The dynamic function of membrane-mimic bioactive substances

• Project/Area Number: 22603008
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: ケミカルバイオロジー
• Research Institution: Kanagawa University (2011-2012); Keio University (2010)
• Principal Investigator: NAKAMURA Kazuhiko 神奈川大学, 付置研究所, 研究員 (50286647)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 天然物化学 / 生理活性物質 / 炎症惹起物質 / プロテインキナーゼC / 海洋生物 / 植物成分 / メラニン生成阻害 / 生理活性発現機構 / 生体膜 / 有機合成化学 / 分解反応

Research Abstract

Chemical studies of complanine, an inflammatory substance isolated from a marine annelid, and related bioactive substances, were carried out. The closely related acetylenic amides to complanine were isolated from a plant resource, and the biological properties of these compounds were revealed. And a novel reaction by Grubbs catalyst was developed through analyzing chemical properties of such compounds.

Research Products

• [Journal Article] Grubbs carbene complex-catalyzed cleavage of allyl vic-diols to aldehydes with a co-oxidant: application to the selective cleavage of huge marine molecules (2011)
  • Author(s): C-G. Han, Y. Yamamoto, F. Kakiuchi, K. Nakamura, D.Uemura
  • Journal Title: Tetrahedron Volume: 9622-962 Issue: 49 Pages: 9622-9626
  • DOI: 10.1016/j.tet.2011.09.002
  • Peer Reviewed
• [Journal Article] Melanin Biosynthesis Inhibitors from Tarragon Artemisia dracunculus (2011)
  • Author(s): M.Yamada, K.Nakamura, T.Watabe, O.Ohno, M.Kawagoshi, N.Maru, N.Uotsu, T.Chiba, K.Yamaguchi, D.Uemura
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 75 Issue: 8 Pages: 1628-1630
  • DOI: 10.1271/bbb.110306
  • NAID: 10029592041
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Inhibitory Effects of Bakuchiol, Bavachin, and Isobavachalcone Isolated from Piper longum on Melanin Production in B16 Mouse Melanoma Cells (2010)
  • Author(s): Ohno, O.; Watabe, T.; Nakamura, K.; Kawagoshi, M.; Uotsu, N.; Chiba, T.; Yamada, M.; Yamaguchi, K.; Yamada, K.; Miyamoto, K.; Uemura, D.
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 74 Issue: 7 Pages: 1504-1506
  • DOI: 10.1271/bbb.100221
  • NAID: 10027557683
  • ISSN: 0916-8451, 1347-6947
  • Peer Reviewed
• [Journal Article] Neocomplanines A and B, a complanine family isolated from the marine fireworm Eurythoe complanata (2010)
  • Author(s): Nakamura, K; Tachikawa, Y.; Ohno, O.; Suganuma, M.; Kitamura, M.; Uemura, D.
  • Journal Title: J. Nat. Prod. Volume: 73 Issue: 3 Pages: 303-305
  • DOI: 10.1021/np900694j
  • Peer Reviewed
• [Journal Article] Neocomplanines A and B, a complanine family isolated from the marine fireworm Eurythoe complanata (2010)
  • Author(s): Nakamura, K., Tachikawa, Y., Ohno, O., Suganuma, M., Kitamura, M., Uemura, D.
  • Journal Title: J.Nat.Prod. Volume: 73 Pages: 303-305
  • Peer Reviewed
• [Journal Article] Inhibitory effects of bakuchiol, bavachin and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells (2010)
  • Author(s): Ohno, O., Watabe, T., Nakamura K., Kawagoshi, M., Uotsu, N.Chiba, T., Yamada, M., Yamaguchi, K., Yamada, K., Miyamoto, K., Uemura, D.
  • Journal Title: Biosci.Biotech.Biochem. Volume: 74 Pages: 1504-1506
  • NAID: 10027557683
  • Peer Reviewed
• [Presentation] Melanin Biosynthesis Inhibitors from Plant Resources (2011)
