y, Kanda Y, Shiraki K.
  • Journal Title: The Journal of Pharmacology and Experimental Therapeutics. Volume: 333(3) Issue: 3 Pages: 816-821
  • DOI: 10.1124/jpet.109.160630
  • Peer Reviewed
• [Journal Article] Widespread circulation of echovirus type 13 demonstrated by increased seroprevalence in Toyama, Japan, between 2000 and 2003. (2010)
  • Author(s): Iwai M, Yoshida H, Obara M, Horimoto E, Nakamura K, Takizawa T, Kurata T, Mizuguchi M, Daikoku T, Shiraki K.
  • Journal Title: Clinical Vaccine Immunology Volume: 17(5) Issue: 5 Pages: 764-770
  • DOI: 10.1128/cvi.00239-09
  • Peer Reviewed
• [Journal Article] Widespread circulation of echovirus type 13 demonstrated by increasedseroprevalence in Toyama, Japan between 2000 and 2003 (2010)
  • Author(s): Iwai M, Yoshida H, Obara M, Horimoto E, Nakamura K, Takizawa T, Kurata T, Mizuguchi M, Daikoku T, Shiraki K.
  • Journal Title: Clin Vaccine Immunol Volume: 17 Pages: 764-770
  • Peer Reviewed
• [Journal Article] Novel anti-cytomegalovirus activity of immunosuppressant mizoribine and its synergism with ganciclovir (2010)
  • Author(s): Kuramoto T, Daikoku T, Yoshida Y, Takemoto M, Oshima K, Eizuru Y, Kanda Y, Shiraki K.
  • Journal Title: J pharmacol Exp Ther Volume: 333 Pages: 816-821
  • Peer Reviewed
• [Journal Article] Design and synthesis of isonucleosides constructed on a 2-Oxa-6-thiabicyclo[3.2.0]heptane scaffold (2010)
  • Author(s): Yoshimura Y, Asami K, Imamichi T, Okuda T, Shiraki K, Takahata H.
  • Journal Title: J Org Chem Volume: 75 Pages: 4161-4171
  • Peer Reviewed
• [Journal Article] Varicella-zoster virus keratitis with asymptomatic conjunctival viral shedding in the contralateral eye
  • Author(s): Miyakoshi A, Takemoto M, Shiarki K, Hayashi A
  • Journal Title: Cornea in press
  • Peer Reviewed
• [Journal Article] A novel deletion in glycoprotein G forms a cluster and causes immune evasion in herpes simplex virus type 2 infection
  • Author(s): Daikoku T, Horiba K, Kawana T, Hirano M, Shiraki K
  • Journal Title: Journal of Medical Virology in press
  • Peer Reviewed
• [Presentation] 帯状疱疹の2回発症 (2012)
  • Author(s): 白木公康,大黒 徹
  • Organizer: 第53回日本臨床ウイルス学会
  • Place of Presentation: 豊中
  • Year and Date: 2012-06-17
• [Presentation] 抗gH抗体によるVZV潜伏感染誘導時の転写産物の解析 (2012)
  • Author(s): 黒 徹,武本眞清,白木公康
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 水痘帯状疱疹ウイルスの糖蛋白gHに対する抗体が引き起こす抗原変調作用の解析 (2012)
  • Author(s): 武本眞清,大黒 徹,吉田与志博,浅野 喜造,白木公康
  • Organizer: 第60回日本ウイルス学会学術集会
  • Place of Presentation: 大阪
• [Presentation] The fate of VZV gH in the infected cells treated with antigH-Mab (2012)
  • Author(s): Takemoto M, Daikoku T, Asano Y, Shiraki K
  • Organizer: 37th Annual International Herpesvirus workshop
  • Place of Presentation: Calgary, Canada.
