Research on basic mechanisms of gastric hyperalgesia in animal model of functional dyspepsia
| Project/Area Number |
22600004
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YI Tsutomu 首都大学東京, 健康福祉学部, 教授 (70334753)
YAMAGUCHI Takeshi 金沢大学, 医学系, 助教 (60532182)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 機能性胃腸症 / ストレス / CRF / CRF2 / 内臓痛 / 胃 |
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| Research Abstract |
Repetitive WA-S developed gastric hyperalgesia even in the absence of detectable gastric pathology, suggesting its suitability for a potential animal model of FD. CRF2 receptor play an important role in gastric hyperalgesia observed after the stress. CRF2 receptor signaling may be useful therapeutic targets for FD.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Involvement of NGF in the rat model of persistent muscle pain associated with taut band2011
Author(s)
Hayashi K, Ozaki N, Kawakita K, Itoh K, Mizumura K, Furukawa K, Yasui M, Hori K, Yi SQ, Yamaguchi T, Sugiura Y
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Journal Title
J Pain
Volume: 12
Issue: 10
Pages: 1059-1068
DOI
NAID
Related Report
Peer Reviewed
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