| Project/Area Number |
22603013
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
ケミカルバイオロジー
|
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| Research Institution | Otsuma Women's University (2011-2012)
Waseda University (2010) |
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Principal Investigator |
ISHII Yoshitaka 大妻女子大学, 社会情報学部, 准教授 (70339688)
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| Co-Investigator(Kenkyū-buntansha) |
KINO Kuniki 早稲田大学, 理工学術院, 教授 (60318764)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 微生物 / 酵素 / NRPS / ポリアミノ酸 / 生体機能利用 / 生物活性物質 / バイオ生産プロセス / 二次代謝物 / 物質生産 / 微生物機能 / 二次代謝産物 / 生体触媒工学 / 生物機能工学 / 生体高分子 |
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| Research Abstract |
Recently, peptides are expected as materials of functional foods or medicine. In this research, we aim to analyze the poly-amino acid synthesizing enzymes and their synthesizing mechanisms, isolation and characterization of various new poly-amino acid producing microorganisms were performed. And then a gene encoding poly-amino acid synthesizing enzyme was characterized. Through the screening with a charged dye and MALDI-TOF MS analysis, various new poly-amino acid producing microorganisms containing a new basic poly-amino acid producing microorganism were obtained. Moreover, a gene encoding NPRS-like enzyme was analyzed.
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