  • Author(s): Kazuhiko NAKMURA
  • Organizer: ICOB-7 & ISCNP-27: International Conference on Biodiversity and Natural Products
  • Place of Presentation: オーストラリア・ブリスベン
  • Year and Date: 2011-07-14
• [Presentation] Melanin Biosynthesis Inhibitors from Plant Resources (2011)
  • Author(s): Nakamura, K.; Ohno, O.; Yamada, M.; Watabe, T.; Kawagoshi, M.; Maru, N.; Uotsu, N.; Chiba, T.; Yamaguchi, K.; Uemura, D.
  • Organizer: ICOB-7 & ISCNP-27 : International Conference on Biodiversity and Natural Products
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2011-07-14
• [Presentation] タラゴンに含まれるメラニン生成阻害物質 (2011)
  • Author(s): 中村和彦
  • Organizer: 第91回日本化学会春季年会
  • Place of Presentation: 横浜
  • Year and Date: 2011-03-29
• [Presentation] Inhibitory effects ofprenylated phenolic compounds isolated from Piper longum on melanin biosynthesis in B16 cells (2010)
  • Author(s): KazuhikoNAKAMURA
  • Organizer: 学会名: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem2010)
  • Place of Presentation: アメリカ・ホノルル
  • Year and Date: 2010-12-19
• [Presentation] Biological Function ofComplanine and Related Compounds (2010)
  • Author(s): Kazuhiko NAKAMURA
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem2010)
  • Place of Presentation: アメリカ・ホノルル
  • Year and Date: 2010-12-19
• [Presentation] Inhibitory effects of prenylated phenolic compounds isolated from Piper longum on melanin biosynthesis in B16 cells (2010)
  • Author(s): Ohno, O., Watabe, T., NakamuraI K., Kawagishi, M., Uotsu, N.Chiba, T., Yamada, M., Yamaguchi, K., Yamada, K., Miyamoto, K., Uemura, D.
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem2010)
  • Place of Presentation: 米国ホノルル
  • Year and Date: 2010-12-19
• [Presentation] Biological Function of Complanine and Related Compounds (2010)
  • Author(s): Nakamura, K., Ohno, O., Uemura, D.
  • Organizer: 2010 International Chemical Congress of Pacific Basin Societies (Pacifichem2010)
  • Place of Presentation: 米国ホノルル
  • Year and Date: 2010-12-19
• [Presentation] ヒハツに含まれるメラニン生成阻害物質 (2010)
  • Author(s): 中村和彦
  • Organizer: 日本ケミカルバイオロジー学会第5回年会
  • Place of Presentation: 横浜
  • Year and Date: 2010-05-18
• [Presentation] Molecular Mechanism of Complanines, Inflammatory Substances Isolated from a Marine Annelid (2010)
  • Author(s): Nakamura, K., Ohno, O., Uemura, D.
  • Organizer: The 21^<st> French-Japanese Symposium on Medicinal and Fine Chemistry
  • Place of Presentation: 京都
  • Year and Date: 2010-05-10
• [Presentation] Molecular Mechanism of Complanines, Inflammatory Substances Isolated from a Marine Annelid (2010)
  • Author(s): Kazuhiko NAKAMURA
  • Organizer: The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
  • Place of Presentation: 京都
  • Year and Date: 2010-05-01
• [Patent(Industrial Property Rights)] メラニン産生抑制剤及び美白剤 (2012)
  • Inventor(s): 川越大、山田昌良、千場智尋、中村 和彦、大野修、渡部多恵子、上村大輔
  • Industrial Property Rights Holder: ファンケル(株)
  • Patent Publication Number: 2012-102063
  • Filing Date: 2012-05-31
• [Patent(Industrial Property Rights)] 特許 (2010)
  • Inventor(s): 川越大、山田昌良、千場智尋、中村和彦、大野修、渡部多恵子、上村大輔
  • Industrial Property Rights Holder: ファンケル(株)
  • Industrial Property Number: 2010-254171
  • Filing Date: 2010-10-21