Induction of P2Y receptors in the spinal cord following peripheral nerve injury.

Research Project

Project/Area Number	22600012
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	疼痛学
Research Institution	Kobe University
Principal Investigator	YANAMOTO Fujio 神戸大学, 医学研究科, 助教 (40368543)
Co-Investigator(Kenkyū-buntansha)	KOBAYASHI Kimiko 兵庫医科大学, 医学部, 助教 (70418961) MORIYAMA Kazuhide 兵庫医科大学, 医学部, 助教 (30301659)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	P2Y受容体 / 神経障害性疼痛 / 脊髄後角 / マイクログリア / ATP / P2Y / 神経因性疼痛
Research Abstract	Peripheral nerve injury can trigger neurological abnormalities, including neuropathic pain. Recent evidence shows that glial cells in the spinal cord play important roles in the mechanisms of neuropathic pain. In this study, we show that microglial P2Y receptors activated by peripheral nerve injury may play a key role in the development of neuropathic pain.

Report

(4 results)