Analysis for the touch and pain receptive network formation

• Project/Area Number: 22600011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 疼痛学
• Research Institution: Keio University
• Principal Investigator: SHIBATA Shinsuke 慶應義塾大学, 医学部, 助教 (70407089)
• Co-Investigator(Renkei-kenkyūsha): SATO Momoka 慶應義塾大学, 医学部, 特別研究助教 (00548513) ; NAGOSHI Narihito 独立行政法人国立病院機構村山医療センター, 整形外科, 研究員 (10383837)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 神経栄養因子 / 感覚神経 / 神経幹細胞 / 触覚 / 痛覚 / 背側神経節 / 神経科学 / 温痛覚 / 神経発生学

Research Abstract

The expression regulatory mechanism of Pleiotrophin by the RNA-binding protein Musashi2 is quite important for normal sensory network formation during development through the evidences of abnormal sensation in Pleiotrophin and Musashi2 knockout mice. It i

Research Products

• [Journal Article] Sema3A regulates bone-mass accrual through sensory innervations (2013)
  • Author(s): Fukuda T, Takeda S, Xu R, Ochi H, Sunamura S, Sato T, Shibata S, Yoshida Y, Gu Z, Kimura A, Ma C, Xu C, Bando W, Fujita K, Shinomiya K, Hirai T, Asou Y, Enomoto M, Okano H, Okawa A, Itoh H
  • Journal Title: Nature. Volume: 497 Issue: 7450 Pages: 490-493
  • DOI: 10.1038/nature12115
  • Peer Reviewed
• [Journal Article] Sox10 is a novel marker of acinus and intercalated duct differentiation in salivary gland tumors: A clue to the histogenesis and diagnosis (2013)
  • Author(s): Ohtomo R, Mori T, Shibata S, Tsuta K, Maeshima M, Akazawa C, Honda K, Yamada T, Yoshimoto S, Asai M, Okano H, Kanai Y, Tsuda H
  • Journal Title: Modern Pathology Volume: Aug;26(8): Issue: 8 Pages: 1041-50
  • DOI: 10.1038/modpathol.2013.54
  • Peer Reviewed
• [Journal Article] Musashi-1 post-transcriptionally enhances phosphotyrosine-binding domain- containing m-Numb protein expression in regenerating gastric mucosa. (2013)
  • Author(s): Tetsufumi Takahashi
  • Journal Title: PLoS One Volume: 8 Issue: 1 Pages: 1-13
  • DOI: 10.1371/journal.pone.0053540
  • Peer Reviewed
• [Journal Article] MRI characterization of paranodal junction failure and related spinal cord changes in mice (2012)
  • Author(s): Takano M, Hikishima K, Fujiyoshi K, Shibata S, Yasuda A, Konomi T, Hayashi A, Baba H, Honke K, Toyama Y, Okano H, Nakamura M.
  • Journal Title: PLoS One Volume: 7(12) Issue: 12 Pages: e52904-e52904
  • DOI: 10.1371/journal.pone.0052904
  • Peer Reviewed
• [Journal Article] Novel in vivo imaging analysis of an inner ear drug delivery system in mice: Comparison of inner ear drug concentrations over time after transtympanic and systemic injections (2012)
  • Author(s): Kanzaki S, Fujioka M, Yasuda A, Shibata S, Nakamura M, Okano HJ, Ogawa K, Okano H.
  • Journal Title: PLoS One Volume: 7(12) Issue: 12 Pages: e48480-e48480
  • DOI: 10.1371/journal.pone.0048480
  • Peer Reviewed
• [Journal Article] The Semaphorin 3A Inhibitor SM-345431 Accelerates Peripheral Nerve Regeneration and Sensitivity in a Murine Corneal Transplantation Model. (2012)
  • Author(s): 大元雅弘
  • Journal Title: PLoS One Volume: 7(11) Issue: 11 Pages: e47716-e47716
  • DOI: 10.1371/journal.pone.0047716
  • Peer Reviewed
• [Journal Article] Sustained bFGF-Release Tubes for Peripheral Nerve Regeneration: Comparison with Autograft (2012)
  • Author(s): Takagi T, Kimura Y, Shibata S, Saito H, Ishii K, Okano HJ, Toyama Y, Okano H, Tabata Y, Nakamura M
  • Journal Title: Plast Reconstr Surg Volume: 130(4) Pages: 866-76
  • Peer Reviewed
• [Journal Article] Characterization of the RNA-binding protein Musashi1 in zebrafish. (2012)
  • Author(s): Shibata S, Umei M, Kawahara H, Yano M, Makino S, Okano H.
  • Journal Title: Brain Research Volume: 1462 Pages: 162-73
  • DOI: 10.1016/j.brainres.2012.01.068
  • Peer Reviewed
• [Journal Article] Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord. (2011)
  • Author(s): Yasuda A, Tsuji O, Shibata S, Nori S, Takano M, Kobayashi Y, Takahashi Y, Fujiyoshi K, Hara CM, Miyawaki A, Okano HJ, Toyama Y, Nakamura M, Okano H
  • Journal Title: Stem Cells Volume: 29(12) Issue: 12 Pages: 1983-94
  • DOI: 10.1002/stem.767
  • Peer Reviewed
