The function of Na^+channel as a novel target molecule for chronic pain treatment in thalamus neuron
| Project/Area Number |
22600014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
疼痛学
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| Research Institution | International University of Health and Welfare |
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Principal Investigator |
AMANO Taku 国際医療福祉大学, 薬学部, 教授 (10294547)
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| Co-Investigator(Renkei-kenkyūsha) |
NAKATANI Yoshihiko 国際医療福祉大学, 薬学部, 助教 (40582169)
TSUJI Minoru 国際医療福祉大学, 薬学部, 准教授 (70297307)
MIYAGAWA Kazuya 国際医療福祉大学, 薬学部, 講師 (10453408)
KATOH Hideaki 国際医療福祉大学, 薬学部, 講師 (30438220)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナトリウムチャネル / Na+チャネル / モルヒネ / フェンタニール / オキシコドン / 慢性疼痛 / HEK293細胞 / 視床スライス / 微小興奮性シナプス後電流 / ナトリウムチャネルサブタイプ / 神経科学 / 電気生理学 |
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| Research Abstract |
In conclusion, we have found that morphine may induce cell-dependent dual modulation of glutamatergic synaptic transmission in the habenular nucleus. Moreover, it is our conclusion that morphine, fentanyl and oxycodone each produce the mu-opioid receptor-independent suppression of sodium currents by distinct mechanisms in thalamic neurons.
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Report
(4 results)
Research Products
(24 results)
