Synthesis of the bioactive fluorescent molecules: (inspired by pluramycins)
Project/Area Number |
22603003
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
ケミカルバイオロジー
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
ANDO Yoshio 東京工業大学, 大学院・理工学研究科, 助教 (40532742)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 有機合成化学 / 天然物化学 / ケミカルバイオロジー / 生理活性物質 / プルラマイシン類 / C-グリコシド |
Research Abstract |
Development of synthetic route to the total synthesis of pluramycins, was studied. The efficient ways for the bis-C-glycoside and aglycon synthesis were developed. These methodologies were successfully applied to the total synthesis of the saptomycin B, which is one of the pluramycins. This synthetic route would be expanded as a fundamental technology to the synthesis of pluramycin derivatives and the studies of chemicalbiology.
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Report
(4 results)
Research Products
(23 results)
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[Presentation] サプトマイシンHの合成研究2012
Author(s)
前澤芳彦、北村圭、安藤吉勇、松本隆司、鈴木啓介
Organizer
日本化学会第92春季年会
Place of Presentation
慶應義塾大学(神奈川県)
Year and Date
2012-03-26
Related Report
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