• [Journal Article] Beneficial compaction of spinal cord lesion by migrating astrocytes through Glycogen Synthase Kinase-3 inhibition (2011)
  • Author(s): Renault-Mihara F, Katoh H, Ikegami T, Iwanami A, Mukaino M, Tada H, Yasuda A, Nori S, Shibata S, Saito K, Matsushita M, Kaibuchi K, Okada S, Toyama Y, Nakamura M, and Okano H
  • Journal Title: EMBO Mol Med Volume: 3 Issue: 11 Pages: 682-96
  • DOI: 10.1002/emmm.201100179
  • Peer Reviewed
• [Journal Article] Dysfunction of fibroblasts of extra-renal origin underlies renal fibrosis and renal anemia in mice (2011)
  • Author(s): Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K-i, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M
  • Journal Title: J Clin Invest Volume: 121 Issue: 10 Pages: 3981-3990
  • DOI: 10.1172/jci57301
  • Peer Reviewed
• [Journal Article] The dual origin of the peripheral olfactory system : placode and neural crest (2011)
  • Author(s): Katoh H, Shibata S, Fukuda K, Sato M, Satoh E, Nagoshi N, Minematsu T, Matsuzaki Y, Akazawa C, Toyama Y, Nakamura M, Okano H
  • Journal Title: Mol Brain Volume: 4 Issue: 1 Pages: 34-34
  • DOI: 10.1186/1756-6606-4-34
  • Peer Reviewed
• [Journal Article] Schwann-spheres derived from injured peripheral nerves in adult mice--their in vitro characterization and therapeutic potential. (2011)
  • Author(s): Takagi T, Ishii K, Shibata S, Yasuda A, Sato M, Nagoshi N, Saito H, Okano HJ, Toyama Y, Okano H, Nakamura M
  • Journal Title: PLoS One Volume: 6(6) Issue: 6 Pages: e21497-e21497
  • DOI: 10.1371/journal.pone.0021497
  • Peer Reviewed
• [Journal Article] Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing (2011)
  • Author(s): Nagoshi N, Shibata S, Hamanoue M, Mabuchi Y, Matsuzaki Y, Toyama Y, Nakamura M, Okano H
  • Journal Title: Glia Volume: 59(5) Issue: 5 Pages: 771-84
  • DOI: 10.1002/glia.21150
  • Peer Reviewed
• [Journal Article] Expression and Function of Sox21 During Mouse Cochlea Development. (2011)
  • Author(s): Hosoya M, Fujioka M, Matsuda S, Ohba H, Shibata S, Nakagawa F, Watabe T, Wakabayashi KI, Saga Y, Ogawa K, Okano HJ, Okano H
  • Journal Title: Neurochem Res Volume: 36(7) Issue: 7 Pages: 1261-9
  • DOI: 10.1007/s11064-011-0416-3
  • Peer Reviewed
• [Journal Article] Expression and Function of Sox21 During Mouse Cochlea Development. (2011)
  • Author(s): Hosoya M, Fujioka M, Matsuda S, Ohba H, Shibata S.Nakagawa F, Watabe T, Wakabayashi KI, Saga Y, Ogawa K, Okano HJ, Okano H.
  • Journal Title: Neurochemistry Research Volume: (e-pub)
  • Peer Reviewed
• [Journal Article] Sox10-Venus mice: a new tool for real time labelling of neural crest lineage and oligodendrocytes (2010)
  • Author(s): Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, Okano H.
  • Journal Title: Molecular Brain. Volume: 3(1) Pages: 31-31
  • Peer Reviewed
• [Journal Article] Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture (2010)
  • Author(s): Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Kusuda Furue M
  • Journal Title: Int. J. Dev. Biol. Volume: 54(8-9) Pages: 1287-1294
  • Peer Reviewed
• [Journal Article] The Neural Stem/progenitor Cell Marker Nestin is Expressed in Proliferative Endothelial Cells, but Not in Mature Vasculature (2010)
  • Author(s): Suzuki S, Namiki J, Shibata S, Mastuzaki Y, Okano H.
  • Journal Title: Journal of Histochemistry and Cytochemistry Volume: 58(8) Pages: 721-730
  • Peer Reviewed
• [Journal Article] Sox10-Venus mice : a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes. PMID : 21034515 (2010)
  • Author(s): Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, Okano H.
  • Journal Title: Molecular Brain. Volume: 3 Pages: 31-31
  • Peer Reviewed
• [Journal Article] Induction of neural crest cells from mouse embryonic stem cells in a serum-free monolayer culture (2010)
  • Author(s): Aihara Y, Hayashi Y, Hirata M, Ariki N, Shibata S, Nagoshi N, Nakanishi M, Ohnuma K, Warashina M, Michiue T, Uchiyama H, Okano H, Asashima M, Kusuda Furue M
  • Journal Title: International. Journal of Developmental Biology Volume: 54(8-9) Pages: 1287-1294
  • Peer Reviewed