• [Presentation] The fate of VZV gH in the infected cells treated with anti-gH-MAb. (2012)
  • Author(s): Takemoto M, Daikoku T, Asano Y, Shiraki K
  • Organizer: 37th Annual International Herpesvirus workshop
  • Place of Presentation: Calgary,Canada
• [Presentation] 帯状疱疹の2回発症 (2011)
  • Author(s): 白木公康,大黒 徹
  • Organizer: 第15回日本ワクチン学会学術集会
  • Place of Presentation: 東京
• [Presentation] 水痘ワクチンの抗体測定におけるIAHA法の有用性 (2011)
  • Author(s): 尾崎隆男,西村直子,中根一匡,舟橋恵二,白木公康,浅野章造,前田一洋,奥野良信
  • Organizer: 第15回日本ワクチン学会学術集会
  • Place of Presentation: 東京
• [Presentation] 単純ヘルペスウイルス2 型glycoprotein Gに欠失の認められた性器ヘルペス患者の血清学的解析 (2011)
  • Author(s): 白木公康
  • Organizer: 日本性感染症学会第24回学術大会
  • Place of Presentation: 東京
• [Presentation] Neutralizing anti-gH antibody of varicella-zoster virus modulated distribution of gH and induced gene regulation mimicking latency (2011)
  • Author(s): Shiraki K
  • Organizer: 15th International Conference on the Immunobiology and Prophylaxis of Herpesvirus Infections
  • Place of Presentation: San Servolo, Venice
• [Presentation] Clinical and epidemiologicrelevance of a novel 21 amino aciddeletion in glycoprotein G of clinicalherpes simplex virus type 2 isolates (2011)
  • Author(s): Daikoku T, Horiba K, Takemoto M, Himaki T, Kawana T, Hirano M, Shiraki K
  • Organizer: International Union of Microbiological Societies 2011 congress
  • Place of Presentation: Sapporo.
• [Presentation] Aberrant VZV glycoproteins traffic modulated byneutralizing anti-gH mab (2011)
  • Author(s): Takemoto M, Daikoku T, Suzuki K, Akahori Y, Kurosawa Y, AsanoY, Shiraki K
  • Organizer: International Union of Microbiological Societies 2011 congress
  • Place of Presentation: Sapporo.
• [Presentation] タンポポによる単純ヘルペスウイルス1型およびインフルエンザウイルスの増殖抑制 (2011)
  • Author(s): 武本眞清,薄 海霞,大黒 徹 ,邵 輝,白木公康
  • Organizer: 第28回和漢医薬学会学術大会
  • Place of Presentation: 富山
• [Presentation] Epidemiology of the second episode of herpes zoster (II) (2011)
  • Author(s): Shiraki K, Toyama N, Daikoku T
  • Organizer: 36th Annual International Herpesvirus Workshop
  • Place of Presentation: Gdansk, Poland
• [Presentation] A novel deletion in glycoprotein G causes epidemiologic spread and immune evasion in herpes simplex virus type 2 infection (2011)
  • Author(s): Daikoku T, Horiba K, Kawana T, Hirano M, Shiraki K
  • Organizer: 36th Annual International Herpesvirus Workshop
  • Place of Presentation: Gdansk, Poland.
• [Presentation] Aberrant VZV glycoprotein traffic modulated by neutralizing anti-gH-mab (2011)
  • Author(s): Takemoto M, Daikoku T, Suzuki K, Akahori Y, Kurosawa Y, Asano Y, Shiraki K
  • Organizer: 36th Annual International Herpesvirus Workshop
  • Place of Presentation: Gdansk, Poland.
• [Presentation] 帯状疱疹特有の疼痛の発症メカニズム (2011)
  • Author(s): 白木公康,大黒 徹,武本眞清
  • Organizer: 第52回日本臨床ウイルス学会
  • Place of Presentation: 津
• [Presentation] 帯状疱疹と帯状疱疹予防ワクチン (2011)
  • Author(s): 白木公康
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
• [Presentation] Epidemiology of the second episode of herpes zoster (II) (2011)
  • Author(s): Shiraki K, Toyama N, Daikoku T
  • Organizer: 36th annual international herpesvirus workshop
  • Place of Presentation: The Polish Baltic Frederic Chopin Philharmonic Hall (Gdansk, Poland)
• [Presentation] A novel deletion in glycoprotein G causes epidemiologic spread and immune evasion in herpes simplex virus type 2 infection (2011)
  • Author(s): Daikoku T, Horiba K, Kawana T, Hirano M, Shiraki K
  • Organizer: 36th annual international herpesvirus workshop
  • Place of Presentation: The Polish Baltic Frederic Chopin Philharmonic Hall (Gdansk, Poland)
• [Presentation] Aberrant VZV glycoprotein traffic modulated by neutralizing anti-gH-mab (2011)
  • Author(s): Takemoto M, Daikoku T, Suzuki K, Akahori Y, Kurosawa Y, Asano Y, Shiraki K
  • Organizer: 36th annual international herpesvirus workshop
  • Place of Presentation: The Polish Baltic Frederic Chopin Philharmonic Hall (Gdansk, Poland)
• [Presentation] A Neutralizing anti-gH antibody of varicella-zoster virus modulated distribution of gH and induced gene regulation mimicking latency (2011)
  • Author(s): Shiraki K
