| Project/Area Number |
22603007
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
|---|
| Research Field |
ケミカルバイオロジー
|
|---|
| Research Institution | University of the Ryukyus |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
NODA Naohiro 産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (70415727)
ANNO Kumiko 広島大学, 薬学部, 助教 (30452585)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | C 型肝炎ウイルス / NS3 ヘリケース / サンゴ礁生物 / 海綿 / ウミシダ / NS3ヘリケース / HCV / PBDE / C型肝炎ウイルス / psammaplin A / halenaquinol sulfate |
|---|
| Research Abstract |
To discover lead molecules against hepatitis C virus, we screened extracts of coral reef organisms with PET assay targeting NS3 helicase and with replicon assay utilizing cultured hepatocarcinoma cells transfected with virus-like genes. Hit extracts were subjected to chemical characterization to identify or determine the bioactive molecules. In addition, we examined the mode of action of the hit molecules.
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