| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Apidaecin is an antimicrobial peptide produced by honey bee. This peptide selectively inhibits the growth of Gram-negative bacteria such as Escherichia coli. In this study, the key amino acids in apidaecin sequence were substituted with other amino acids to improve the bacteriostatic activity and target selectivity of wild-type peptide. Interestingly, the resultant mutant peptides have shown potent activities for Gram-positive bacteria, which is originally insensitive to apidaecin. This finding has important implications for clarification of the action mechanism of apidaecin
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