The mechanism of hyperalgesia in the spinal dorsal horn revealed by imaging of neuronal activity

• Project/Area Number: 22600005
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: University of Fukui
• Principal Investigator: IKEDA Hiroshi 福井大学, 大学院・工学研究科, 教授 (80377473)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 痛覚 / イメージング / 脊髄後角 / グリア細胞 / 神経可塑性 / 痛覚過敏 / 膜電位イメージング / カルシウムイメージング / アストロサイト / 電位イメージング

Research Abstract

There are distinct glia-related mechanisms for the central sensitization in different persistent pain, that is microglia-related and astrocyte-related mechanisms in neuropathic and inflammatory pain, respectively.

Research Products

• [Journal Article] Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat (2012)
  • Author(s): Ikeda H, Kiritoshi T, Murase K
  • Journal Title: Molecular Pain Volume: 8
  • Peer Reviewed
• [Journal Article] Effect of dietary zinc deficiency on ischemic vulnerability of the brainEffect of dietary zinc deficiency on ischemic vulnerability of the brain (2012)
  • Author(s): Omata N, Murata T, Maruoka N, Ikeda H, Mitsuya H, Mizuno T, Mita K, Asano M, Kiyono Y, Okazawa H, Wada Y
  • Journal Title: Neuroscience Letters Volume: 531 Pages: 10-13
  • Peer Reviewed
• [Journal Article] Contribution of microglia and astrocytes to the central sensitization, inflammatory and neuropathic pain in the juvenile rat. (2012)
  • Author(s): Ikeda H
  • Journal Title: Molecular Pain Volume: 8 Pages: 1-10
  • DOI: 10.1186/1744-8069-8-43
  • Peer Reviewed
• [Journal Article] Long-term potentiation of neuronal excitation in the central nucleus of the rat amygdala revealed by imaging with a voltage-sensitive dye (2010)
  • Author(s): Ikeda H, Kiritoshi T, Murase K
  • Journal Title: Brain Research Volume: 1349 Pages: 32-40
  • Peer Reviewed
• [Journal Article] Local administration of a synthetic cell-penetrating peptide antagonizing TrkA function suppresses inflammatory pain in rats (2010)
  • Author(s): Ueda K, Hirose M, Murata E, Takatori M, Ueda M, Ikeda H, Shigemi K
  • Journal Title: Journal of Pharmacological Science Volume: 112 Pages: 438-443
  • NAID: 10027909112
  • Peer Reviewed
• [Journal Article] Long-term potentiation of neuronal excitation in the central nucleus of the rat amygdala revealed by imaging with a voltage-sensitive dye. (2010)
  • Author(s): Ikeda H, Kiritoshi T, Murase K.
  • Journal Title: Brain Research Volume: 1349 Pages: 32-40
  • Peer Reviewed
• [Journal Article] Local administration of a synthetic cell-penetrating peptide antagonizing TrkA function suppresses inflammatory pain in rats. (2010)
  • Author(s): Ueda K, Hirose M, Murata E, Takatori M, Ueda M, Ikeda H, Shigemi K.
  • Journal Title: Journal of Pharmacological Science Volume: 112 Pages: 438-443
  • NAID: 10027909112
  • Peer Reviewed
• [Presentation] Contribution of the descending pain inhibitory system to the analgesic effect by smelling the aroma oil (2012)
  • Author(s): 高須 俊太郎, 池田 弘, 村瀬 一之, 竹内 翔汰
  • Organizer: 第35回日本神経科学学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2012-09-19
• [Presentation] 前帯状回における神経興奮の長期増強へのアストロサイトの関与 (2012)
  • Author(s): 池田 弘, 林 努, 村瀬 一之
  • Organizer: 第35回日本神経科学学会
  • Place of Presentation: 愛知県名古屋市
  • Year and Date: 2012-09-19
• [Presentation] Astrocyte involves in the long-term facilitation of neuronal excitation in the anterior cingulate cortex of mice with inflammatory pain (2012)
  • Author(s): H. Ikeda, K. Mochizuki, K. Murase
  • Organizer: NIPS-WS 2012 Central Neuroplasticity in Sensory Emotional Link
  • Place of Presentation: 愛知県岡崎市
  • Year and Date: 2012-09-13
• [Presentation] 脊髄後角における神経可塑性機構の膜電位感受性色素を用いた光学的イメージングによる解析 (2012)
  • Author(s): 池田弘, 村瀬一之
  • Organizer: 第89回日本生理学会
  • Place of Presentation: 松本(招待講演)
  • Year and Date: 2012-03-30
• [Presentation] Differential contribution of microglia and astrocytes to the central sensitization under peripheral nerve injury and tissue inflammation (2011)
  • Author(s): 池田 弘 , 村瀬 一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2011-09-16
• [Presentation] Agumentation of neuronal excitability by glial cells in the rat spinal dorsal horn under persistent pain state revealed by optical imaging with voltage-sensitive dye. (2011)
  • Author(s): 村山 美郷 , 池田 弘 , 村瀬 一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2011-09-16