• [Presentation] SENSORY NEURON TRAJECTORIES ARE REGULATED BY AN RNA-BINDING PROTEIN THAT MODIFIES EXPRESSION OF A NEUROTROPHIN (2013)
  • Author(s): Shibata S; Okano H
  • Organizer: The 11thAnnual Meeting of International Society for Stem Cell Research
  • Place of Presentation: Boston, USA
• [Presentation] Characterization of the RNA-binding protein Musashil in zebrafish (2012)
  • Author(s): Shibata S, Umei M, Kawahara H, Okano H
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス・ベルクラシック甲府(山梨県)
  • Year and Date: 2012-03-26
• [Presentation] Role of Musashi2 in Mechanoreceptive neural network formation (2012)
  • Author(s): Shibata S; Okano H
  • Organizer: The 11th Biennial Meeting of the Asian Pacific Society for Neurochemistry / The 55th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Kobe, Japan
• [Presentation] MECHANORECEPTIVE NEURAL NETWORK WITH RNA BINDING PROTEIN MUSASHI2 (2012)
  • Author(s): Shibata S; Okano H
  • Organizer: The 10^<th>Annual Meeting of International Society for Stem Cell Research 2012
  • Place of Presentation: Yokohama, Japan
• [Presentation] Characterization of the RNA-binding protein Musashi1 in zebrafish. (2012)
  • Author(s): Shibata S, Umei M, Kawahara H, Okano H
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨県甲府市
• [Presentation] MECHANORECEPTIVE NEURAL NETWORK WITH RNA BINDING PROTEIN MUSASHI2 (2012)
  • Author(s): Shibata S, Okano H
  • Organizer: The 10th Annual Meeting of International Society for Stem Cell Research
  • Place of Presentation: Yokohama, Japan
• [Presentation] 感覚神経ネットワーク形成を担うRNA結合蛋白質Musashi2 (2011)
  • Author(s): Shibata S, Okano H
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 瑠璃光(石川県)
  • Year and Date: 2011-09-27
• [Presentation] Sensory network formation with RNA binding protein Musashi2 (2011)
  • Author(s): Shibata S, Okano H
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-09-16
• [Presentation] 感覚神経ネットワーク形成を担うRNA結合蛋白質Musashi2 (2011)
  • Author(s): Shibata S, Okano H
  • Organizer: 第54回日本神経化学会大会
  • Place of Presentation: 石川県加賀市
• [Presentation] Sensory network formation with RNA binding protein Musashi2 (2011)
  • Author(s): Shibata S, Okano H
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Sox10-Venus mice: a new tool for real time labelling of neural crest lineage and oligodendrocytes (2011)
  • Author(s): Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, Okano H
  • Organizer: 第88回日本生理学会大会/第116回日本解剖学会総会・全国学術集会 合同大会
  • Place of Presentation: 神奈川県横浜市
• [Presentation] Touch and pain receptive network formation with RNA binding protein Musashi2 and Pleiotrophin (2010)
  • Author(s): Shibata S, Sakakibara SI, Furue H, Yoshimura M, Okano HJ, Okano H.
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: Sun Diego, United States
  • Year and Date: 2010-11-13
• [Presentation] Touch and pain receptive network formation with RNA binding protein Musashi2 and Pleiotrophin (2010)
  • Author(s): Shibata S; Sakakibara SI; Furue H; Yoshimura M; Okano HJ; Okano H
  • Organizer: Society for Neuroscience 2010
  • Place of Presentation: San Diego CA, USA
• [Presentation] New aspects on the migration and differentiation of neural crest stem cells (2010)
  • Author(s): Shibata S; Okano H
  • Organizer: 第33回日本神経科学大会Neuro2010 (Joint Conference of The 33rd annual Meeting of the Japan Neuroscience Society. The 53rd Annual Meeting of Japanese Society for Neurochemistry. The 20th Annual Meeting of Japanese Neural Network Society)
  • Place of Presentation: 兵庫県神戸市
• [Presentation] Sensory neural network formation with RNA binding protein Musashi2 (2010)
  • Author(s): Shibata S; Sakakibara SI; Furue H; Yoshimura M; Okano HJ; Okano H
  • Organizer: 第33回日本神経科学大会Neuro2010
  • Place of Presentation: 兵庫県神戸市
• [Presentation] Touch and pain receptive network formation with RNA binding protein Musashi2 and Pleiotrophin (2010)
  • Author(s): Shibata S, Sakakibara SI, Furue H, Yoshimura M, Okano HJ, Okano H.
  • Organizer: Japan Neuroscience Society Neuro2010
  • Place of Presentation: Kobe, Japan
• [Remarks]
  • URL: http://www.okano-lab.com/