| Project/Area Number |
22603017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
ケミカルバイオロジー
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
TSUDA Leo 独立行政法人国立長寿医療研究センター, 創薬モデル動物開発研究PT, プロジェクトリーダー (30333355)
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| Co-Investigator(Kenkyū-buntansha) |
LIM Young-mi 国立長寿医療研究センター, 創薬モデル動物開発研究PT, 研究員 (60421898)
山崎 泰豊 独立行政法人国立長寿医療研究センター, 創薬モデル動物開発研究室, 研究員 (90435876)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 難聴 / ショウジョウバエ / 感覚器 / ケミカルバイオロジー / ストレス応答 / 転写抑制 / 加齢 / 加齢性感覚器障害 / 加齢性難聴 / 神経変性 / 転写コリプレッサー / マウス / ポリフェノール / アポトーシス / テトラヒドロクルクミン / Ebi / TBL1 / 寿命制御 / 酸化ストレス応答 / FOXO / 感覚細胞 / 加齢性疾患 |
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| Research Abstract |
The survival of sensory neurons is essential for the long-term maintenance of sensory function, and defects in sensory cells survival lead to the onset of age-related sensory defects such as hearing loss or retinitis pigmentosa. In this study we have shown that there seems to be a mechanism, which represses the expression of apoptotic genes, under stress signalling of Drosophila sensory organs. We expect that the mechanism for maintaining photoreceptor cells will lead to the comprehensive understanding of sensory defects, such as age-related hearing disorders.
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