• [Presentation] Differential contribution of microglia and astrocytes to the central sensitization under peripheral nerve injury and tissue inflammation (2011)
  • Author(s): 池田弘, 村瀬一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Agumentation of neuronal excitability by glial cells in the rat spinal dorsal horn under persistent pain state revealed by optical imaging with voltage-sensitive dye (2011)
  • Author(s): 村山美郷, 池田弘, 村瀬一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Influence of inhibitory input to tonotopic organization of the inferior colliculus by voltage and Ca^<2+> imaging (2011)
  • Author(s): 平田雄大, 伊藤哲史, 池田弘, 村瀬一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Activation of emotional and descending pain inhibitory system in the brain to inhibition of pain after inflammation by lemon odor (2011)
  • Author(s): 竹内祥太, 池田弘, 村瀬一之
  • Organizer: 第34回日本神経科学学会
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Contribution of emotional and descending pain inhibitory system in the brain to analgesia effect of lemon odor (2011)
  • Author(s): 竹内 祥太 , 池田 弘 , 村瀬 一之
  • Organizer: 第33回日本疼痛学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2011-07-22
• [Presentation] Role of glial cells to the neuronal plasticity in the spinal dorsal horn under hyperalgesia (2011)
  • Author(s): 池田 弘, 村瀬 一之
  • Organizer: 第33回日本疼痛学会
  • Place of Presentation: 愛媛県松山市
  • Year and Date: 2011-07-22
• [Presentation] Contribution of emotional and descending pain inhibitory system in the brain to analgesia effect of lemon odor (2011)
  • Author(s): 竹内祥太, 池田弘, 村瀬一之
  • Organizer: 第33回日本疼痛学会
  • Place of Presentation: 愛媛
  • Year and Date: 2011-07-22
• [Presentation] Role of glial cells to the neuronal plasticity in the spinal dorsal horn under hyperalgesia (2011)
  • Author(s): 池田弘, 村瀬一之
  • Organizer: 第33回日本疼痛学会
  • Place of Presentation: 愛媛
  • Year and Date: 2011-07-22
• [Presentation] Contribution of the glial activity to the facilitation of neuronal excitation in the rat spinal dorsal horn under neuropathic pain (2010)
  • Author(s): Ikeda H, Kiritoshi T, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04
• [Presentation] Involvement of protein kinases in pain-related synaptic plasticity in the rat central nucleus of the amygdala (2010)
  • Author(s): Kiritoshi T, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04
• [Presentation] The mechanism of long-term facilitation of optically-recorded neuronal excitation and the effect of mu-opioid receptor agonist DAMGO in the rat central nucleus of the amygdala (2010)
  • Author(s): Ebuchi T, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04
• [Presentation] Contribution of glial cells on the optically-recorded neuronal excitation in the rat spinal dorsal horn under neuropathic pain (2010)
  • Author(s): Murayama M, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2010-09-04
• [Presentation] Contribution of the glial activity to the facilitation of neuronal excitation in the rat sninal dorsal horn under neuropathic pain (2010)
  • Author(s): Ikeda H, Kiritoshi T, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Involvement of protein kinases in pain-related synaptic plasticity in the rat central nucleus of the amygdala (2010)
  • Author(s): Kiritoshi T, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] The mechanism of long-term facilitation of optically-recorded neuronal excitation and the effect of mu-opioid receptor agonist DAMGO in the rat central nucleus of the amygdala (2010)
  • Author(s): Ebuchi T, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Contribution of glial cells on the optically-recorded neuronal excitation in the rat spinal dorsal horn under neuronathic pain (2010)
  • Author(s): Murayama M, Ikeda H, Murase K
  • Organizer: Neuro2010
  • Place of Presentation: 神戸
  • Year and Date: 2010-09-04
• [Presentation] Contribution of the descending pain inhibitory system to the analgesic effect by smelling the aroma oil.
  • Author(s): 高須 俊太郎
  • Organizer: 第35回日本神経科学学会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] 前帯状回における神経興奮の長期増強へのアストロサイトの関与
  • Author(s): 池田 弘,
  • Organizer: 第35回日本神経科学学会
  • Place of Presentation: 愛知県名古屋市
• [Presentation] Astrocyte involves in the long-term facilitation of neuronal excitation in the anterior cingulate cortex of mice with inflammatory pain.
  • Author(s): H. Ikeda
  • Organizer: NIPS-WS 2012 Central Neuroplasticity in Sensory Emotional Link
  • Place of Presentation: 愛知県岡崎市