A marine lethal toxin polycavernoside A: synthesis and exploration of the molecular mechanism of action
| Project/Area Number |
22603001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
ケミカルバイオロジー
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| Research Institution | Tohoku University |
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Principal Investigator |
KASAI Yusuke 東北大学, 大学院・生命科学研究科, 産学官連携研究員 (50379286)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 天然物化学 / 海産毒 / 有機合成 / 鈴木-宮浦反応 / マクロラクトン化 / ポリカバノシド / マクロリド配糖体 |
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| Research Abstract |
A total synthesis of (-)-polycavernoside A, a marine lethal toxin isolated from the edible alga Gracilaria edulis, has been achieved via a convergent approach. The synthesis is highlighted by catalytic asymmetric syntheses of the two key fragments and their union through Suzuki-Miyaura coupling and Keck macrolactonization. Efficient synthesis of L-fucosyl-D-xylose part was developed by using armed-disarmed concept.
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Report
(4 results)
Research Products
(9 results)
