Search and characterization of new helicase inhibitors and others from coral reef organisms
| Project/Area Number |
22603007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
ケミカルバイオロジー
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NODA Naohiro 産業技術総合研究所, バイオメディカル研究部門, 主任研究員 (70415727)
ANNO Kumiko 広島大学, 薬学部, 助教 (30452585)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | C 型肝炎ウイルス / NS3 ヘリケース / サンゴ礁生物 / 海綿 / ウミシダ / NS3ヘリケース / HCV / PBDE / C型肝炎ウイルス / psammaplin A / halenaquinol sulfate |
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| Research Abstract |
To discover lead molecules against hepatitis C virus, we screened extracts of coral reef organisms with PET assay targeting NS3 helicase and with replicon assay utilizing cultured hepatocarcinoma cells transfected with virus-like genes. Hit extracts were subjected to chemical characterization to identify or determine the bioactive molecules. In addition, we examined the mode of action of the hit molecules.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Psammaplin A inhibits hepatitis C virus NS3 helicase2013
Author(s)
Salam, K.A.; Furuta, A.; Noda, N.; Tsuneda, S.; Sekiguchi, Y.; Yamashita, A.; Moriishi, K.; Nakakoshi, M.; Tsubuki, M.; Tani, H.; Tanaka, J.; Akimitsu, N
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Journal Title
J. Nat. Med. in press
Volume: 67
Issue: 4
Pages: 765-772
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Real-time monitoring of RNA helicase activity using fluorescence resonance energy transfer in vitro2010
Author(s)
Tani, H.; Fujita, O.; Furuta, A.; Matsuda, Y.; Miyata, R.; Akimitsu, N.; Tanaka, J.; Tsuneda, S.; Sekiguchi, Y.; Noda, N.
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 393
Issue: 1
Pages: 131-136
DOI
Related Report
Peer Reviewed
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