  • Organizer: 15th International Conference on the Immunobiology and Prophylaxis of Herpesvirus Infections
  • Place of Presentation: The conference center on San Servolo (San Servolo, Venice)
• [Presentation] Clinical and epidemiologic relevance of a novel 21 amino acid deletion in glycoprotein G of clinical herpes simplex virus type 2 isolates (2011)
  • Author(s): Daikoku T, Horiba K, Takemoto M, Himaki T, Kawana T, Hirano M, Shiraki K
  • Organizer: International Union of Microbiological Societies 2011 congress
  • Place of Presentation: Sapporo Convention Center (Sapporo)
• [Presentation] Aberrant VZV glycoproteins traffic modulated by neutralizing anti-gH mab (2011)
  • Author(s): Takemoto M, Daikoku T, Suzuki K, Akahori Y, Kurosawa Y, Asano Y, Shiraki K
  • Organizer: International Union of Microbiological Societies 2011 congress
  • Place of Presentation: Sapporo Convention Center (Sapporo)
• [Presentation] 帯状疱疹と帯状疱疹予防ワクチン (2011)
  • Author(s): 白木公康
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 国立京都国際会館(京都)(招待講演)
• [Presentation] 帯状疱疹特有の疼痛の発症メカニズム (2011)
  • Author(s): 白木公康, 大黒徹, 武本眞清
  • Organizer: 第52回日本臨床ウイルス学会
  • Place of Presentation: 三重県総合文化センター(津)
• [Presentation] タンポポによる単純ヘルペスウイルス1型およびインフルエンザウイルスの増殖抑制 (2011)
  • Author(s): 武本眞清, 薄海霞, 大黒徹, 邵輝, 白木公康
  • Organizer: 第28回和漢医薬学会学術大会
  • Place of Presentation: 富山県民会館(富山)
• [Presentation] 単純ヘルペスウイルス2型glycoprotein Gに欠失の認められた性器ヘルペス患者の血清学的解析 (2011)
  • Author(s): 白木公康
  • Organizer: 日本性感染症学会第24回学術大会
  • Place of Presentation: 都市センターホテル(東京)
• [Presentation] 帯状疱疹の2回発症 (2011)
  • Author(s): 白木公康, 大黒徹
  • Organizer: 第15回日本ワクチン学会学術集会
  • Place of Presentation: 日本教育会館(東京)
• [Presentation] 新しく開発した気管支モデルによる水痘生ワクチンの経鼻投与3法の気道内到達深度比較試験 (2011)
  • Author(s): 馬場宏一, 白木公康, 奥野壽臣, 山西弘一, 高橋理明
  • Organizer: 第15回日本ワクチン学会学術集会
  • Place of Presentation: 日本教育会館(東京)
• [Presentation] 水痘ワクチンの抗体測定におけるIAHA法の有用性 (2011)
  • Author(s): 尾崎隆男, 西村直子, 中根一匡, 舟橋恵二, 白木公康, 浅野章造, 前田一洋, 奥野良信
  • Organizer: 第15回日本ワクチン学会学術集会
  • Place of Presentation: 日本教育会館(東京)
• [Presentation] 帯状疱疹の疼痛メカニズムと帯状疱疹予防ワクチンの必要性 (2010)
  • Author(s): 白木公康,大黒 徹
  • Organizer: 第14回日本ワクチン学会学術集会
  • Place of Presentation: 東京
• [Presentation] Epidemiology of the second episode of herpes zoster (2010)
  • Author(s): Shiraki K, Toyama N
  • Organizer: 35th Annual International Herpesvirus Workshop
  • Place of Presentation: Salt Lake City, USA
• [Presentation] VZV gene transcription in cells treated with anti-gH antibody during the quiescent state (2010)
  • Author(s): Daikoku T, Takemoto M, Suzuki K, Akahori Y, Kurosawa Y, Asano Y, Shiraki K
  • Organizer: 35th Annual International Herpesvirus workshop
  • Place of Presentation: Salt Lake City, USA
• [Presentation] Anti-gH neutralizing antibody alters localization of VZV glycoprotein B and E (2010)
  • Author(s): Takemoto M, Daikoku T, Suzuki K, Akahori Y, Kurosawa Y, Asano Y, Shiraki K
  • Organizer: 35th Annual International Herpesvirus Workshop
  • Place of Presentation: Salt Lake City, USA
• [Presentation] 水痘・帯状疱疹ウイルスglycoprotein Hに対する中和抗体による、細胞内ウイルスの感染性消失過程の解析 (2010)
  • Author(s): 武本眞清,大黒 徹,吉田与志博,浅野喜造,白木公康
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] Role of anti-gH neutralizing antibody in varicellazoster virus (2010)
  • Author(s): Shiraki K
  • Organizer: The 8th China-Japan International Conference of Virology
  • Place of Presentation: Harbin, China
• [Presentation] Role of anti-gH neutralizing antibody in varicella-zoster virus (2010)
  • Author(s): Shiraki K
  • Organizer: The 8th China-Japan International Conference of Virology
  • Place of Presentation: Harbin
• [Presentation] Epidemiology of the second episode of herpes zoster (2010)
  • Author(s): Shiraki K, Toyama N
  • Organizer: 35th Annual International Herpesvirus Workshop
  • Place of Presentation: Salt Lake City
• [Presentation] VZV gene transcription in cells treated with anti-gH antibody during the quiescent state (2010)
  • Author(s): Daikoku T, Takemoto M, Suzuki K, Akahori Y, Kurosawa Y, Asano Y, Shiraki K
  • Organizer: 35th Annual International Herpesvirus workshop
  • Place of Presentation: Salt Lake City.
