| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Mg-promoted reductive coupling of aromatic carbonyl compounds and ethyl trifluoroacetate brought about selective formation of fluorine-containing organic compounds. In general, the synthesis of fluorinated compounds is not easy, but it could be achieved by use of cheaper fluorine-containing reagents in these reactions. The reductive coupling reaction of aromatic carbonyl compounds and carbon dioxide gave the carboxylated compounds through the carbon-carbon bond formation. Mg-promoted reductive trifluoroacetylation of azulene led to the synthesis of 6-trifluoroacetylazulene in good yield.
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