• [Presentation] Anti-gH neutralizing antibody alters localization of VZV glycoprotein B and E (2010)
  • Author(s): Takemoto M, Daikoku T, Suzuki K, Akahori Y, Kurosawa Y, Asano Y, Shiraki K
  • Organizer: 35th Annual International Herpesvirus Workshop
  • Place of Presentation: Salt Lake City.
• [Presentation] 水痘・帯状庖疹ウイルスglycoprotein Hに対する中和抗体による、細胞内ウイルスの感染性消失過程の解析 (2010)
  • Author(s): 武本眞清, 大黒徹, 吉田与志博, 浅野喜造, 白木公康
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] 単純ヘルペスウイルス1型感染に対するプロポリスの病態改善効果の解析 (2010)
  • Author(s): 吉田裕樹, 甲斐久博, 堤重敏, 安川憲, 渡辺渡, 松野康二, 白木公康, 黒川昌彦
  • Organizer: 第58回日本ウイルス学会学術集会
  • Place of Presentation: 徳島
• [Presentation] 帯状庖疹の痙痛メカニズムと帯状庖疹予防ワクチンの必要性 (2010)
  • Author(s): 白木公康, 大黒徹
  • Organizer: 第14回日本ワクチン学会学術集会
  • Place of Presentation: 東京
• [Book] 水痘帯状疱疹ウイルスの基礎.「水痘・帯状疱疹のすべて」 (2012)
  • Author(s): 白木公康,大黒 徹,武本眞清
  • Publisher: 浅野喜造編集,メジカルビュー社
• [Book] 帯状疱疹の痛みはなぜ強い?「水痘・帯状疱疹のすべて」 (2012)
  • Author(s): 白木公康
  • Total Pages: 201
  • Publisher: 浅野喜造編集,メジカルビュー社
• [Book] 水痘ワクチンの定期接種化で帯状疱疹はどうなる?「水痘・帯状疱疹のすべて」 (2012)
  • Author(s): 白木公康
  • Total Pages: 225
  • Publisher: 浅野喜造編集,メジカルビュー社
• [Book] 「水痘・帯状疱疹のすべて」水痘帯状疱疹ウイルスの基礎，浅野喜造編集 (2012)
  • Author(s): 白木公康，大黒 徹，武本眞清
  • Publisher: メジカルビュー社
• [Book] 「水痘・帯状疱疹のすべて」帯状疱疹の痛みはなぜ強い？，浅野喜造編集 (2012)
  • Author(s): 白木公康
  • Total Pages: 201
  • Publisher: メジカルビュー社
• [Book] 「水痘・帯状疱疹のすべて」水痘ワクチンの定期接種化で帯状疱疹はどうなる？，浅野喜造編集 (2012)
  • Author(s): 白木公康
  • Total Pages: 225
  • Publisher: メジカルビュー社
• [Book] 帯状疱疹はなぜ片側にしか生じないのか? 「眼のサイエンス 眼疾患の謎」 (2010)
  • Author(s): 白木公康
  • Publisher: 根木 昭 他編,文光堂
• [Book] 眼のサイエンス眼疾患の謎 (2010)
  • Author(s): 白木公康, 他著, 根木昭, 他編
  • Publisher: 文光堂
• [Remarks] メディカルトリビュニーシ「帯沃庖疹に伴う痛覚過敏のメカニズム」に掲載される。
  • URL: http://mtpro.medical-tribune.co.jp/article/view/perpage/1/order/1/page/0/id/M43210351/year/2010
• [Remarks] 韓国公共放送KBS「生老病死の秘密」第348回の「水痘帯状庖疹ウイルスの逆襲:帯状庖疹」に取り上げられる。
  • URL: http://www.u-toyama.ac.jp/jp/publicity/pr2010/pdf/54.pdf